BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 9,957

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.17%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.67%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) ▲ Change (%) Shares Held
VANDA PHARMACEUTICALS INC COM 19,498 -30,322 (60.86) 1,750,230
HALOZYME THERAPEUTICS INC COM 52,674 -12,371 (19.02) 2,248,152
ABBVIE INC COM 1,064,457 -10,548 (0.98) 15,041,077
SYNERGY PHARMACEUTICALS DEL COM NEW -7,990 Sold Out 0
AMICUS THERAPEUTICS INC COM -7,982 Sold Out 0
QLT INC COM -5,898 Sold Out 0
MALLINCKRODT PUB LTD CO SHS -5,727 Sold Out 0
BIOCRYST PHARMACEUTICALS COM 159,897 -3,593 (2.2) 10,478,204
DYAX CORP COM 146,081 -3,307 (2.21) 6,021,485
TEKMIRA PHARMACEUTICALS CORP COM NEW 1,860 -3,127 (62.7) 180,582
CHIMERIX INC COM 6,071 -3,014 (33.18) 115,216
XENOPORT INC COM 46,341 -2,812 (5.72) 6,508,622
ISIS PHARMACEUTICALS INC COM 3,031 -2,078 (40.67) 57,140
APTOSE BIOSCIENCES INC COM NEW 145 -1,932 (93.03) 33,397
ACHILLION PHARMACEUTICALS INC COM 1,802 -1,885 (51.13) 214,237
BELLICUM PHARMACEUTICALS INC COM 83,267 -1,851 (2.17) 4,190,594
TESARO INC COM -1,849 Sold Out 0
IRONWOOD PHARMACEUTICALS INC COM CL A 1,759 -1,841 (51.13) 169,163
XOMA CORP DEL COM 12,208 -1,839 (13.09) 14,708,613
GERON CORP COM -1,647 Sold Out 0


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