Fintel reports that on November 20, 2025, Leerink Partners upgraded their outlook for Agios Pharmaceuticals (NasdaqGS:AGIO) from Market Perform to Outperform.
Analyst Price Forecast Suggests 125.55% Upside
As of November 17, 2025, the average one-year price target for Agios Pharmaceuticals is $50.39/share. The forecasts range from a low of $40.40 to a high of $59.85. The average price target represents an increase of 125.55% from its latest reported closing price of $22.34 / share.
See our leaderboard of companies with the largest price target upside.
The projected annual revenue for Agios Pharmaceuticals is 137MM, an increase of 206.18%. The projected annual non-GAAP EPS is -6.53.
What is the Fund Sentiment?
There are 482 funds or institutions reporting positions in Agios Pharmaceuticals. This is an increase of 15 owner(s) or 3.21% in the last quarter. Average portfolio weight of all funds dedicated to AGIO is 0.15%, an increase of 12.43%. Total shares owned by institutions increased in the last three months by 2.05% to 70,748K shares. 
The put/call ratio of AGIO is 0.69, indicating a bullish outlook.
What are Other Shareholders Doing?
Farallon Capital Management holds 5,781K shares representing 9.91% ownership of the company. In its prior filing, the firm reported owning 5,767K shares , representing an increase of 0.24%. The firm increased its portfolio allocation in AGIO by 14.78% over the last quarter.
Bellevue Group holds 3,715K shares representing 6.37% ownership of the company. In its prior filing, the firm reported owning 3,590K shares , representing an increase of 3.35%. The firm decreased its portfolio allocation in AGIO by 2.56% over the last quarter.
Erste Asset Management holds 2,765K shares representing 4.74% ownership of the company. In its prior filing, the firm reported owning 2,326K shares , representing an increase of 15.86%. The firm increased its portfolio allocation in AGIO by 61.12% over the last quarter.
Paradigm Biocapital Advisors holds 2,674K shares representing 4.58% ownership of the company. In its prior filing, the firm reported owning 1,143K shares , representing an increase of 57.27%. The firm increased its portfolio allocation in AGIO by 88.11% over the last quarter.
Wellington Management Group Llp holds 2,471K shares representing 4.24% ownership of the company. In its prior filing, the firm reported owning 422K shares , representing an increase of 82.92%. The firm decreased its portfolio allocation in AGIO by 3.56% over the last quarter.
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