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SPHERA FUNDS MANAGEMENT LTD. Information

21 HA'ARBA'AH STREET, TEL AVIV, , 64739, (723) 684-5535

Report Date: 03/31/2019

Position Statistics

Total Positions 126
New Positions 29
Increased Positions 55
Decreased Positions 57
Positions with Activity 112
Sold Out Positions 31
Total Mkt Value (in $ millions) 689

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Energy 1.11%
Basic Materials
Industrials 1.13%
Consumer Cyclicals 2.98%
Consumer Non-Cyclicals
Financials 1.47%
Healthcare 83.31%
Technology 8.98%
Telecommunication Services 1.01%
Utilities

126 Positions as of 03/31/2019

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BRISTOL MYERS SQUIBB CO COM 41,734 11,853 39.67 879,900
JOHNSON & JOHNSON COM 36,602 36,602 New 265,000
GILEAD SCIENCES INC COM 31,930 8,648 37.14 480,000
ALEXION PHARMACEUTICALS INC COM 31,852 10,201 47.12 247,300
AMICUS THERAPEUTICS INC COM 30,628 493 1.64 2,488,078
MERCK & CO INC COM 29,972 -7,553 (20.13) 377,000
ASTRAZENECA PLC SPONSORED ADR 26,516 7,008 35.92 700,000
CELGENE CORP COM 24,063 -20,694 (46.24) 250,000
MYLAN N V SHS EURO 19,715 -13,276 (40.24) 1,002,307
NOVO-NORDISK A S ADR 19,012 19,012 New 400,000
GLAXOSMITHKLINE PLC SPONSORED ADR 16,938 4,727 38.71 430,000
VERINT SYS INC COM 16,187 7,042 77.01 263,926
UROGEN PHARMA LTD COM 12,135 12,135 New 308,377
BLUEBIRD BIO INC COM 10,496 -6,889 (39.63) 83,796
ARQULE INC COM 10,272 -4,302 (29.52) 1,432,643
SAREPTA THERAPEUTICS INC COM 8,896 -5,225 (37) 73,405
PTC THERAPEUTICS INC COM 8,833 -5,008 (36.18) 220,500
INTERCEPT PHARMACEUTICALS INC COM 8,775 8,775 New 100,000
ASCENDIS PHARMA A S SPONSORED ADR 8,627 1,264 17.16 68,273
CELLECTIS S A SPONSORED ADS 8,305 New 447,970