Bruce D. Given, M.D., President and CEO of
Encysive Pharmaceuticals, Inc. [ENCY] and Rino Aldrighetti, President of Pulmonary Hypertension Association
Ring The NASDAQ Stock Market Opening Bell

Wednesday, November 2, 2005
at NASDAQ's MarketSite
in New York City.

Encysive Pharmaceuticals, Inc. [ENCY] and Pulmonary Hypertension Association

Bruce D. Given, M.D., President and CEO of Encysive Pharmaceuticals, Inc. (NASDAQ: ENCY), and Rino Aldrighetti, President of Pulmonary Hypertension Association (PHA) preside over the opening bell to kick off Pulmonary Hypertension Awareness Month. PHA will also launch its national "Faces of PAH" public awareness and educational campaign at the Opening.

Encysive is committed to the treatment and prevention of inflammatory and cardiovascular diseases, such as pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure in the pulmonary artery. The New Drug Application for the Company's lead drug candidate Thelin™ (sitaxsentan sodium), an endothelin A receptor antagonist for the treatment of PAH, is now under active review by the Cardio-Renal Division of the U.S. Food and Drug Administration.

Click for larger pictures of the NASDAQ MarketSite. Additional Photographs for 11/02/2005 Download Hi-Res Quality Photo of this NASDAQ Market Open - Pictured: Encysive Pharmaceuticals, Inc. [ENCY] and Pulmonary Hypertension Association Rings The NASDAQ Stock Market Opening Bell These photos are Copyright 2005, The Nasdaq Stock Market Inc. and available for re-publication by the news media only. Any commercial use is strictly prohibited without the prior written consent of The Nasdaq Stock Market Inc. © Copyright 2005, The NASDAQ Stock Market, Inc. Reprinted with the permission of The Nasdaq Stock Market, Inc.