BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2015

Position Statistics

Total Positions 126
New Positions 12
Increased Positions 39
Decreased Positions 12
Positions with Activity 51
Sold Out Positions 4
Total Mkt Value (in $ millions) 8,350

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.77%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.24%
Services
Technology
Transportation
Utilities

126 Positions as of 09/30/2015

Company Class Value of Shares ($1,000s) ▲ Change in Value ($1,000s) Change (%) Shares Held
BIOTA PHARMACEUTIALS INC COM -1,379 Sold Out 0
VANDA PHARMACEUTICALS INC COM -3,611 Sold Out 0
XOMA CORP DEL COM -13,832 Sold Out 0
ZIOPHARM ONCOLOGY INC COM -1,013 Sold Out 0
BIOTIME INC WT EXP 100118 13 New 20,084
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 53 New 13,253
APTOSE BIOSCIENCES INC COM NEW 97 New 33,397
CHEMOCENTRYX INC COM 182 New 49,064
SYNERGY PHARMACEUTICALS DEL COM NEW 256 256 New 67,100
FOUNDATION MEDICINE INC COM 319 New 20,892
ACHAOGEN INC COM 383 New 100,000
UNIQURE NV SHS 497 New 30,000
RITTER PHARMACEUTICALS INC COM 510 New 400,000
TRILLIUM THERAPEUTICS INC COM NEW 543 543 New 63,014
ARBUTUS BIOPHARMA CORP COM 572 New 180,582
ALDEYRA THERAPEUTICS INC COM 611 New 142,000
DISCOVERY LABORATORIES INC NEW COM PAR 640 New 254,980
FIVE PRIME THERAPEUTICS INC COM 640 New 19,247
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 755 New 100,000
BELLEROPHON THERAPEUTICS INC COM 759 6 .84 352,928


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