Why Agenus' Stock Tumbled in August

IBB Chart

What : Agenus , a small immunology company developing treatments for cancer and a diversity of infectious diseases, saw its shares drop by double digits last month, even outpacing the broader biotech industry's marked decline in August:

IBB data by YCharts .

The good news is that this "leg down" wasn't triggered by a specific catalyst. Rather, it appears to be linked to the stock's incredible performance prior to the August blood bath that hit small-cap biotechs particularly hard. Specifically, Agenus' stock was up a whopping 114% heading into August:

IBB data by YCharts .

So what : Agenus' huge upward swing this year has mainly been the result of the company's expanding clinical activities in the red-hot area of immuno-oncology, fueled by its purchase of 4-Antibody last year and subsequently gaining the rights toantibodies targeting Carcinoembryonic Antigen Cell Adhesion Molecule 1 (CEACAM1) from Diatheva s.r.l. this year.

In other words, it wasn't the result of a specific clinical or regulatory catalyst, meaning that this rapid price appreciation is, at least partly, due to hype. That's not to say that this hype over immunoncology drugs, in general, and checkpoint inhibitors, in particular, isn't justified -- at least to some degree. But the market acted like a proverbial "man with a hammer" toward all of these types of stocks that soared earlier in the year based on their potential, not fundamentals.

Now what : Agenus' future as a player in the emerging realm of immuno-oncology is basically impossible to tell at this point because of the early-stage nature of its clinical efforts. On the bright side, it's developing several checkpoint inhibitors, and has signed research deals with major pharmas like Incyte Corp. and Merck , to help cover some of the costs.

Agenus also recently shored up its balance sheet in a big way via a$115 million non-dilutive financing deal withOberland Capital. After closing this transaction, the company should now have around $200 million in cash and cash equivalents remaining, giving it an ample cash runway to develop these promising immuno-oncology assets.

While a fair value assessment of the company's clinical pipeline is tantamount to a guessing game at this point, I'm cautiously optimistic that Agenus does have enough irons in the fire to develop at least one single major oncology product within the next two or three years. Its improving financial situation should also keep dilution to a minimum until then.

Investors with a healthy appetite for volatility, and its bedfellow risk, may want to take a deeper look at this high-risk, potential high-reward biotech.

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The article Why Agenus' Stock Tumbled in August originally appeared on

George Budwell has no position in any stocks mentioned. The Motley Fool has no position in any of the stocks mentioned. Try any of our Foolish newsletter services free for 30 days . We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy .

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