TEKLA CAPITAL MANAGEMENT LLC Information

2 LIBERTY SQUARE, BOSTON, Massachusetts, 02109, (617) 772-8500

Report Date: 12/31/2014

Position Statistics

Total Positions 94
New Positions 8
Increased Positions 24
Decreased Positions 31
Positions with Activity 55
Sold Out Positions 8
Total Mkt Value (in $ millions) 2,335

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.38%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 3.83%
Healthcare 85.48%
Services 4.65%
Technology 2.33%
Transportation
Utilities

94 Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held ▲
ALIGN TECHNOLOGY INC COM -3,715 Sold Out 0
AMARIN CORP PLC SPONS ADR NEW -13,375 Sold Out 0
CELLDEX THERAPEUTICS INC NEW COM -14,108 Sold Out 0
EPIZYME INC COM -2,702 Sold Out 0
NEKTAR THERAPEUTICS COM -4,061 Sold Out 0
PERKINELMER INC COM -8,511 Sold Out 0
THORATEC CORP COM NEW -4,967 Sold Out 0
UNITEDHEALTH GROUP INC COM -10,115 Sold Out 0
CLOVIS ONCOLOGY INC COM 5 -9,463 (99.95) 51
SAGE THERAPEUTICS INC COM 307 New 5,000
MACROGENICS INC COM 428 -642 (60) 12,743
RECEPTOS INC COM 3,427 3,427 New 20,400
ZAFGEN INC COM 987 987 New 26,614
AGIOS PHARMACEUTICALS INC COM 4,929 1,195 32 46,200
BLUEBIRD BIO INC COM 7,303 -15,857 (68.47) 54,527
IDEXX LABS INC COM 8,552 New 56,265
ISHARES TR NASDQ BIOTEC ETF 20,848 -7,846 (27.35) 57,670
BELLICUM PHARMACEUTICALS INC COM 1,557 1,557 New 60,000
ALNYLAM PHARMACEUTICALS INC COM 7,476 New 61,595
PERRIGO CO PLC SHS 12,527 New 62,952