BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2016

Position Statistics

Total Positions 125
New Positions 5
Increased Positions 34
Decreased Positions 13
Positions with Activity 47
Sold Out Positions 5
Total Mkt Value (in $ millions) 8,974

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.63%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 91.05%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2016

Company Class Value of Shares ($1,000s) ▲ Change in Value ($1,000s) Change (%) Shares Held
FLEXION THERAPEUTICS INC COM -1,554 Sold Out 0
GILEAD SCIENCES INC COM -20,832 Sold Out 0
MARINUS PHARMACEUTICALS INC COM -1,026 Sold Out 0
OHR PHARMACEUTICAL INC COM NEW -1,148 Sold Out 0
SHIRE PLC SPONSORED ADR -1,546,993 Sold Out 0
BIOTIME INC WT EXP 100118 10 New 20,084
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 61 New 13,253
APTOSE BIOSCIENCES INC COM NEW 91 New 33,397
CHEMOCENTRYX INC COM 214 New 49,064
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 219 New 13,746
ACHAOGEN INC COM 285 New 100,000
FOUNDATION MEDICINE INC COM 364 New 20,892
BIODELIVERY SCIENCES INTL INC COM 422 New 210,021
CHIMERIX INC COM 545 New 115,216
WINDTREE THERAPEUTICS INC COM 620 (0) 254,973
ALNYLAM PHARMACEUTICALS INC COM 636 New 11,340
RITTER PHARMACEUTICALS INC COM 640 New 400,000
ARBUTUS BIOPHARMA CORP COM 728 New 180,582
ALDEYRA THERAPEUTICS INC COM 728 New 142,000
FIVE PRIME THERAPEUTICS INC COM 840 New 19,247