Markets

Galapagos (GLPG) Reports Positive Data on GLPG1837

Credit: Shutterstock photo

Galapagos NVGLPG announced positive top-line data from a phase I randomized, double-blind, placebo-controlled study on GLPG1837 for the treatment of patients with class III mutation in cystic fibrosis.

Data revealed that the candidate was safe and generally well-tolerated. A phase II study is expected to be initiated by the year end.

According to information provided by the company, approximately 30,000 patients and 80,000 patients are affected by cystic fibrosis in the U.S. and worldwide, respectively.

Galapagos expects to develop GLPG1837 in combination with other candidates in its pipeline, as a potential triple combination therapy for class II cystic fibrosis patients.

We remind investors that Galapagos has a collaboration agreement with AbbVie Inc. ABBV to discover, develop and commercialize potentiator and combination therapies for cystic fibrosis. Under the terms of the agreement, Galapagos received an upfront payment of $45 million from AbbVie. In addition, the company is eligible to receive up to $360 million as developmental, regulatory and sales milestones upon the achievement of minimum annual net sales thresholds, upon approval. The company is also entitled to receive double-digit royalties on net sales.

We note that Galapagos has two candidates under this collaboration - GLPG1837 and GLPG2222. In Dec 2014, the company announced the initiation of the first phase I study on GLPG1837, which triggered a milestone payment worth $10 million from AbbVie. A phase I study on GLPG2222 is expected to be initiated by the year end.

Meanwhile, the company continues to progress on its other candidates. Currently, the company is evaluating filgotinib in a phase II study (data expected in Dec 2015) for the treatment of patients with Crohn's disease. In addition, a phase III study on filgotinib for the treatment patients with rheumatoid arthritis (RA) is expected to be initiated by early 2016.

Another candidate in the company's pipeline, GLPG1205, is being evaluated in a phase II proof-of-concept study (data expected in the fourth quarter of 2015) for the treatment of patients with ulcerative colitis.

Galapagos carries a Zacks Rank #2 (Buy). Other favorably ranked stocks in the health care sector include Nexvet Biopharma Public Limited Company NVET and Anika Therapeutics Inc. ANIK , each sporting a Zacks Rank #1 (Strong Buy).

Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days . Click to get this free report >>

Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report

ABBVIE INC (ABBV): Free Stock Analysis Report

ANIKA THERAPEUT (ANIK): Free Stock Analysis Report

GALAPAGOS -ADR (GLPG): Free Stock Analysis Report

NEXVET BIOPHARM (NVET): Free Stock Analysis Report

To read this article on Zacks.com click here.

Zacks Investment Research

The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.


The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

In This Story

ABBVANIKGLPG

Other Topics

Stocks

Latest Markets Videos

Zacks

Zacks is the leading investment research firm focusing on stock research, analysis and recommendations. In 1978, our founder discovered the power of earnings estimate revisions to enable profitable investment decisions. Today, that discovery is still the heart of the Zacks Rank. A wealth of resources for individual investors is available at www.zacks.com.

Learn More