Primmune Therapeutics is a clinical‑stage biotechnology company based in San Diego, California, focused on developing systemic cancer immunotherapies that activate the immune system in a precise and controlled way. In this episode, Charles (Charlie) McDermott, CEO & Director of Primmune Therapeutics, discusses the company’s mission to strengthen antitumor immunity, enhance the effectiveness of existing cancer treatments, and improve long‑term disease control by engaging both the innate and adaptive immune systems. Primmune’s approach is designed to generate durable immune responses against cancer - going beyond T‑cell activation alone. The company’s lead investigational program, PRTX007, is an orally administered small‑molecule TLR7 agonist engineered to drive coordinated immune activation. At the heart of Primmune’s work is the vision to bring powerful immunotherapies earlier in care and expand the opportunity to cure cancer for more patients worldwide.

In this episode of The Signal, Dr. Varun Sivaram, CEO and Founder of Emerald AI, discusses how the company is transforming AI data centers from burdens on the power grid into strategic assets. He shares Emerald AI’s long‑term vision to strengthen America’s leadership in the global AI race by unlocking the power needed for innovation, while keeping energy sustainable and affordable.

AI is changing how customers discover and trust brands, and Profound is building the marketing infrastructure for that future. In this interview, Co‑Founder & CEO James Cadwallader shares why every company will soon care deeply about how AI talks about their brand, and why agents will become the operational layer of modern marketing. Profound already supports 10% of the Fortune 500 and major agencies with tools to monitor how brands appear across answer engines and take action to shape that narrative. With Profound Agents, the platform is moving beyond measurement into orchestration and automation, helping teams close the gap between strategy and execution.

Xanadu is building secure connections across every device, workload, and machine - laying the foundation for the quantum-powered future. According to Founder and CEO Christian Weedbrook, quantum computing is rapidly transforming the world, with breakthroughs emerging across industries such as pharmaceuticals, materials design, quantum chemistry, artificial intelligence, finance, and beyond. As these technologies evolve, Xanadu is at the forefront, enabling the secure, scalable infrastructure needed to unlock their full potential.

From florals to chocolates, for Valentine’s Day, Mother’s Day, and every occasion in between, UrbanStems is redefining the premium gifting experience. With a rotating selection of thoughtfully designed seasonal bouquets and curated gifts, the brand connects with customers in meaningful ways, meeting them wherever they are. In this video, UrbanStems CEO Meenakshi Lala shares insight into the company’s current strategy and the opportunities driving its continued growth in an evolving market.

Midi Health is addressing a long‑standing gap in healthcare by delivering specialized care for women nationwide. The platform supports women across a broad range of health needs, providing care for thousands of patients and helping them feel better, stay resilient, and perform at their best – at work, at home, and everywhere in between. In this interview, Joanna Strober, Co-Founder & CEO of Midi Health, shares how the company is expanding access to specialized women’s healthcare across the country – and why she believes the future of care is virtual.

From transforming workflows to creating next‑generation AI agents, Torq is redefining modern security operations — making them faster, more scalable, and more intelligent. In this episode, Torq CEO Ofer Smadari dives into how Torq drives AI‑powered automation across the SOC and what’s coming next.