BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,473

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.12%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.52%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
IGNYTA INC COM 4,283 New 571,000
INSMED INC COM PAR $.01 4,235 -3,483 (45.12) 304,050
CELSUS THERAPEUTICS PLC SPONSORED ADR NE 3,976 New 673,887
ISIS PHARMACEUTICALS INC COM 3,925 New 96,303
STEMLINE THERAPEUTICS INC COM 3,820 New 338,671
LIGAND PHARMACEUTICALS INC COM NEW 3,820 New 73,400
CONCERT PHARMACEUTICALS INC COM 3,573 3,573 New 398,800
AMICUS THERAPEUTICS INC COM 3,463 New 481,697
KARYOPHARM THERAPEUTICS INC COM 3,387 1,260 59.23 94,095
ZOGENIX INC COM 3,173 New 2,350,400
ENANTA PHARMACEUTICALS INC COM 3,162 -235 (6.92) 75,357
ALDER BIOPHARMACEUTICALS INC COM 2,613 2,613 New 153,350
BIOTA PHARMACEUTIALS INC COM 2,546 New 1,106,910
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 2,309 New 221,631
SYNTA PHARMACEUTICALS CORP COM 2,000 New 500,000
ORASURE TECHNOLOGIES INC COM 1,955 New 234,664
GALECTIN THERAPEUTICS INC COM NEW 1,878 -1,252 (40) 300,000
MAST THERAPEUTICS INC COM 1,875 New 3,000,000
FOUNDATION MEDICINE INC COM 1,819 1,819 New 78,162
MEDIWOUND LTD ORD SHS 1,643 1,643 New 225,000