BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 10,909

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.16%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.12%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) ▲ Change (%) Shares Held
VANDA PHARMACEUTICALS INC COM 22,000 -34,215 (60.86) 1,750,230
ABBVIE INC COM 2,540,029 -25,171 (0.98) 36,049,228
HALOZYME THERAPEUTICS INC COM 47,526 -11,162 (19.02) 2,248,152
XOMA CORP DEL COM 57,658 -8,684 (13.09) 14,708,613
SYNERGY PHARMACEUTICALS DEL COM NEW -8,000 Sold Out 0
AMICUS THERAPEUTICS INC COM -6,768 Sold Out 0
QLT INC COM -6,497 Sold Out 0
MALLINCKRODT PUB LTD CO SHS -5,450 Sold Out 0
TEKMIRA PHARMACEUTICALS CORP COM NEW 2,255 -3,792 (62.7) 180,582
DYAX CORP COM 156,679 -3,547 (2.21) 6,021,485
BIOCRYST PHARMACEUTICALS COM 153,191 -3,443 (2.2) 10,478,204
CHIMERIX INC COM 5,331 -2,647 (33.18) 115,216
APTOSE BIOSCIENCES INC COM NEW 181 -2,421 (93.03) 33,397
XENOPORT INC COM 39,768 -2,413 (5.72) 6,508,622
ISIS PHARMACEUTICALS INC COM 3,365 -2,306 (40.67) 57,140
IRONWOOD PHARMACEUTICALS INC COM CL A 2,034 -2,128 (51.13) 169,163
BELLICUM PHARMACEUTICALS INC COM 89,637 -1,992 (2.17) 4,190,594
ACHILLION PHARMACEUTICALS INC COM 1,862 -1,947 (51.13) 214,237
TESARO INC COM -1,806 Sold Out 0
GERON CORP COM -1,635 Sold Out 0