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BAKER BROS. ADVISORS LP Information

860 WASHINGTON STREET, NEW YORK, New York, 10014, (212) 339-5600

Report Date: 03/31/2019

Position Statistics

Total Positions 97
New Positions 7
Increased Positions 23
Decreased Positions 10
Positions with Activity 33
Sold Out Positions 4
Total Mkt Value (in $ millions) 14,499

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Energy
Basic Materials
Industrials
Consumer Cyclicals
Consumer Non-Cyclicals
Financials
Healthcare 100%
Technology
Telecommunication Services
Utilities

97 Positions as of 03/31/2019

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SEATTLE GENETICS INC COM 3,529,580 256 .01 51,049,760
INCYTE CORP COM 2,801,722 1,653 .06 34,271,827
BEIGENE LTD SPONSORED ADR 1,514,233 New 11,959,824
ALEXION PHARMACEUTICALS INC COM 1,088,158 276 .03 8,558,068
ACADIA PHARMACEUTICALS COM 1,030,971 New 39,713,842
AMARIN CORP PLC SPONS ADR NEW 761,800 10,889 1.45 43,210,459
BIOMARIN PHARMACEUTICAL INC COM 675,978 New 7,589,294
GENOMIC HEALTH INC COM 551,457 -83,542 (13.16) 10,198,943
ASCENDIS PHARMA A S SPONSORED ADR 437,209 71,304 19.49 3,390,270
MIRATI THERAPEUTICS INC COM 192,883 New 2,513,462
ARGENX SE SPONSORED ADR 140,067 New 1,019,557
MADRIGAL PHARMACEUTICALS INC COM 115,010 New 1,169,278
ARRAY BIOPHARMA INC COM 104,088 -32,492 (23.79) 3,842,289
HERON THERAPEUTICS INC COM 91,229 New 5,018,104
NEUROCRINE BIOSCIENCES INC COM 87,773 29,425 50.43 1,098,670
KODIAK SCIENCES INC COM 87,153 New 9,145,115
SPARK THERAPEUTICS INC COM 82,960 -69,751 (45.68) 751,927
GW PHARMACEUTICALS PLC ADS 78,653 New 428,345
CYMABAY THERAPEUTICS INC COM 73,626 10,187 16.06 5,707,411
RHYTHM PHARMACEUTICALS INC COM 70,413 New 2,708,200