BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 10,857

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.16%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.09%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) ▲ Shares Held
AMICUS THERAPEUTICS INC COM -6,623 Sold Out 0
ASTERIAS BIOTHERAPEUTICS INC COM SER A -73 Sold Out 0
CELSUS THERAPEUTICS PLC SPONSORED ADR NE -418 Sold Out 0
GERON CORP COM -1,671 Sold Out 0
MALLINCKRODT PUB LTD CO SHS -5,575 Sold Out 0
QLT INC COM -6,589 Sold Out 0
SYNERGY PHARMACEUTICALS DEL COM NEW -9,032 Sold Out 0
TESARO INC COM -1,740 Sold Out 0
APTOSE BIOSCIENCES INC COM NEW 167 -2,229 (93.03) 33,397
TEKMIRA PHARMACEUTICALS CORP COM NEW 2,100 -3,531 (62.7) 180,582
VANDA PHARMACEUTICALS INC COM 22,105 -34,378 (60.86) 1,750,230
IRONWOOD PHARMACEUTICALS INC COM CL A 2,040 -2,135 (51.13) 169,163
ACHILLION PHARMACEUTICALS INC COM 1,838 -1,923 (51.13) 214,237
ISIS PHARMACEUTICALS INC COM 3,207 -2,198 (40.67) 57,140
CHIMERIX INC COM 5,309 -2,636 (33.18) 115,216
RIGEL PHARMACEUTICALS INC COM NEW 1,089 -381 (25.89) 357,187
BIOTA PHARMACEUTIALS INC COM 1,813 -512 (22.02) 863,184
HALOZYME THERAPEUTICS INC COM 49,684 -11,669 (19.02) 2,248,152
XOMA CORP DEL COM 54,790 -8,252 (13.09) 14,708,613
AGIOS PHARMACEUTICALS INC COM 16,561 -1,484 (8.23) 149,954