Donald deBethizy, Chief Executive Officer of Targacept, Inc.,
Rings The NASDAQ Stock Market Closing Bell

Friday, December 8, 2006
at NASDAQ's MarketSite
in New York City.

Targacept, Inc.
[TRGT]

Donald deBethizy, Chief Executive Officer of Targacept, Inc., presides over the closing bell.
Targacept is a clinical-stage biopharmaceutical company that discovers and develops NNR Therapeutics(tm), a new class of drugs for the treatment of central nervous system diseases and disorders. Targacept's product candidates selectively modulate neuronal nicotinic receptors that serve as key regulators of the nervous system to promote therapeutic effects and limit adverse side effects. Targacept has product candidates in development for Alzheimer's disease and cognitive deficits in schizophrenia, pain and depression, and multiple preclinical programs. Targacept is located in Winston-Salem, North Carolina.

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