Scienture Provides Annual Shareholder Update, Outlining Significant Progress and Strategic Priorities for the Year Ahead
COMMACK, NY, April 06, 2026 (GLOBE NEWSWIRE) -- SCIENTURE HOLDINGS, INC. (NASDAQ: SCNX) (“Scienture”) a holding company for existing and planned pharmaceutical operating companies focused on providing enhanced value to patients, physicians and caregivers through developing, bringing to market, and distributing novel specialty products to satisfy unmet market needs, today provided an annual update from its Co-Chief Executive Officers, Narasimhan Mani and Shankar Hariharan, to its shareholders:
To Our Valued Shareholders,
This past year marked a pivotal period for Scienture, as we advanced our strategy to build a differentiated, branded specialty pharmaceutical platform. We are pleased to share this annual update and highlight the progress we have made in executing our mission to deliver innovative therapies that improve patient outcomes while creating long-term shareholder value.
Scienture is focused on the commercialization and development of branded pharmaceutical products that address unmet needs through improved disease management, convenience, and patient access. Our portfolio currently includes two FDA-approved products and three pipeline candidates targeting large and growing markets, including migraine, thrombosis, and post-operative pain.
2025 Operational Highlights
During the year, we achieved several key milestones that position the company for continued growth:
- Completed the strategic acquisition of REZENOPY™ in March 2025
- Received FDA approval for Arbli™, our first internally developed product, in March 2025
- Successfully commercially launched Arbli™ in September 2025
Arbli™, the first and only FDA-approved liquid formulation of losartan for hypertension, has been successfully introduced to the market, positioning us to drive revenue growth into 2026 and beyond.
Looking ahead, we expect to launch REZENOPY™ in the second quarter of 2026. As the highest-dose FDA-approved naloxone nasal spray for emergency treatment of opioid overdose, REZENOPY™ is expected to expand our commercial portfolio and strengthen our revenue base.
We have built a scalable and established commercial infrastructure designed to support current and future product launches.
Commercial Execution and Market Traction
We are seeing encouraging early traction from the Arbli™ launch in the approximately $241 million U.S. losartan market, which represents approximately 72 million annual prescriptions (IQVIA MAT December 2025). Our commercial strategy is focused on targeted engagement with high-value healthcare professionals who account for approximately 80% of prescription volume.
Key commercial capabilities for Arbli™ include:
- Sales & Marketing: Field, virtual, and digital capabilities, with anticipated sales force expansion from 9 to 16 representatives in the second quarter of 2026
- Channel Access: Broad reach across retail, institutional, government, and direct-to-consumer channels
- Market Access: Established commercial insurance coverage and placement within major national formularies
- Distribution: Nationwide availability through full-line wholesalers
- Patient Support: Comprehensive hub services, co-pay assistance, and access programs
In preparation for the REZENOPY™ launch, we have recently secured group purchasing organization (GPO) agreements, providing access to more than 5,000 healthcare facilities and approximately 60% of the U.S. institutional market. With a U.S. naloxone market of approximately $141 million and 9.4 million annual prescription units (IQVIA MAT January 2026), we believe REZENOPY™ is well positioned to drive adoption and capture market share.
R&D Pipeline and Long-Term Growth Strategy
We are building a differentiated, capital-efficient R&D platform designed to support sustained long-term growth and value creation. Our strategy focuses on leveraging established regulatory pathways, targeting large addressable markets, and advancing product candidates with meaningful clinical and commercial potential. This approach is reflected in the following key initiatives:
- Leveraging efficient 505(b)(2) NDA and BLA regulatory pathways
- Partnering with leading organizations across development, manufacturing, and clinical operations
- SCN-102 (Migraine): NDA filing expected in the second half of 2027
- SCN-106 (Thrombosis): BLA filing expected in the second half of 2028
- Continued expansion of our intellectual property portfolio
In parallel, we are actively evaluating strategic acquisition opportunities to further expand our portfolio and enhance long-term growth.
2025 Financial Summary and Highlights Compared to 2024:
- Net revenue increased 216% year-over-year to $431,609 from $136,643, driven by the commercial launch of Arbli™
- Gross Margin expanded over the previous year by 7,240 Basis Points to 76.8%
- Research and Development expenses decreased 13% year-over-year to $2.0 million
- As of December 31, 2025, the company had cash and cash equivalents of approximately $6.7 million and positive working capital of approximately $5.2 million
Net loss from continuing operations, net of tax, was approximately $41.5 million for the year ended December 31, 2025, compared to approximately $18.2 million in 2024. The increase was primarily driven by a one-time, non-cash impairment charge of $26.3 million recorded in 2025, with no comparable charge in the prior year. In addition, for the year ended December 31, 2024, income from discontinued operations, net of tax, was approximately $27.3 million, primarily from the gain on the sale of certain assets and the disposition of a former subsidiary in the first half of 2024.
Excluding the one-time, non-cash impairment charge, net loss from continuing operations, net of tax, improved to approximately $15.2 million, reflecting underlying operational progress. Adjusted EBITDA was approximately $(5.4) million in 2025, compared to approximately $17.8 million in 2024. This change reflects the company’s transition from a diversified operating model in 2024 to a focused specialty pharmaceutical business in 2025, with initial Arbli™ revenues commencing in the third quarter and increased investment in commercial infrastructure.
Importantly, we maintained a disciplined approach to capital management throughout the year. We fully repaid legacy debt obligations, funded our working capital needs, and strengthened our balance sheet. As of year-end, the company had approximately $6.7 million in cash and positive working capital of approximately $5.2 million, providing an estimated 12-month runway to support ongoing operations and growth initiatives while preserving financial flexibility.
Nasdaq Compliance
As previously disclosed, the company has until April 13, 2026 to regain compliance with Nasdaq’s minimum bid price requirement. If we do not regain compliance during this initial compliance period, we may be eligible for an additional 180-calendar day compliance period, subject to maintaining compliance with all other applicable Nasdaq Capital Market listing standards. We believe we are well positioned to meet the requirements for this additional compliance period and intend to request the extension, if necessary. The Company remains focused on executing initiatives to support compliance; however, any such extension is subject to Nasdaq’s review and approval, and there can be no assurance that it will be granted.
2026 Outlook
We entered 2026 with a strong commercial platform, a focused product strategy, a solid scientific foundation, and an experienced leadership team. With key building blocks now in place, we believe Scienture is well positioned to drive continued innovation, improve patient outcomes, and deliver long-term shareholder value.
Over the next 12 months, we will focus on:
- Maximizing commercial performance by expanding market penetration of our existing products and broadening our portfolio
- Advancing our pipeline efficiently to achieve key clinical and regulatory milestones and bring new therapies to market
- Scaling our infrastructure to support sustainable, long-term growth
- Investing in our sales team, further strengthening our organization to drive execution and performance
Conclusion
Over the past year, we have made meaningful progress across both our commercial portfolio and research and development pipeline. Our commercial products have been well received by customers and stakeholders, and we are executing a clear strategy to drive adoption, expand market presence, and deepen engagement with healthcare providers and patients.
At the same time, we have continued to invest in our R&D engine, advancing a thoughtfully constructed pipeline across multiple therapeutic areas. Based on our analysis of market dynamics, patient needs, and the broader healthcare landscape, we believe our pipeline has the potential to address significant unmet medical needs while expanding our long-term revenue opportunities.
We remain committed to the highest standards of execution, transparency, and governance, and we appreciate your continued support as we advance our mission to deliver innovative therapies and drive long-term shareholder value.
Sincerely,Co-Chief Executive OfficersNarasimhan Mani and Shankar Hariharan
Non-GAAP Financial Measures
In addition to our financial results determined in accordance with the generally accepted accounting principles in the United States (“GAAP”), our management uses earnings before interest, taxes, depreciation, and amortization expenses to net income (“EBITDA”), a non-GAAP measure, as a key measure in operating our business. We use adjusted EBITDA as a measure of our operating performance. Management believes that the non-GAAP measures used in this press release provide investors with important perspectives on the company’s ongoing business and financial performance and are helpful to provide investors with an understanding of our core operating results.
The non-GAAP financial measures disclosed by the company should not be considered a substitute for, or superior to, financial measures calculated in accordance with GAAP. Neither EBITDA nor adjusted EBITDA represents net income (loss) or cash flows provided by operating activities as determined in accordance with GAAP and should not be considered as alternative measures of profitability or liquidity. Our use of non-GAAP financial measures has certain limitations in that the non-GAAP financial measures we use may not be directly comparable to those reported by other companies due to potential differences in methods of calculation and items being excluded. A reconciliation is provided below for adjusted EBITDA to the most directly comparable financial measure presented in accordance with GAAP. Investors are encouraged to review the related GAAP financial measure and the reconciliation of adjusted EBITDA to its most directly comparable GAAP financial measure.
For the year ended December 31, 2025, adjusted EBITDA was $(5,384,274), compared to adjusted EBITDA of $17,820,898 for the year ended December 31, 2024. The decrease reflects the transition from a diversified operating business (which included asset-sale activities in 2024) to a focused specialty pharmaceutical company in 2025, with initial Arbli™ revenues commencing in the third quarter of 2025 and higher operating costs associated with the build-out of commercialization infrastructure. Excluding the non-cash impairment charges of $26,346,050 recognized in 2025, adjusted EBITDA was $(5,384,274), reflecting the early-stage commercial nature of the business. The following table reconciles net loss from continuing operations to adjusted EBITDA for the years ended December 31, 2025 and 2024.
| Year Ended | ||||||||
| December 31, | ||||||||
| 2025 | 2024 | |||||||
| Net (loss) income | $ | (41,512,264 | ) | $ | 9,065,798 | |||
| Depreciation and amortization | 491,781 | 53,361 | ||||||
| Benefit for income taxes | 1,994,878 | |||||||
| Interest expense | 4,083,206 | 1,335,631 | ||||||
| Other non-operating expenses (income) | (3,166,906 | ) | 2,742,230 | |||||
| Stock based compensation (non-cash) | 6,378,981 | 4,623,878 | ||||||
| Impairment loss | 26,346,050 | - | ||||||
| Adjusted EBITDA | $ | (5,384,274 | ) | $ | 17,820,898 | |||
About Arbli™
Arbli™ is a novel proprietary formulation of losartan, a widely prescribed angiotensin receptor blocker (ARB) for hypertension. It is the first and only liquid formulation of losartan on the market that does not require compounding and has reduced dosing volume and long-term shelf life at room temperature storage. Arbli™ is FDA-approved for the treatment of hypertension in patients greater than six years old, for reducing the risk of stroke in patients with hypertension and left ventricular hypertrophy, and for treating diabetic nephropathy in certain patients with type 2 diabetes. By offering a safe, effective, and convenient liquid alternative, Arbli™ provides a tailored solution for patients who require or prefer a liquid formulation. As an FDA-approved product, Arbli™ provides consistent quality and dosing accuracy, addressing the risks and inconsistencies often associated with extemporaneously compounded losartan prescriptions. Arbli™ has two issued patents from the USPTO, which are also listed in the FDA Orangebook.
Arbli™ is the first and only oral liquid formulation of losartan approved by the U.S. FDA. Arbli™ comes in a 165 mL bottle as a peppermint flavored suspension that does not require refrigeration and has been approved for a shelf life of 24 months from the date of manufacture when stored at room temperature.
INDICATION
Arbli™ is an angiotensin II receptor blocker (ARB) indicated for:
- Treatment of hypertension, to lower blood pressure in adults and children greater than 6 years old. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions.
- Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy.
- Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria in patients with type 2 diabetes and a history of hypertension.
IMPORTANT SAFETY INFORMATION
- Do not take Arbli™ when pregnant. When pregnancy is detected, discontinue Arbli™ as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. Arbli™ can cause fetal harm when administered to a pregnant woman. Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death.
- Do not co-administer Arbli™ with aliskiren in patients with diabetes. Avoid use of aliskiren with Arbli™ in patients with renal impairment (GFR
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