TEKLA CAPITAL MANAGEMENT LLC Information

100 FEDERAL STREET, BOSTON, Massachusetts, 02110, (617) 772-8500

Report Date: 12/31/2015

Position Statistics

Total Positions 141
New Positions 12
Increased Positions 43
Decreased Positions 39
Positions with Activity 82
Sold Out Positions 14
Total Mkt Value (in $ millions) 2,360

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.01%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 4.88%
Healthcare 79.77%
Services 4.1%
Technology 5.09%
Transportation
Utilities

12 New Positions as of 12/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SANOFI SPONSORED ADR 13,069 13,069 New 305,000
CEPHEID COM 11,809 11,809 New 333,590
UNIVERSAL HLTH SVCS INC CL B 9,484 9,484 New 70,300
FLAMEL TECHNOLOGIES SA SPONSORED ADR 5,677 5,677 New 474,288
RETROPHIN INC COM 4,665 4,665 New 329,949
EXELIXIS INC COM 4,648 4,648 New 1,023,877
CYTOMX THERAPEUTICS INC COM 4,202 4,202 New 328,059
HALOZYME THERAPEUTICS INC COM 2,168 2,168 New 200,000
INSMED INC COM PAR $.01 1,951 1,951 New 156,600
NOVAVAX INC COM 1,951 1,951 New 358,000
NEVRO CORP COM 1,681 1,681 New 25,000
TETRAPHASE PHARMACEUTICALS INC COM 1,087 1,087 New 192,322