BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 102
New Positions 8
Increased Positions 28
Decreased Positions 18
Positions with Activity 46
Sold Out Positions 6
Total Mkt Value (in $ millions) 7,527

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.04%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.1%
Services
Technology
Transportation
Utilities

102 Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held ▲
AEGERION PHARMACEUTICALS INC COM -9,653 Sold Out 0
ASTERIAS BIOTHERAPEUTICS INC COM SER A -66 Sold Out 0
BIOTIME INC WT EXP 100118 -26 Sold Out 0
CLOVIS ONCOLOGY INC COM -52,416 Sold Out 0
GALECTIN THERAPEUTICS INC COM NEW -1,035 Sold Out 0
REGADO BIOSCIENCES INC COM -452 Sold Out 0
SALIX PHARMACEUTICALS INC COM 1,165 -16,906 (93.55) 8,621
ALNYLAM PHARMACEUTICALS INC COM 1,084 New 11,600
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 80 New 13,253
FIVE PRIME THERAPEUTICS INC COM 519 New 19,823
RECEPTOS INC COM 2,694 New 23,900
ACCELERON PHARMA INC COM 1,131 New 28,765
UNIQURE NV SHS 646 New 30,672
TESARO INC COM 1,280 New 31,218
OPHTHOTECH CORP COM 2,053 New 36,776
CHEMOCENTRYX INC COM 441 New 50,000
LIGAND PHARMACEUTICALS INC COM NEW 4,186 New 73,400
SAGE THERAPEUTICS INC COM 3,030 3,030 New 75,000
ENANTA PHARMACEUTICALS INC COM 3,289 New 75,357
FOUNDATION MEDICINE INC COM 3,760 New 78,162