BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2015

Position Statistics

Total Positions 127
New Positions 5
Increased Positions 30
Decreased Positions 12
Positions with Activity 42
Sold Out Positions 7
Total Mkt Value (in $ millions) 9,398

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.69%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.09%
Services
Technology
Transportation
Utilities

127 Positions as of 12/31/2015

Company ▲ Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 872,474 New 14,373,538
ACADIA PHARMACEUTICALS COM 668,309 New 20,481,442
ACCELERON PHARMA INC COM 883 New 28,765
ACHAOGEN INC COM 342 New 100,000
ACHILLION PHARMACEUTICALS INC COM 17,740 New 2,000,000
ACORDA THERAPEUTICS INC COM 103,501 71,790 226.39 3,580,112
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 942 New 100,000
ADVANCED ACCELERATOR APPLIC SPONSORED ADS 19,515 19,515 New 567,454
AERIE PHARMACEUTICALS INC COM 4,781 New 299,356
AFFIMED N V COM 1,728 New 400,000
AGIOS PHARMACEUTICALS INC COM 5,091 New 100,000
AIMMUNE THERAPEUTICS INC COM 3,515 New 250,000
AKARI THERAPEUTICS PLC SPONSORED ADR 6,730 New 395,882
ALCOBRA LTD SHS 9,719 2,897 42.47 2,336,359
ALDER BIOPHARMACEUTICALS INC COM -14,443 Sold Out 0
ALDEYRA THERAPEUTICS INC COM 865 New 142,000
ALEXION PHARMACEUTICALS INC COM 986,493 New 6,542,599
ALKERMES PLC SHS 10,153 10,153 New 250,251
ALNYLAM PHARMACEUTICALS INC COM 778 New 11,340
AMARIN CORP PLC SPONS ADR NEW 4,081 New 2,205,710


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