PALO ALTO INVESTORS, LLC Information

470 UNIVERSITY AVE, PALO ALTO, California, 94301, (650) 325-0772

Report Date: 12/31/2014

Position Statistics

Total Positions 45
New Positions 4
Increased Positions 28
Decreased Positions 10
Positions with Activity 38
Sold Out Positions 2
Total Mkt Value (in $ millions) 1,977

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 2.78%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 95.74%
Services
Technology
Transportation
Utilities

45 Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
UNITED THERAPEUTICS CORP DEL COM 259,845 19,315 8.03 1,403,128
CLOVIS ONCOLOGY INC COM 181,161 32,832 22.13 2,102,857
ANACOR PHARMACEUTICALS INC COM 171,887 27,616 19.14 2,521,822
ABIOMED INC COM 165,542 2,059 1.26 2,460,124
BIOMARIN PHARMACEUTICAL INC COM 157,449 4,570 2.99 1,302,197
ENDO INTL PLC SHS 157,387 1,963 1.26 1,686,164
AMAG PHARMACEUTICALS INC COM 114,108 21,724 23.52 1,994,200
INSMED INC COM PAR $.01 104,678 16,598 18.84 4,625,648
CYBERONICS INC COM 101,487 -820 (0.8) 1,608,101
KYTHERA BIOPHARMACEUTICALS INC COM 54,927 965 1.79 1,121,884
WRIGHT MED GROUP INC COM 52,789 31,238 144.95 2,039,751
SEQUENOM INC COM NEW 42,482 493 1.18 9,925,742
VANDA PHARMACEUTICALS INC COM 37,490 4,987 15.35 3,786,908
MOMENTA PHARMACEUTICALS INC COM 25,567 New 1,455,176
PROTHENA CORP PLC SHS 24,877 626 2.58 691,218
CELGENE CORP COM 24,453 4,981 25.58 215,500
STAAR SURGICAL CO COM PAR $0.01 23,930 274 1.16 2,629,622
GILEAD SCIENCES INC COM 23,784 6,803 40.06 234,600
AMICUS THERAPEUTICS INC COM 23,477 New 1,956,376
CELLADON CORP COM 23,198 -882 (3.67) 1,403,800


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