TEKLA CAPITAL MANAGEMENT LLC Information

2 LIBERTY SQUARE, BOSTON, Massachusetts, 02109, (617) 772-8500

Report Date: 12/31/2014

Position Statistics

Total Positions 94
New Positions 8
Increased Positions 24
Decreased Positions 31
Positions with Activity 55
Sold Out Positions 8
Total Mkt Value (in $ millions) 2,238

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.37%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 3.84%
Healthcare 85.68%
Services 4.66%
Technology 2.49%
Transportation
Utilities

55 Activity Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
CELGENE CORP COM 220,529 -4,599 (2.04) 1,994,834
GILEAD SCIENCES INC COM 218,498 -43,033 (16.45) 2,080,731
BIOGEN INC COM 126,403 54,264 75.22 327,283
REGENERON PHARMACEUTICALS COM 93,462 5,277 5.98 198,366
INCYTE CORP COM 92,035 -20,197 (18) 936,461
ALEXION PHARMACEUTICALS INC COM 82,301 4,347 5.58 477,105
SHIRE PLC SPONSORED ADR 68,663 38,585 128.28 281,522
BIOMARIN PHARMACEUTICAL INC COM 66,078 -16,287 (19.77) 570,027
AMGEN INC COM 60,982 -20,809 (25.44) 380,279
PFIZER INC COM 55,831 -8,997 (13.88) 1,638,241
ABBVIE INC COM 38,220 7,268 23.48 594,219
AKORN INC COM 36,528 6,454 21.46 849,482
JAZZ PHARMACEUTICALS PLC SHS USD 36,390 5,079 16.22 201,341
AETNA INC NEW COM 36,005 -6,194 (14.68) 331,931
NEUROCRINE BIOSCIENCES INC COM 35,522 -10,000 (21.97) 1,000,350
TEVA PHARMACEUTICAL INDS LTD ADR 26,335 -14,212 (35.05) 423,594
ENDO INTL PLC SHS 21,413 -7,182 (25.12) 251,773
ALLSCRIPTS HEALTHCARE SOLUTNS COM 21,341 21,341 New 1,604,600
VENTAS INC COM 20,302 10,845 114.68 292,782
ILLUMINA INC COM 19,858 -23,999 (54.72) 103,841