BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 109
New Positions 14
Increased Positions 27
Decreased Positions 13
Positions with Activity 40
Sold Out Positions 1
Total Mkt Value (in $ millions) 9,549

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.05%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 94.98%
Services
Technology
Transportation
Utilities

109 Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 9,676 New 421,631
AQUINOX PHARMACEUTICALS INC COM 9,404 -12 (0.12) 1,210,350
TEKMIRA PHARMACEUTICALS CORP COM NEW 9,078 New 484,156
ARROWHEAD RESH CORP COM NEW 8,960 New 1,230,802
THRESHOLD PHARMACEUTICAL INC COM NEW 8,838 -11 (0.12) 2,155,516
XENCOR INC COM 8,711 722 9.04 591,371
SUNESIS PHARMACEUTICALS INC COM NEW 8,608 8,608 New 3,200,000
OSIRIS THERAPEUTICS INC NEW COM 8,338 New 510,606
PROQR THRAPEUTICS N V SHS EURO 7,784 New 400,000
CONCERT PHARMACEUTICALS INC COM 7,420 792 11.94 505,418
CYTRX CORP COM PAR $.001 6,926 New 1,350,000
CHIMERIX INC COM 6,807 6,807 New 172,414
LIGAND PHARMACEUTICALS INC COM NEW 6,588 New 73,400
ISIS PHARMACEUTICALS INC COM 6,392 New 96,303
AMICUS THERAPEUTICS INC COM 5,901 New 481,697
FOUNDATION MEDICINE INC COM 5,875 2,235 61.39 126,147
MALLINCKRODT PUB LTD CO SHS 5,694 -18,935 (76.88) 46,666
QLT INC COM 5,683 New 1,535,863
JUNO THERAPEUTICS INC COM 5,666 5,666 New 100,000
STEMLINE THERAPEUTICS INC COM 5,615 New 338,671