Markets
MRK

Why Advaxis Inc. Shares Soared Today

Although we don't believe intiming the market or panicking over market movements, we do like to keep an eye on big changes -- just in case they're material to our investing thesis.

What: Shares in Advaxis Inc . jumped by 17% today after the company announced that patient enrollment is under way for an early stage trial that will study its ADXS-PSA immunotherapy alongside Merck & Co 's Keytruda as a treatment for prostate cancer.

So What : The study will enroll 51 previously-treated patients who are diagnosed with metastatic castration-resistant prostate cancer.

The trial will include an arm in which patients will receive ADXS-PSA as a monotherapy and another arm in which patients will receive the two drug combination. The early stage trial's primary endpoint is safety and tolerability, which is typical for early stage studies. However, secondary endpoints for anti-tumor activity and progression free survival could also provide insight into whether this therapy could improve patient outcomes.

Now What: ADXS-PSA is an immunotherapy that is designed to stimulate an immune system response to PSA. In preclinical trials, combining ADXS-PSA with Keytruda showed signs of anti-tumor activity, but pre-clinical research often doesn't translate into successful human trials. Historically, more than 90% of drugs entering human trials fail to make it to commercialization.

That suggests that the odds are stacked against Advaxis and that investors ought to approach it with a healthy dose of caution. Since it will be a while before we know the outcome of this study, investors may want to be patient and wait to see the trial results from this study, or the results from Advaxis' phase 2/3 trial of ADXS-HPV as a treatment for anal cancer, before chasing this stock higher.

This $19 trillion industry could destroy the Internet

One bleeding-edge technology is about to put the World Wide Web to bed. And if you act right away, it could make you wildly rich. Experts are calling it the single largest business opportunity in the history of capitalism... The Economist is calling it "transformative"... But you'll probably just call it "how I made my millions." Don't be too late to the party -- click here for one stock to own when the Web goes dark.

The article Why Advaxis Inc. Shares Soared Today originally appeared on Fool.com.

Todd Campbell has no position in any stocks mentioned. Todd owns E.B. Capital Markets, LLC. E.B. Capital's clients may or may not have positions in the companies mentioned. The Motley Fool has no position in any of the stocks mentioned. Try any of our Foolish newsletter services free for 30 days . We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy .

Copyright © 1995 - 2015 The Motley Fool, LLC. All rights reserved. The Motley Fool has a disclosure policy .

The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.


The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

In This Story

MRK ADXS

Other Topics

Stocks

Latest Markets Videos

    The Motley Fool

    Founded in 1993 in Alexandria, VA., by brothers David and Tom Gardner, The Motley Fool is a multimedia financial-services company dedicated to building the world's greatest investment community. Reaching millions of people each month through its website, books, newspaper column, radio show, television appearances, and subscription newsletter services, The Motley Fool champions shareholder values and advocates tirelessly for the individual investor. The company's name was taken from Shakespeare, whose wise fools both instructed and amused, and could speak the truth to the king -- without getting their heads lopped off.

    Learn More