BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 110
New Positions 14
Increased Positions 28
Decreased Positions 13
Positions with Activity 41
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,810

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.05%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 94.91%
Services
Technology
Transportation
Utilities

110 Positions as of 12/31/2014

Company Class ▲ Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ACADIA PHARMACEUTICALS COM 639,021 New 20,481,442
ACCELERON PHARMA INC COM 1,058 New 28,765
ACHAOGEN INC COM 921 New 100,000
ACHILLION PHARMACEUTICALS INC COM 4,458 New 438,337
ACORDA THERAPEUTICS INC COM 25,409 72 .28 755,534
AERIE PHARMACEUTICALS INC COM 8,960 New 299,356
AFFIMED N V COM 2,476 New 400,000
AGIOS PHARMACEUTICALS INC COM 15,173 -604 (3.83) 163,393
ALDER BIOPHARMACEUTICALS INC COM 4,257 New 153,350
ALNYLAM PHARMACEUTICALS INC COM 1,181 New 11,600
AMICUS THERAPEUTICS INC COM 5,130 New 481,697
ANACOR PHARMACEUTICALS INC COM 217,257 New 4,204,702
AQUINOX PHARMACEUTICALS INC COM 10,772 -13 (0.12) 1,210,350
ARRAY BIOPHARMA INC COM 10,381 New 1,433,797
AURINIA PHARMACEUTICALS INC COM 3,347 New 727,669
BELLICUM PHARMACEUTICALS INC COM 99,383 99,383 New 4,283,732
BIOCRYST PHARMACEUTICALS COM 86,781 New 10,713,686
BIODELIVERY SCIENCES INTL INC COM 2,938 New 210,021
BIOMARIN PHARMACEUTICAL INC COM 429,407 155,334 56.68 3,713,950
BIOTA PHARMACEUTIALS INC COM 2,513 New 1,106,910