BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2015

Position Statistics

Total Positions 124
New Positions 8
Increased Positions 32
Decreased Positions 28
Positions with Activity 60
Sold Out Positions 9
Total Mkt Value (in $ millions) 9,262

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.2%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.03%
Services
Technology
Transportation
Utilities

124 Positions as of 06/30/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) ▲ Shares Held
AEGERION PHARMACEUTICALS INC COM -253 Sold Out 0
BIODEL INC COM NEW -19 Sold Out 0
CELLADON CORP COM -411 Sold Out 0
INFINITY PHARMACEUTICALS INC COM -2,831 Sold Out 0
LIPOCINE INC NEW COM -6,770 Sold Out 0
ORASURE TECHNOLOGIES INC COM -1,232 Sold Out 0
RIGEL PHARMACEUTICALS INC COM NEW -1,068 Sold Out 0
SYNTA PHARMACEUTICALS CORP COM -1,007 Sold Out 0
TRANSITION THERAPEUTICS INC COM NEW -1,669 Sold Out 0
FOUNDATION MEDICINE INC COM 497 -2,460 (83.19) 20,892
VANDA PHARMACEUTICALS INC COM 4,890 -15,990 (76.58) 409,881
AGIOS PHARMACEUTICALS INC COM 9,069 -4,530 (33.31) 100,000
ARROWHEAD RESH CORP COM NEW 5,825 -1,620 (21.76) 1,009,509
JUNO THERAPEUTICS INC COM 3,038 -760 (20) 80,000
BIODELIVERY SCIENCES INTL INC COM 1,443 -315 (17.92) 210,021
ULTRAGENYX PHARMACEUTICAL INC COM 14,053 -2,836 (16.79) 123,894
ALEXION PHARMACEUTICALS INC COM 1,170,209 -202,314 (14.74) 6,542,599
HALOZYME THERAPEUTICS INC COM 35,551 -5,838 (14.11) 1,931,057
ANACOR PHARMACEUTICALS INC COM 491,074 -78,453 (13.78) 3,625,498
SPARK THERAPEUTICS INC COM 57,590 -2,968 (4.9) 1,262,382