TEKLA CAPITAL MANAGEMENT LLC Information

100 FEDERAL STREET, BOSTON, Massachusetts, 02110, (617) 772-8500

Report Date: 12/31/2015

Position Statistics

Total Positions 141
New Positions 12
Increased Positions 43
Decreased Positions 39
Positions with Activity 82
Sold Out Positions 14
Total Mkt Value (in $ millions) 2,300

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.01%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 4.79%
Healthcare 79.75%
Services 4.16%
Technology 5.03%
Transportation
Utilities

39 DECREASED Positions as of 12/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BIOGEN INC COM 123,892 -4,579 (3.56) 450,533
TEVA PHARMACEUTICAL INDS LTD ADR 72,649 -2,796 (3.71) 1,334,237
MYLAN N V SHS EURO 22,159 -62,749 (73.9) 531,252
ALKERMES PLC SHS 20,290 -26,051 (56.22) 510,444
BRISTOL MYERS SQUIBB CO COM 14,624 -24,010 (62.15) 202,600
MEDICINES CO COM 14,306 -7,913 (35.61) 401,970
NEUROCRINE BIOSCIENCES INC COM 14,196 -2,935 (17.13) 311,460
MEDTRONIC PLC SHS 9,842 -6,546 (39.94) 124,344
UNITED THERAPEUTICS CORP DEL COM 9,794 -9,415 (49.01) 93,100
ALNYLAM PHARMACEUTICALS INC COM 9,218 -9,652 (51.15) 137,495
ENDO INTL PLC SHS 7,731 -917 (10.61) 286,348
ARDELYX INC COM 5,121 -7 (0.14) 639,370
KARYOPHARM THERAPEUTICS INC COM 4,653 -3,892 (45.55) 500,324
AURIS MED HLDG AG COM 4,642 -3,063 (39.76) 1,268,263
MALLINCKRODT PUB LTD CO SHS 3,870 -681 (14.97) 61,900
AKORN INC COM 3,696 -17,923 (82.9) 145,235
SAGENT PHARMACEUTICALS INC COM 3,337 -1,430 (30) 286,650
LEXICON PHARMACEUTICALS INC COM NEW 2,729 -2,158 (44.15) 197,641
GW PHARMACEUTICALS PLC ADS 2,431 -5,185 (68.09) 30,000
ALLSCRIPTS HEALTHCARE SOLUTNS COM 2,326 -21,502 (90.24) 173,600


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