BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,716

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.92%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.62%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
JUNO THERAPEUTICS INC COM 5,657 New 100,000
SAGE THERAPEUTICS INC COM 5,536 New 75,000
CYTRX CORP COM PAR $.001 5,280 -120 (2.22) 1,319,989
AMARIN CORP PLC SPONS ADR NEW 5,073 5,073 New 2,205,710
CHIMERIX INC COM 4,794 -2,380 (33.18) 115,216
ASSEMBLY BIOSCIENCES INC COM 4,533 4,533 New 250,000
STEMLINE THERAPEUTICS INC COM 4,496 -70 (1.53) 333,497
AFFIMED N V COM 4,468 New 400,000
FOUNDATION MEDICINE INC COM 4,406 -67 (1.5) 124,255
EPIZYME INC COM 4,368 573 15.11 232,481
ZOGENIX INC COM 3,953 -89 (2.21) 2,298,466
RECEPTOS INC COM 3,823 New 23,900
ISIS PHARMACEUTICALS INC COM 3,788 -2,597 (40.67) 57,140
NEURODERM LTD ORD SHS 3,770 New 250,000
INFINITY PHARMACEUTICALS INC COM 3,728 -85 (2.24) 305,037
AERIE PHARMACEUTICALS INC COM 3,691 New 299,356
LIPOCINE INC NEW COM 3,527 -78 (2.17) 489,175
BELLEROPHON THERAPEUTICS INC COM 3,269 3,269 New 350,000
ZAFGEN INC COM 3,110 3,110 New 94,745
ENANTA PHARMACEUTICALS INC COM 3,058 New 75,357