BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 10,857

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.16%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.09%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class ▲ Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 2,458,918 -24,367 (0.98) 36,049,228
ACADIA PHARMACEUTICALS COM 853,871 New 20,481,442
ACCELERON PHARMA INC COM 857 New 28,765
ACHAOGEN INC COM 584 New 100,000
ACHILLION PHARMACEUTICALS INC COM 1,838 -1,923 (51.13) 214,237
ACORDA THERAPEUTICS INC COM 23,704 -533 (2.2) 738,916
AEGERION PHARMACEUTICALS INC COM 266 266 New 14,300
AERIE PHARMACEUTICALS INC COM 5,173 New 299,356
AFFIMED N V COM 5,800 New 400,000
AGIOS PHARMACEUTICALS INC COM 16,561 -1,484 (8.23) 149,954
ALDER BIOPHARMACEUTICALS INC COM 45,518 37,582 473.58 879,581
ALDEYRA THERAPEUTICS INC COM 1,207 1,207 New 142,000
ALEXION PHARMACEUTICALS INC COM 1,421,328 121,893 9.38 7,673,730
ALNYLAM PHARMACEUTICALS INC COM 1,336 -31 (2.24) 11,340
AMICUS THERAPEUTICS INC COM -6,623 Sold Out 0
ANACOR PHARMACEUTICALS INC COM 330,448 New 4,204,702
AQUINOX PHARMACEUTICALS INC COM 8,326 -159 (1.87) 1,187,666
ARRAY BIOPHARMA INC COM 38,989 29,110 294.67 5,658,755
ASSEMBLY BIOSCIENCES INC COM 4,738 4,738 New 250,000
AURINIA PHARMACEUTICALS INC COM 2,284 -52 (2.22) 711,499