Aptinyx (APTX) Surges on Promising Stress Disorder Study Data

Aptinyx Inc. APTX announced encouraging data from a phase II study evaluating its novel NMDA receptor modulator candidate, NYX-783, in patients with post-traumatic stress disorder (“PTSD”). Data showed clinically meaningful effect along with excellent tolerability, boosting its prospect as a promising therapeutic candidate for PTSD, one of the most complex and difficult-to-treat psychiatric conditions. Based on these promising data from the mid-stage study, the company plans to initiate a pivotal study in 2021.

Shares of Aptinyx surged more than 85% in after-market trading on Oct 19, following the study data readout. The company’s shares have increased 7% so far this year against the industry’s decrease of 0.2%.

The company was evaluating two doses of NYX-783 — 10mg or 50 mg — in phase II exploratory study in two, four-week sequential stages with no patients receiving more than four weeks of NYX-783 treatment. The primary endpoint of the study was to achieve improvement on the Clinician-Administered PTSD Scale, CAPS-5 total score, and symptom domain sub-scores.

Data from the study showed that treatment with either dose of NYX-783 achieved clinically meaningful and statistically significant improvement in CAPS-5 total score compared to placebo. However, the higher dose of the candidate demonstrated more consistent effects than the lower dose.

Clinically meaningful improvement was observed within just four weeks in the 50 mg dose arm. A total of 78% of patients achieved a 30% improvement from baseline in the CAPS-5 total score versus 44% of patients in the placebo arm. Moreover, 50% of patients administered a 50mg dose of NYX-783 achieved a 50% CAPS-5 total score improvement from baseline compared to 26% of patients receiving placebo.

Please note that NYX-783 enjoys Fast Track designation in the United States for treating PTSD.

We note that the complexity of the PTSD makes it difficult to treat with very few treatment options available including Glaxo’s GSK Paxil and Pfizer’s PFE Zoloft. This represents a significant opportunity for NYX-783 following a potential approval.

Apart from NYX-783, Aptinyx is also developing two other NMDA receptor-targeted candidates — NYX-2925 and NYX-458 — in mid-stage studies. NYX-2925 is being developed for treating chronic pain indications including fibromyalgia and painful diabetic peripheral neuropathy.  The company is evaluating NYX-458 as a potential treatment for Parkinson’s disease and cognitive impairment.

We remind investors that there are several companies, including J&J JNJ, Eli Lilly, and Roche developing NMDA receptor-targeted candidates, which will likely provide competition to Aptinyx’s pipeline going forward.

Aptinyx Inc. Price

Aptinyx Inc. Price

Aptinyx Inc. price | Aptinyx Inc. Quote

Zacks Rank

Aptinyx currently carries a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.

These Stocks Are Poised to Soar Past the Pandemic

The COVID-19 outbreak has shifted consumer behavior dramatically, and a handful of high-tech companies have stepped up to keep America running. Right now, investors in these companies have a shot at serious profits. For example, Zoom jumped 108.5% in less than 4 months while most other stocks were sinking.

Our research shows that 5 cutting-edge stocks could skyrocket from the exponential increase in demand for “stay at home” technologies. This could be one of the biggest buying opportunities of this decade, especially for those who get in early.

See the 5 high-tech stocks now>>

Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report
Johnson Johnson (JNJ): Free Stock Analysis Report
Pfizer Inc. (PFE): Free Stock Analysis Report
GlaxoSmithKline plc (GSK): Free Stock Analysis Report
Aptinyx Inc. (APTX): Free Stock Analysis Report
To read this article on click here.
Zacks Investment Research

The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.

Other Topics


Latest Markets Videos


    Zacks is the leading investment research firm focusing on stock research, analysis and recommendations. In 1978, our founder discovered the power of earnings estimate revisions to enable profitable investment decisions. Today, that discovery is still the heart of the Zacks Rank. A wealth of resources for individual investors is available at

    Learn More