Investors were hoping that when an abstract for presentation at the upcoming American Society of Clinical Oncology was released today, it would show robust efficacy for JTX-2011, Jounce Therapeutics ' (NASDAQ: JNCE) lead drug candidate. Unfortunately, the data underwhelmed investors, sparking a steep sell-off that wiped out 35.2% of the company's market value on Thursday.
In collaboration with Celgene Corp. (NASDAQ: CELG) , Jounce has JTX-2011 in phase 2 studies as a monotherapy and in combination with Opdivo for the treatment of various solid tumor cancers, including head and neck squamous cell cancer, non-small cell lung cancer, triple negative breast cancer, melanoma, and gastric cancer.
In March, Jounce Therapeutics revealed it had submitted some trial data, including one efficacy assessment, for presentation at ASCO; today, those results were unveiled.
Specifically, as of Jan. 27, one out of seven gastric cancer patients had a partial response, and two out of five patients with triple negative breast cancer had stable disease after JTX-2011 monotherapy. In the combination cohort, there were two partial responses and two patients with stable disease out of 19 patients. Also, one out of 15 triple negative breast cancer patients had a partial response.
Jounce Therapeutics believes the data confirm that JTX-2011 has anti-tumor effects, but clearly, investors were less than impressed by the readout.
It remains to be seen, however, how the data will mature across the entire patient population, and that could make today's sell-off an overreaction. We'll have to wait for more data to parse before we can say for certain that the commercial opportunity for JTX-2011 is dashed. After all, patients in this trial are heavily pre-treated with few treatment options, so any response at all is welcome.
10 stocks we like better than Jounce Therapeutics, Inc.
When investing geniuses David and Tom Gardner have a stock tip, it can pay to listen. After all, the newsletter they have run for over a decade, Motley Fool Stock Advisor , has quadrupled the market.*
David and Tom just revealed what they believe are the 10 best stocks for investors to buy right now... and Jounce Therapeutics, Inc. wasn't one of them! That's right -- they think these 10 stocks are even better buys.
Click here to learn about these picks!
*Stock Advisor returns as of May 8, 2018
The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.