BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 103
New Positions 8
Increased Positions 29
Decreased Positions 18
Positions with Activity 47
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,856

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.97%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.09%
Services
Technology
Transportation
Utilities

103 Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ARROWHEAD RESH CORP COM NEW 7,816 -1,270 (13.98) 1,230,802
OSIRIS THERAPEUTICS INC NEW COM 7,593 New 510,606
NOVAVAX INC COM 7,108 New 1,223,362
CELLADON CORP COM 6,953 6,953 New 375,000
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 6,894 3,270 90.24 421,631
ULTRAGENYX PHARMACEUTICAL INC COM 6,776 2,259 50 150,000
TEKMIRA PHARMACEUTICALS CORP COM NEW 6,764 New 484,156
ARRAY BIOPHARMA INC COM 6,653 New 1,433,797
FOAMIX PHARMACEUTICALS LTD SHS 6,487 6,487 New 1,021,600
THRESHOLD PHARMACEUTICAL INC COM NEW 6,323 972 18.17 2,158,141
IDERA PHARMACEUTICALS INC COM NEW 6,299 24 .38 1,619,258
ISIS PHARMACEUTICALS INC COM 5,729 New 96,303
ACHILLION PHARMACEUTICALS INC COM 5,725 New 438,337
QLT INC COM 5,713 New 1,535,863
CONCERT PHARMACEUTICALS INC COM 5,310 620 13.21 451,496
STEMLINE THERAPEUTICS INC COM 5,260 New 338,671
INFINITY PHARMACEUTICALS INC COM 5,195 -5,195 (50) 312,025
IRONWOOD PHARMACEUTICALS INC COM CL A 5,044 -1,457 (22.41) 346,160
DISCOVERY LABORATORIES INC NEW COM NEW 4,273 New 3,652,117
ALDER BIOPHARMACEUTICALS INC COM 3,936 New 153,350


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