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AstraZeneca: LYNPARZA Shows Progression-free Survival Benefit In Five-year Follow-up Data

(RTTNews) - AstraZeneca (AZN.L, AZN) and Merck & Co., Inc., announced LYNPARZA showed a long-term progression-free survival benefit versus placebo as a 1st-line maintenance treatment in patients with newly diagnosed, advanced BRCA-mutated ovarian cancer who had a complete or partial response following platinum-based chemotherapy.

The companies said five-year follow-up data from the phase III SOLO-1 trial showed LYNPARZA reduced the risk of disease progression or death by 67% and improved progression-free survival to a median of 56.0 months versus 13.8 months for placebo. At five years, 48.3% of patients treated with LYNPARZA remained free from disease progression versus 20.5% on placebo. The median duration of treatment with LYNPARZA was 24.6 months versus 13.9 months with placebo. The safety profile of LYNPARZA was consistent with previous observations.

The phase III SOLO-1 trial met the primary endpoint of PFS in June 2018, which formed the basis of approvals in the US, the EU, Japan, China, and several other countries.

The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

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