BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 110
New Positions 14
Increased Positions 28
Decreased Positions 13
Positions with Activity 41
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,544

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.02%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 94.87%
Services
Technology
Transportation
Utilities

110 Positions as of 12/31/2014

Company Class ▲ Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ACADIA PHARMACEUTICALS COM 777,680 New 20,481,442
ACCELERON PHARMA INC COM 1,169 New 28,765
ACHAOGEN INC COM 1,117 New 100,000
ACHILLION PHARMACEUTICALS INC COM 5,321 New 438,337
ACORDA THERAPEUTICS INC COM 25,567 73 .28 755,534
AERIE PHARMACEUTICALS INC COM 8,418 New 299,356
AFFIMED N V COM 2,468 New 400,000
AGIOS PHARMACEUTICALS INC COM 17,529 -697 (3.83) 163,393
ALDER BIOPHARMACEUTICALS INC COM 4,122 New 153,350
ALNYLAM PHARMACEUTICALS INC COM 1,178 New 11,600
AMICUS THERAPEUTICS INC COM 4,220 New 481,697
ANACOR PHARMACEUTICALS INC COM 182,905 New 4,204,702
AQUINOX PHARMACEUTICALS INC COM 11,801 -15 (0.12) 1,210,350
ARRAY BIOPHARMA INC COM 11,413 New 1,433,797
AURINIA PHARMACEUTICALS INC COM 3,420 New 727,669
BELLICUM PHARMACEUTICALS INC COM 99,468 99,468 New 4,283,732
BIOCRYST PHARMACEUTICALS COM 109,280 New 10,713,686
BIODELIVERY SCIENCES INTL INC COM 3,149 New 210,021
BIOMARIN PHARMACEUTICAL INC COM 397,653 143,847 56.68 3,713,950
BIOTA PHARMACEUTIALS INC COM 2,789 New 1,106,910


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