BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 102
New Positions 8
Increased Positions 28
Decreased Positions 18
Positions with Activity 46
Sold Out Positions 6
Total Mkt Value (in $ millions) 7,624

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.97%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.18%
Services
Technology
Transportation
Utilities

102 Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
AERIE PHARMACEUTICALS INC COM 8,990 New 299,356
FOAMIX PHARMACEUTICALS LTD SHS 8,888 8,888 New 1,021,600
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 8,850 4,198 90.24 421,631
ULTRAGENYX PHARMACEUTICAL INC COM 8,732 2,911 50 150,000
OSIRIS THERAPEUTICS INC NEW COM 8,629 New 510,606
ARROWHEAD RESH CORP COM NEW 8,333 -1,354 (13.98) 1,230,802
PROQR THRAPEUTICS N V SHS EURO 8,288 8,288 New 400,000
THRESHOLD PHARMACEUTICAL INC COM NEW 7,985 1,228 18.17 2,158,141
IDERA PHARMACEUTICALS INC COM NEW 7,562 29 .38 1,619,258
ISIS PHARMACEUTICALS INC COM 7,020 New 96,303
ACHILLION PHARMACEUTICALS INC COM 6,836 New 438,337
QLT INC COM 6,804 New 1,535,863
CELLADON CORP COM 6,664 6,664 New 375,000
CONCERT PHARMACEUTICALS INC COM 5,964 696 13.21 451,496
IRONWOOD PHARMACEUTICALS INC COM CL A 5,767 -1,666 (22.41) 346,160
DISCOVERY LABORATORIES INC NEW COM NEW 5,259 New 3,652,117
INFINITY PHARMACEUTICALS INC COM 4,930 -4,930 (50) 312,025
STEMLINE THERAPEUTICS INC COM 4,579 New 338,671
EPIZYME INC COM 4,428 New 214,012
ALDER BIOPHARMACEUTICALS INC COM 4,329 New 153,350


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