American depositary receipts of European companies declined as the region's markets retreated on corporate profit warnings.
Deutsche Lufthansa, an airline that doesn't have ADRs in the U.S., slumped 14% in Germany after reducing income forecasts. Steel-pipe maker Vallourec fell 11% after cutting guidance.
The World Bank also cut its forecast for global economic growth.
The Bank of New York Mellon Europe ADR Index fell 0.6% to bring its year-to-date gain to 3.7%. Decliners led advancers 74 to 30. The S&P 500 Stock Index fell 0.4%.
Amarin Corp. ( AMRN ) gained 2% to $1.53 per ADR after analysis showed positive results for its cholesterol-lowering drug.
Europe's advancers included Natuzzi Spa (NTZ) +1.6%, Criteo Sa (CRTO) +1.6% and Coca-Cola HBC Ag (CCH) +1.3%.
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