TEKLA CAPITAL MANAGEMENT LLC Information

2 LIBERTY SQUARE, BOSTON, Massachusetts, 02109, (617) 772-8500

Report Date: 12/31/2014

Position Statistics

Total Positions 94
New Positions 8
Increased Positions 24
Decreased Positions 31
Positions with Activity 55
Sold Out Positions 8
Total Mkt Value (in $ millions) 2,359

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.39%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 3.77%
Healthcare 85.7%
Services 4.58%
Technology 2.32%
Transportation
Utilities

24 INCREASED Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BIOGEN INC COM 131,473 56,440 75.22 327,283
REGENERON PHARMACEUTICALS COM 95,234 5,377 5.98 198,366
ALEXION PHARMACEUTICALS INC COM 85,917 4,538 5.58 477,105
SHIRE PLC SPONSORED ADR 71,819 40,358 128.28 281,522
AKORN INC COM 46,925 8,292 21.46 849,482
ABBVIE INC COM 39,260 7,466 23.48 594,219
JAZZ PHARMACEUTICALS PLC SHS USD 38,138 5,323 16.22 201,341
VENTAS INC COM 21,320 11,389 114.68 292,782
ALLSCRIPTS HEALTHCARE SOLUTNS COM 20,202 20,202 New 1,604,600
PHYSICIANS RLTY TR COM 16,861 5,039 42.62 958,002
OMEGA HEALTHCARE INVS INC COM 14,503 4,770 49.01 376,416
MEDICAL PPTYS TRUST INC COM 14,359 5,157 56.04 978,774
SABRA HEALTH CARE REIT INC COM 12,738 2,014 18.78 407,890
HCA HOLDINGS INC COM 11,466 2,472 27.49 147,488
PTC THERAPEUTICS INC COM 8,398 2,819 50.54 119,150
ELEVEN BIOTHERAPEUTICS INC COM 6,828 6,828 New 610,200
AGIOS PHARMACEUTICALS INC COM 4,945 1,199 32 46,200
KARYOPHARM THERAPEUTICS INC COM 4,338 1,127 35.11 137,766
WRIGHT MED GROUP INC COM 4,099 4,099 New 156,100
DICERNA PHARMACEUTICALS INC COM 3,778 3,778 New 156,250