Tony Cruz, Chief Executive Officer of Transition Therapeutics, presides over the opening bell.

Monday August 20, 2007
from Nasdaq MarketSite
in New York's Times Square

Transition Therapeutics
[TTHI]

Headquartered in Toronto, Ontario, Transition is a biopharmaceutical company, developing novel therapeutics for disease indications with large markets. Transition's lead products include AZD-103/ELND005 for the treatment of Alzheimer's disease and regenerative therapies E1-I.N.T.(tm) and GLP1-I.N.T.(tm) for the treatment of diabetes.

Transition has an emerging pipeline of preclinical drug candidates developed using its proprietary drug discovery engine. Transition's shares are listed on the Toronto Stock Exchange under the symbol "TTH". For additional information about the company, please visit www.transitiontherapeutics.com.

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Click for larger pictures of the NASDAQ MarketSite. Additional Photographs for 08/20/2007 Download Hi-Res Quality Photo of this NASDAQ Market Open - Pictured: Tony Cruz, Chief Executive Officer of Transition Therapeutics, presides over the opening bell. Organizations interested in obtaining NASDAQ-listed company bell ringing ceremony photographs for press purposes, must first receive approval from the listed company before requesting photographs from NASDAQ. Please provide the company contact information from whom you received approval to Jolene Libretto at Jolene.Libretto@nasdaq.com. Kindly credit © 2007, The Nasdaq Stock Market, Inc. Reprinted with permission. © Copyright 2007, The NASDAQ Stock Market, Inc. Reprinted with the permission of The Nasdaq Stock Market, Inc.