BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 109
New Positions 14
Increased Positions 27
Decreased Positions 13
Positions with Activity 40
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,911

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.06%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 95.15%
Services
Technology
Transportation
Utilities

109 Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
HERON THERAPEUTICS INC COM 28,712 New 2,607,784
DERMA SCIENCES INC COM PAR $.01 28,120 New 3,537,137
GILEAD SCIENCES INC COM 26,894 New 256,108
INSMED INC COM PAR $.01 23,486 New 1,107,850
PROGENICS PHARMACEUTICALS INC COM 23,317 New 4,449,797
ACORDA THERAPEUTICS INC COM 22,492 64 .28 755,534
CATALYST PHARM PARTNERS INC COM 22,362 New 6,715,462
BLUEBIRD BIO INC COM 20,841 New 150,000
NEUROCRINE BIOSCIENCES INC COM 19,693 New 554,590
CLOVIS ONCOLOGY INC COM 16,634 16,634 New 202,630
AGIOS PHARMACEUTICALS INC COM 15,643 -622 (3.83) 163,393
REPROS THERAPEUTICS INC COM NEW 15,600 -6,074 (28.02) 2,000,000
OMEROS CORP COM 13,241 -3,283 (19.87) 648,101
KYTHERA BIOPHARMACEUTICALS INC COM 13,005 -1,136 (8.03) 286,255
SANGAMO BIOSCIENCES INC COM 12,238 1,159 10.46 955,332
FOAMIX PHARMACEUTICALS LTD SHS 10,696 New 1,021,600
NOVAVAX INC COM 9,726 New 1,223,362
MACROGENICS INC COM 9,279 New 311,891
ARRAY BIOPHARMA INC COM 9,062 New 1,433,797
ULTRAGENYX PHARMACEUTICAL INC COM 8,973 New 150,000