Histogen Publishes Preclinical Data on its HST 004 Spinal Disc Program
SAN DIEGO, May 14, 2020 (GLOBE NEWSWIRE) -- Histogen Inc., a regenerative medicine company with a novel biological platform that replaces and regenerates tissues in the body, announced today the publication of data on HST 004, its patented, naturally-derived material for spinal disc repair in the Journal of Medicine and Surgical Sciences.
Histogen has developed a cell conditioned media (CCM) that is embryonic-like in composition and that has been shown to stimulate stem cells in vivo. The material expresses stem cell-associated proteins, including nodal, brachyury, nestin and Oct4, and has the potential to reduce inflammation and stimulate autologous intravertebral disc (IVD) cells, which can lead to the repair of IVD matrix.
In a spinal disc study, HST 004 reversed inflammation and protease activity and stimulated aggrecan secretion in the thrombin-induced rabbit ex vivo model. In vivo studies in the rabbit degenerative disc model showed that, in as little as 4 weeks post treatment with HST 004, disc height increased as compared to the control. MRI analysis demonstrated regeneration of the disc tissue (Pfirrmann grading analysis p
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