TEKLA CAPITAL MANAGEMENT LLC Information

100 FEDERAL STREET, BOSTON, Massachusetts, 02110, (617) 772-8500

Report Date: 03/31/2015

Position Statistics

Total Positions 105
New Positions 20
Increased Positions 48
Decreased Positions 24
Positions with Activity 72
Sold Out Positions 8
Total Mkt Value (in $ millions) 2,507

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.14%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 3.95%
Healthcare 82.6%
Services 5.15%
Technology 3.01%
Transportation
Utilities

105 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) ▲ Shares Held
CELLADON CORP COM -758 Sold Out 0
CLOVIS ONCOLOGY INC COM -4 Sold Out 0
DICERNA PHARMACEUTICALS INC COM -2,208 Sold Out 0
LIGAND PHARMACEUTICALS INC COM NEW -6,823 Sold Out 0
LILLY ELI & CO COM -16,101 Sold Out 0
MEI PHARMA INC COM NEW -432 Sold Out 0
PTC THERAPEUTICS INC COM -5,699 Sold Out 0
SHIRE PLC SPONSORED ADR -69,274 Sold Out 0
ELEVEN BIOTHERAPEUTICS INC COM 562 -1,189 (67.89) 195,964
MOMENTA PHARMACEUTICALS INC COM 7,521 -15,187 (66.88) 353,575
KYTHERA BIOPHARMACEUTICALS INC COM 4,175 -4,175 (50) 55,717
ZAFGEN INC COM 465 -465 (50) 13,307
NEUROCRINE BIOSCIENCES INC COM 23,709 -23,617 (49.9) 501,150
JAZZ PHARMACEUTICALS PLC SHS USD 21,416 -14,296 (40.03) 120,741
VERTEX PHARMACEUTICALS INC COM 60,937 -31,201 (33.86) 464,244
MYRIAD GENETICS INC COM 2,586 -1,293 (33.33) 74,800
SORRENTO THERAPEUTICS INC COM NEW 2,379 -1,189 (33.33) 142,597
SAREPTA THERAPEUTICS INC COM 6,941 -3,469 (33.32) 230,300
BIODELIVERY SCIENCES INTL INC COM 1,948 -260 (11.79) 250,000
AMGEN INC COM 53,914 -4,368 (7.49) 351,779