BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,473

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.12%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.52%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ACORDA THERAPEUTICS INC COM 29,520 -3,060 (9.39) 906,091
VERSARTIS INC COM 28,655 28,655 New 1,245,889
GILEAD SCIENCES INC COM 27,547 -32,268 (53.95) 256,108
HALOZYME THERAPEUTICS INC COM 26,373 -27,759 (51.28) 2,776,143
PROGENICS PHARMACEUTICALS INC COM 24,518 New 4,449,797
HERON THERAPEUTICS INC COM 24,487 4,132 20.30 2,607,784
SALIX PHARMACEUTICALS INC COM 21,276 20,700 3,592.93 133,721
ARROWHEAD RESH CORP COM NEW 20,847 10,181 95.45 1,430,802
XENOPORT INC COM 20,493 New 4,034,112
TG THERAPEUTICS INC COM 18,325 New 2,160,965
AEGERION PHARMACEUTICALS INC COM 12,645 -3,055 (19.46) 413,922
KYTHERA BIOPHARMACEUTICALS INC COM 11,706 New 311,255
OMEROS CORP COM 11,239 New 753,804
TEKMIRA PHARMACEUTICALS CORP COM NEW 10,361 New 484,156
AQUINOX PHARMACEUTICALS INC COM 9,949 New 1,211,851
AGIOS PHARMACEUTICALS INC COM 9,239 New 199,893
NEUROCRINE BIOSCIENCES INC COM 9,045 1,741 23.83 554,590
QLT INC COM 8,432 New 1,535,863
BLUEBIRD BIO INC COM 7,932 New 198,260
THRESHOLD PHARMACEUTICAL INC COM NEW 7,598 New 1,826,358