PALO ALTO INVESTORS, LLC Information

470 UNIVERSITY AVE, PALO ALTO, California, 94301, (650) 325-0772

Report Date: 03/31/2016

Position Statistics

Total Positions 44
New Positions 1
Increased Positions 11
Decreased Positions 7
Positions with Activity 18
Sold Out Positions 0
Total Mkt Value (in $ millions) 1,415

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 95.13%
Services
Technology
Transportation
Utilities

44 Positions as of 03/31/2016

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ABIOMED INC COM 231,991 -56,208 (19.5) 2,325,959
ANACOR PHARMACEUTICALS INC COM 220,639 3,162 1.45 2,219,042
UNITED THERAPEUTICS CORP DEL COM 179,692 824 .46 1,525,654
BIOMARIN PHARMACEUTICAL INC COM 119,412 312 .26 1,340,347
AMAG PHARMACEUTICALS INC COM 60,914 1,476 2.48 2,906,194
CLOVIS ONCOLOGY INC COM 57,805 -1,442 (2.43) 3,461,365
INSMED INC COM PAR $.01 56,675 New 4,790,800
VANDA PHARMACEUTICALS INC COM 42,768 New 4,030,908
WRIGHT MED GROUP N V ORD SHS 0.03 PAR 42,307 1,135 2.76 2,190,957
PROTHENA CORP PLC SHS 32,383 New 695,518
MEDIVATION INC COM 31,859 946 3.06 525,462
KARYOPHARM THERAPEUTICS INC COM 29,804 -139 (0.47) 3,098,145
EPIZYME INC COM 28,839 -60 (0.21) 2,655,479
CELGENE CORP COM 28,821 New 270,800
GILEAD SCIENCES INC COM 25,995 New 302,900
AMICUS THERAPEUTICS INC COM 25,071 New 3,551,173
CEMPRA INC COM 22,201 732 3.41 1,215,833
SHIRE PLC SPONSORED ADR 19,836 262 1.34 106,100
ARIAD PHARMACEUTICALS INC COM 18,459 -73 (0.39) 2,248,317
ACADIA PHARMACEUTICALS COM 17,274 17,274 New 485,100


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