TEKLA CAPITAL MANAGEMENT LLC Information

100 FEDERAL STREET, BOSTON, Massachusetts, 02110, (617) 772-8500

Report Date: 03/31/2015

Position Statistics

Total Positions 105
New Positions 19
Increased Positions 47
Decreased Positions 25
Positions with Activity 72
Sold Out Positions 8
Total Mkt Value (in $ millions) 2,484

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.92%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 3.82%
Healthcare 83.04%
Services 5.28%
Technology 2.97%
Transportation
Utilities

105 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) ▲ Shares Held
CELLADON CORP COM -1,365 Sold Out 0
CLOVIS ONCOLOGY INC COM -4 Sold Out 0
DICERNA PHARMACEUTICALS INC COM -2,611 Sold Out 0
LIGAND PHARMACEUTICALS INC COM NEW -5,858 Sold Out 0
LILLY ELI & CO COM -14,570 Sold Out 0
MEI PHARMA INC COM NEW -478 Sold Out 0
PTC THERAPEUTICS INC COM -6,798 Sold Out 0
SHIRE PLC SPONSORED ADR -71,766 Sold Out 0
ELEVEN BIOTHERAPEUTICS INC COM 566 -1,197 (67.89) 195,964
MOMENTA PHARMACEUTICALS INC COM 7,457 -15,058 (66.88) 353,575
KYTHERA BIOPHARMACEUTICALS INC COM 2,967 -2,967 (50) 55,717
ZAFGEN INC COM 437 -437 (50) 13,307
NEUROCRINE BIOSCIENCES INC COM 21,224 -21,141 (49.9) 501,150
JAZZ PHARMACEUTICALS PLC SHS USD 21,940 -14,646 (40.03) 120,741
VERTEX PHARMACEUTICALS INC COM 57,938 -29,665 (33.86) 464,244
MYRIAD GENETICS INC COM 2,460 -1,230 (33.33) 74,800
SORRENTO THERAPEUTICS INC COM NEW 1,965 -983 (33.33) 142,597
SAREPTA THERAPEUTICS INC COM 5,799 -2,898 (33.32) 230,300
BIODELIVERY SCIENCES INTL INC COM 1,965 -263 (11.79) 250,000
SYNAGEVA BIOPHARMA CORP COM 43,332 -5,306 (10.91) 198,689


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