TEKLA CAPITAL MANAGEMENT LLC Information

2 LIBERTY SQUARE, BOSTON, Massachusetts, 02109, (617) 772-8500

Report Date: 12/31/2014

Position Statistics

Total Positions 94
New Positions 8
Increased Positions 24
Decreased Positions 31
Positions with Activity 55
Sold Out Positions 8
Total Mkt Value (in $ millions) 2,246

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.36%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 3.85%
Healthcare 85.72%
Services 4.61%
Technology 2.48%
Transportation
Utilities

94 Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▲ Change in Value ($1,000s) Change (%) Shares Held
ALIGN TECHNOLOGY INC COM -4,249 Sold Out 0
AMARIN CORP PLC SPONS ADR NEW -11,118 Sold Out 0
CELLDEX THERAPEUTICS INC NEW COM -12,791 Sold Out 0
EPIZYME INC COM -2,386 Sold Out 0
NEKTAR THERAPEUTICS COM -3,797 Sold Out 0
PERKINELMER INC COM -8,616 Sold Out 0
THORATEC CORP COM NEW -4,527 Sold Out 0
UNITEDHEALTH GROUP INC COM -9,530 Sold Out 0
CLOVIS ONCOLOGY INC COM 4 -8,524 (99.95) 51
ONCOGENEX PHARMACEUTICALS INC COM 226 New 113,100
SAGE THERAPEUTICS INC COM 289 New 5,000
MACROGENICS INC COM 379 -568 (60) 12,743
MEI PHARMA INC COM NEW 520 New 243,920
ZAFGEN INC COM 915 915 New 26,614
BELLICUM PHARMACEUTICALS INC COM 1,385 1,385 New 60,000
CELLADON CORP COM 1,583 -950 (37.51) 606,482
SAGENT PHARMACEUTICALS INC COM 2,015 -7,524 (78.88) 85,500
SORRENTO THERAPEUTICS INC COM NEW 2,293 2,293 New 213,896
BIODELIVERY SCIENCES INTL INC COM 2,301 -1,771 (43.49) 283,411
DICERNA PHARMACEUTICALS INC COM 3,019 3,019 New 156,250


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