BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2013

Position Statistics

Total Positions 88
New Positions 14
Increased Positions 31
Decreased Positions 21
Positions with Activity 52
Sold Out Positions 4
Total Mkt Value (in $ millions) 5,021

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.33%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.78%
Services
Technology
Transportation
Utilities

88 Positions as of 12/31/2013

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
RECEPTOS INC COM 3,599 New 100,000
OPHTHOTECH CORP COM 3,274 3,274 New 103,040
BLUEBIRD BIO INC COM 2,278 59 2.64 114,461
MACROGENICS INC COM 2,002 2,002 New 100,000
SYNTA PHARMACEUTICALS CORP COM 1,985 New 500,000
UNITED THERAPEUTICS CORP DEL COM 1,924 -3,462 (64.28) 20,000
KARYOPHARM THERAPEUTICS INC COM 1,907 1,907 New 61,330
PUMA BIOTECHNOLOGY INC COM 1,834 -5,503 (75) 25,000
ORASURE TECHNOLOGIES INC COM 1,685 New 243,467
RIGEL PHARMACEUTICALS INC COM NEW 1,600 New 500,000
VENTRUS BIOSCIENCES INC COM 1,313 New 1,215,840
ACHILLION PHARMACEUTICALS INC COM 1,288 New 455,000
GALECTIN THERAPEUTICS INC COM NEW 1,168 1,168 New 100,600
ACCELERON PHARMA INC COM 1,152 1,152 New 30,000
AMICUS THERAPEUTICS INC COM 948 New 515,072
ZIOPHARM ONCOLOGY INC COM 857 New 254,199
TESARO INC COM 782 New 31,218
GERON CORP COM 781 -1,159 (59.74) 402,629
FOUNDATION MEDICINE INC COM 531 531 New 20,000
CONTRAVIR PHARMACEUTICALS INC COM 514 New 257,176