PALO ALTO INVESTORS, LLC Information

470 UNIVERSITY AVE, PALO ALTO, California, 94301, (650) 325-0772

Report Date: 12/31/2015

Position Statistics

Total Positions 46
New Positions 1
Increased Positions 19
Decreased Positions 10
Positions with Activity 29
Sold Out Positions 3
Total Mkt Value (in $ millions) 1,379

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 95.04%
Services
Technology
Transportation
Utilities

46 Positions as of 12/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ABIOMED INC COM 288,777 6,246 2.21 2,889,505
UNITED THERAPEUTICS CORP DEL COM 159,216 -587 (0.37) 1,518,654
ANACOR PHARMACEUTICALS INC COM 144,927 -25,968 (15.2) 2,187,242
BIOMARIN PHARMACEUTICAL INC COM 113,766 -28,053 (19.78) 1,336,847
AMAG PHARMACEUTICALS INC COM 77,786 1,602 2.10 2,835,792
INSMED INC COM PAR $.01 59,693 274 .46 4,790,800
CLOVIS ONCOLOGY INC COM 51,371 6,355 14.12 3,547,719
WRIGHT MED GROUP N V ORD SHS 0.03 PAR 40,895 237 .58 2,132,157
VANDA PHARMACEUTICALS INC COM 36,943 310 .85 4,030,908
PROTHENA CORP PLC SHS 29,935 -17 (0.06) 695,518
EPIZYME INC COM 29,430 6,031 25.78 2,660,979
GILEAD SCIENCES INC COM 29,381 -1,358 (4.42) 302,900
KARYOPHARM THERAPEUTICS INC COM 29,259 253 .87 3,112,645
CELGENE CORP COM 29,255 New 270,800
MEDIVATION INC COM 28,639 New 509,862
AMICUS THERAPEUTICS INC COM 27,522 12,220 79.86 3,551,173
ENDO INTL PLC SHS 22,651 New 801,230
STAAR SURGICAL CO COM PAR $0.01 20,480 183 .90 2,666,722
CEMPRA INC COM 20,446 20,446 New 1,175,733
SHIRE PLC SPONSORED ADR 18,947 New 104,700