BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 103
New Positions 8
Increased Positions 29
Decreased Positions 18
Positions with Activity 47
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,699

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.89%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.52%
Services
Technology
Transportation
Utilities

103 Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
KARYOPHARM THERAPEUTICS INC COM 3,933 New 94,095
LIGAND PHARMACEUTICALS INC COM NEW 3,928 New 73,400
IGNYTA INC COM 3,586 New 571,000
CELSUS THERAPEUTICS PLC SPONSORED ADR NE 3,585 New 673,887
CYTRX CORP COM PAR $.001 3,456 New 1,350,000
AMICUS THERAPEUTICS INC COM 3,357 New 481,697
ENANTA PHARMACEUTICALS INC COM 3,316 New 75,357
BIODELIVERY SCIENCES INTL INC COM 3,037 -3,051 (50.11) 210,021
ZOGENIX INC COM 2,844 New 2,350,400
RECEPTOS INC COM 2,827 New 23,900
SYNERGY PHARMACEUTICALS DEL COM NEW 2,822 -2,277 (44.65) 973,245
SAGE THERAPEUTICS INC COM 2,782 2,782 New 75,000
LIPOCINE INC NEW COM 2,545 New 500,000
BIOTA PHARMACEUTIALS INC COM 2,468 New 1,106,910
AURINIA PHARMACEUTICALS INC COM 2,438 2,438 New 727,669
ALDER BIOPHARMACEUTICALS INC COM 2,355 New 153,350
AFFIMED N V COM 2,260 2,260 New 400,000
ORASURE TECHNOLOGIES INC COM 2,044 New 234,664
FOUNDATION MEDICINE INC COM 1,840 New 78,162
SYNTA PHARMACEUTICALS CORP COM 1,545 New 500,000