TEKLA CAPITAL MANAGEMENT LLC Information

100 FEDERAL STREET, BOSTON, Massachusetts, 02110, (617) 772-8500

Report Date: 12/31/2015

Position Statistics

Total Positions 142
New Positions 12
Increased Positions 44
Decreased Positions 39
Positions with Activity 83
Sold Out Positions 14
Total Mkt Value (in $ millions) 2,317

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.01%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 4.75%
Healthcare 79.71%
Services 4.18%
Technology 5.06%
Transportation
Utilities

142 Positions as of 12/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
JUNO THERAPEUTICS INC COM 7,697 New 182,000
ICON PLC SHS 7,667 2,863 59.58 114,900
CENTENE CORP DEL COM 7,544 New 120,000
PIERIS PHARMACEUTICALS INC COM 7,350 New 3,848,191
ANACOR PHARMACEUTICALS INC COM 7,271 2,950 68.25 110,038
NOVARTIS A G SPONSORED ADR 7,123 New 92,700
INTRA CELLULAR THERAPIES INC COM 6,588 1,326 25.20 187,800
LILLY ELI & CO COM 6,575 New 85,667
ENDOLOGIX INC COM 6,337 New 551,000
MERRIMACK PHARMACEUTICALS INC COM 6,216 New 853,787
ULTRAGENYX PHARMACEUTICAL INC COM 6,140 New 88,400
FLAMEL TECHNOLOGIES SA SPONSORED ADR 5,843 5,843 New 474,288
HEALTHCARE RLTY TR COM 5,763 New 187,224
CELLECTIS S A SPONSORED ADS 5,733 1,352 30.86 207,250
ARDELYX INC COM 5,230 -7 (0.14) 639,370
TENET HEALTHCARE CORP COM NEW 5,205 New 164,500
EXELIXIS INC COM 4,935 4,935 New 1,023,877
HERON THERAPEUTICS INC COM 4,890 New 219,000
COMMUNITY HEALTH SYS INC NEW COM 4,792 1,494 45.28 304,472
KARYOPHARM THERAPEUTICS INC COM 4,763 -3,985 (45.55) 500,324


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