Top Biotech Stocks to Buy in 2016

IBB Chart
IBB Chart

Biotech stocks have been a great place to have money invested for several years now , so in that spirit, we reached out to our team of Motley Fool contributors and asked them to share their top biotechnology stock idea for 2016. Read below to see what biotech stocks we think are primed to outperform in the year ahead.

Selena Maranjian:Biogen Inc is a stock I'd strongly consider buying in 2016 -- if I hadn't already snapped up some shares some months back. Its stock has fallen by more than 15% over the past year as management reorganizes (and downsizes, shedding about 11% of the workforce), and this to me presents a buying opportunity .

Biogen leads the market in multiple sclerosis (MS) drugs and has a blockbuster with its MS drug Tecfidera. Its pipeline features a handful of drugs in late-stage development, such as ones targeting Alzheimer's disease, spinal muscular atrophy, diffuse large B-cell lymphoma, indolent non-Hodgkin's lymphoma, and many more in earlier development stages. There's blockbuster potential in its pipeline, too -- with many having high hopes for its Alzheimer's candidate -- though candidates still have to do well in final trials, earn FDA approval, and then sell well. Biogen is aiming to boost Tecfidera sales (a slow-down was part of the reason the stock has declined lately) through direct-to-consumer marketing, such as via TV commercials.

Some wonder whether Biogen might begin paying a dividend in the near future. Investors shouldn't count on that, but in the meantime, Biogen has been repurchasing plenty of shares, which is another way to reward existing shareholders. Share count has fallen from about 345 million in 2006 to 235 million recently.

Revenue has roughly doubled over the past four years, while net margins have grown, recently near 35%. For those seeking biotech exposure in their portfolios, Biogen is worth consideration, as it's a large and proven company, with multiple drugs on the market and selling well, and many additional promising drugs in its pipeline.

Brian Feroldi : While 2015 was a decent year to have money in biotech stocks in general, investors in Medivation , a profitable biotechnology company focused on treating cancer, were left behind. Medivation's stock shed nearly 20% of its value during the year, and it is currently trading at a trailing price-to-earnings ratio of only 28. I think is simply too cheap for a company that continues to show fast growth , so I feel quite bullish about this company's prospects heading into 2016.

Shares are up more than 1,170% over the past five years thanks to the huge success of Xtandi, Medivation's metastatic castration-resistant prostate cancer drug. Xtandi continues to show stellar growth numbers, which allowed Medivation as a whole to put up total revenue growth of 30% in the most recent quarter. The odds look good that Xtandi will be able to continuing growing for years into the future as it is currently in late-stage clinical trials for treating breast cancer.

Medivation also has a second cancer drug in late-stage trials called talazoparib. This PARP inhibitor showed promise in trials as a potential treatment for breast cancer. Medivation is planning on providing investors with updated clinical results for talazoparib sometime in the middle of 2016. If those updates look good, then talazoparib could be submitted for approval soon after, which may be a great catalyst that helps get Medivation's stock moving in the right direction again.

Given its fast growth rates, exciting late-stage pipeline, and bargain stock price, I think Medivation is a great deal right now.

Sean Williams: For those of you looking for a higher-risk, higher-reward play, I'd consider Lexicon Pharmaceuticals as a top biotech stock for 2016.

The way I see it, Lexicon Pharmaceuticals has three major catalysts working in its favor. First, Lexicon met its primary endpoint in both the TELESTAR and TELECAST phase 3 trials involving telotristat etiprate, a treatment for carcinoid syndrome in cancer patients with metastatic neuroendocrine tumors. In TELECAST, telotristat etiprate in both the 250 mg and 500 mg doses led to a statistically significant reduction in urinary 5-HIAA levels, whereas in the TELESTAR trial, both doses led to a statistically significant reduction in bowel movements. Both trials evaluated patients over a 12-week period. Success in both late-stage studies sets Lexicon up for potentially its first approval of a commercial product in 2016.

Secondly, Lexicon is riding high after securing a collaborative deal with Sanofi in November for SGLT1 and SLGT2 inhibitor sotagliflozin. Under the terms of the deal, Lexicon is to receive $300 million upfront, and it may qualify for $1.4 billion in development, regulatory, and sales milestones. Sanofi has agreed to handle the clinical development of the drug for type 2 diabetes, with Lexicon handling development for type 1 diabetes. This deal removed any near-term cash concerns for Lexicon and should allow it and its shareholders to focus solely on clinical progress (and a potential telotristat etiprate launch) in 2016.

Finally, Lexicon is expected to report phase 3 data for two of its three ongoing type 1 diabetes studies for sotagliflozin by roughly September 2016 (according to These 24-week trials assess the change in A1C levels from baseline, and a separate study examines the change in baseline A1C versus a placebo. The third study, expected in Q1 2017, is examining what proportion of trial patients have A1C levels below 7% at the 24-week mark, and it has secondary efficacy endpoints that include body weight and systolic blood pressure changes from baseline. Because SGLT2 inhibitors have demonstrated weight loss and improved glycemic control in trials, the hope is that a double-dose of SGLT1 (which works in the gastrointestinal tract) and SGLT2 (which works in the kidneys) could be the most effective diabetes therapy to hit the market.

Long story short, I'm excited for Lexicon in 2016.

The next billion-dollar iSecret

The world's biggest tech company forgot to show you something at its recent event, but a few Wall Street analysts and the Fool didn't miss a beat: There's a small company that's powering their brand-new gadgets and the coming revolution in technology. And we think its stock price has nearly unlimited room to run for early, in-the-know investors! To be one of them, just click here .

The article Top Biotech Stocks to Buy in 2016 originally appeared on

Brian Feroldi has no position in any stocks mentioned. Sean Williams has no position in any stocks mentioned. Selena Maranjian owns shares of Biogen and Medivation. The Motley Fool recommends Biogen. Try any of our Foolish newsletter services free for 30 days . We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy .

Copyright © 1995 - 2015 The Motley Fool, LLC. All rights reserved. The Motley Fool has a disclosure policy .

The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

In This Story


Other Topics


Latest Markets Videos

    The Motley Fool

    Founded in 1993 in Alexandria, VA., by brothers David and Tom Gardner, The Motley Fool is a multimedia financial-services company dedicated to building the world's greatest investment community. Reaching millions of people each month through its website, books, newspaper column, radio show, television appearances, and subscription newsletter services, The Motley Fool champions shareholder values and advocates tirelessly for the individual investor. The company's name was taken from Shakespeare, whose wise fools both instructed and amused, and could speak the truth to the king -- without getting their heads lopped off.

    Learn More