BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 10,960

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.17%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.97%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ULTRAGENYX PHARMACEUTICAL INC COM 15,291 -114 (0.74) 148,894
REPROS THERAPEUTICS INC COM NEW 14,440 New 2,000,000
IMMUNOGEN INC COM 14,393 14,393 New 999,496
SANGAMO BIOSCIENCES INC COM 14,116 4,515 47.02 1,404,544
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 12,130 -283 (2.28) 412,008
LION BIOTECHNOLOGIES INC COM 11,965 11,965 New 1,325,000
THRESHOLD PHARMACEUTICAL INC COM NEW 11,790 3,103 35.72 2,925,519
ALCOBRA LTD SHS 11,294 9,465 517.47 1,789,871
MACROGENICS INC COM 11,232 -252 (2.2) 305,043
OMEROS CORP COM 11,149 -186 (1.64) 637,446
SUNESIS PHARMACEUTICALS INC COM NEW 10,496 New 3,200,000
OSIRIS THERAPEUTICS INC NEW COM 9,744 -223 (2.24) 499,193
ARROWHEAD RESH CORP COM NEW 8,876 409 4.83 1,290,187
IGNYTA INC COM 8,594 New 571,000
AQUINOX PHARMACEUTICALS INC COM 8,314 -159 (1.87) 1,187,666
CONCERT PHARMACEUTICALS INC COM 7,696 -148 (1.88) 495,908
LIGAND PHARMACEUTICALS INC COM NEW 7,260 -1 (0.02) 73,386
PROQR THRAPEUTICS N V SHS EURO 6,364 New 400,000
AFFIMED N V COM 5,796 New 400,000
KARYOPHARM THERAPEUTICS INC COM 5,611 3,178 130.61 216,990