TEKLA CAPITAL MANAGEMENT LLC Information

100 FEDERAL STREET, BOSTON, Massachusetts, 02110, (617) 772-8500

Report Date: 03/31/2015

Position Statistics

Total Positions 104
New Positions 20
Increased Positions 48
Decreased Positions 24
Positions with Activity 72
Sold Out Positions 8
Total Mkt Value (in $ millions) 2,526

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.29%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 3.72%
Healthcare 83.79%
Services 4.14%
Technology 3.01%
Transportation
Utilities

104 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▲ Change in Value ($1,000s) Change (%) Shares Held
CELLADON CORP COM -758 Sold Out 0
CLOVIS ONCOLOGY INC COM -4 Sold Out 0
DICERNA PHARMACEUTICALS INC COM -1,891 Sold Out 0
LIGAND PHARMACEUTICALS INC COM NEW -7,395 Sold Out 0
LILLY ELI & CO COM -15,905 Sold Out 0
MEI PHARMA INC COM NEW -402 Sold Out 0
PTC THERAPEUTICS INC COM -6,079 Sold Out 0
SHIRE PLC SPONSORED ADR -74,147 Sold Out 0
ONCOGENEX PHARMACEUTICALS INC COM 364 New 113,100
XENCOR INC COM 453 453 New 20,000
MACROGENICS INC COM 472 New 12,743
ZAFGEN INC COM 478 -478 (50) 13,307
ELEVEN BIOTHERAPEUTICS INC COM 549 -1,160 (67.89) 195,964
SAGE THERAPEUTICS INC COM 1,034 689 200 15,000
IMMUNOMEDICS INC COM 1,055 1,055 New 500,000
BELLICUM PHARMACEUTICALS INC COM 1,192 New 60,000
CELLECTIS S A SPONSORED ADS 1,412 1,412 New 40,000
BIODELIVERY SCIENCES INTL INC COM 1,970 -263 (11.79) 250,000
MYRIAD GENETICS INC COM 2,492 -1,246 (33.33) 74,800
SORRENTO THERAPEUTICS INC COM NEW 2,738 -1,369 (33.33) 142,597