BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 27
Decreased Positions 15
Positions with Activity 42
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,184

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.02%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.44%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
AERIE PHARMACEUTICALS INC COM 7,011 New 299,356
BIODELIVERY SCIENCES INTL INC COM 6,997 New 421,005
OSIRIS THERAPEUTICS INC NEW COM 6,914 2,018 41.24 510,606
EPIZYME INC COM 6,356 New 214,012
NOVAVAX INC COM 6,276 New 1,223,362
QLT INC COM 6,174 New 1,535,863
MACROGENICS INC COM 5,976 4,133 224.33 311,891
SANGAMO BIOSCIENCES INC COM 5,933 New 522,764
IRONWOOD PHARMACEUTICALS INC COM CL A 5,916 New 446,160
CATALYST PHARM PARTNERS INC COM 5,735 4,265 290.11 2,223,053
XENCOR INC COM 5,695 New 542,363
THRESHOLD PHARMACEUTICAL INC COM NEW 5,497 New 1,826,358
CONCERT PHARMACEUTICALS INC COM 5,495 5,495 New 398,800
ARRAY BIOPHARMA INC COM 5,162 New 1,433,797
ACHILLION PHARMACEUTICALS INC COM 5,133 New 438,337
ULTRAGENYX PHARMACEUTICAL INC COM 5,022 New 100,000
SYNERGY PHARMACEUTICALS DEL COM NEW 4,941 New 1,758,271
STEMLINE THERAPEUTICS INC COM 4,796 New 338,671
INSMED INC COM PAR $.01 4,339 -3,568 (45.12) 304,050
ISIS PHARMACEUTICALS INC COM 4,334 New 96,303


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