TEKLA CAPITAL MANAGEMENT LLC Information

100 FEDERAL STREET, BOSTON, Massachusetts, 02110, (617) 772-8500

Report Date: 03/31/2015

Position Statistics

Total Positions 105
New Positions 19
Increased Positions 47
Decreased Positions 25
Positions with Activity 72
Sold Out Positions 8
Total Mkt Value (in $ millions) 2,454

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.95%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 3.79%
Healthcare 82.98%
Services 5.3%
Technology 3.01%
Transportation
Utilities

105 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) ▲ Change (%) Shares Held
SHIRE PLC SPONSORED ADR -72,115 Sold Out 0
VERTEX PHARMACEUTICALS INC COM 56,930 -29,149 (33.86) 464,244
NEUROCRINE BIOSCIENCES INC COM 21,199 -21,116 (49.9) 501,150
JAZZ PHARMACEUTICALS PLC SHS USD 21,628 -14,438 (40.03) 120,741
LILLY ELI & CO COM -13,890 Sold Out 0
MOMENTA PHARMACEUTICALS INC COM 6,856 -13,844 (66.88) 353,575
PTC THERAPEUTICS INC COM -6,497 Sold Out 0
LIGAND PHARMACEUTICALS INC COM NEW -6,171 Sold Out 0
REGENERON PHARMACEUTICALS COM 94,824 -5,674 (5.65) 187,166
SYNAGEVA BIOPHARMA CORP COM 42,518 -5,207 (10.91) 198,689
AMGEN INC COM 55,936 -4,532 (7.49) 351,779
BIOMARIN PHARMACEUTICAL INC COM 68,001 -4,455 (6.15) 534,977
SAREPTA THERAPEUTICS INC COM 6,151 -3,074 (33.32) 230,300
KYTHERA BIOPHARMACEUTICALS INC COM 2,654 -2,654 (50) 55,717
DICERNA PHARMACEUTICALS INC COM -2,598 Sold Out 0
MYRIAD GENETICS INC COM 2,591 -1,296 (33.33) 74,800
CELLADON CORP COM -1,261 Sold Out 0
ELEVEN BIOTHERAPEUTICS INC COM 572 -1,210 (67.89) 195,964
SORRENTO THERAPEUTICS INC COM NEW 1,841 -920 (33.33) 142,597
MEI PHARMA INC COM NEW -441 Sold Out 0


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