TEKLA CAPITAL MANAGEMENT LLC Information

100 FEDERAL STREET, BOSTON, Massachusetts, 02110, (617) 772-8500

Report Date: 12/31/2015

Position Statistics

Total Positions 141
New Positions 12
Increased Positions 43
Decreased Positions 39
Positions with Activity 82
Sold Out Positions 14
Total Mkt Value (in $ millions) 2,300

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.01%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial 4.79%
Healthcare 79.75%
Services 4.16%
Technology 5.03%
Transportation
Utilities

82 Activity Positions as of 12/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
GILEAD SCIENCES INC COM 205,638 9,685 4.94 2,331,231
BIOGEN INC COM 123,892 -4,579 (3.56) 450,533
ALLERGAN PLC SHS 88,700 19,902 28.93 409,586
VERTEX PHARMACEUTICALS INC COM 87,166 1,990 2.34 1,033,503
TEVA PHARMACEUTICAL INDS LTD ADR 72,649 -2,796 (3.71) 1,334,237
ILLUMINA INC COM 58,632 17,954 44.14 434,341
UNITEDHEALTH GROUP INC COM 53,870 12,707 30.87 409,100
BIOMARIN PHARMACEUTICAL INC COM 50,482 2,174 4.50 596,145
MEDIVATION INC COM 38,570 26,698 224.88 667,300
HCA HOLDINGS INC COM 36,157 16,551 84.42 448,488
SHIRE PLC SPONSORED ADR 32,201 22,921 247.01 171,813
AGILENT TECHNOLOGIES INC COM 29,816 3,806 14.63 728,650
MYLAN N V SHS EURO 22,159 -62,749 (73.9) 531,252
ACADIA PHARMACEUTICALS COM 20,591 2,423 13.33 637,500
ALKERMES PLC SHS 20,290 -26,051 (56.22) 510,444
ST JUDE MED INC COM 19,493 7,186 58.39 255,810
BRISTOL MYERS SQUIBB CO COM 14,624 -24,010 (62.15) 202,600
MEDICINES CO COM 14,306 -7,913 (35.61) 401,970
NEUROCRINE BIOSCIENCES INC COM 14,196 -2,935 (17.13) 311,460
MCKESSON CORP COM 13,906 2,517 22.10 82,862


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