BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 27
Decreased Positions 15
Positions with Activity 42
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,396

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.99%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.51%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
XENOPORT INC COM 27,553 New 4,034,112
HALOZYME THERAPEUTICS INC COM 25,985 -27,350 (51.28) 2,776,143
TG THERAPEUTICS INC COM 24,441 New 2,160,965
VERSARTIS INC COM 24,282 24,282 New 1,245,889
PROGENICS PHARMACEUTICALS INC COM 21,448 New 4,449,797
HERON THERAPEUTICS INC COM 21,045 3,551 20.30 2,607,784
SALIX PHARMACEUTICALS INC COM 18,713 18,206 3,592.93 133,721
REPROS THERAPEUTICS INC COM NEW 18,033 New 2,778,654
AGIOS PHARMACEUTICALS INC COM 16,111 New 199,893
AEGERION PHARMACEUTICALS INC COM 13,945 -3,369 (19.46) 413,922
AMBIT BIOSCIENCES CORP COM 11,556 New 747,954
KYTHERA BIOPHARMACEUTICALS INC COM 11,454 New 311,255
NEUROCRINE BIOSCIENCES INC COM 10,260 1,974 23.83 554,590
ARROWHEAD RESH CORP COM NEW 9,830 4,800 95.45 1,430,802
OMEROS CORP COM 9,008 New 753,804
TEKMIRA PHARMACEUTICALS CORP COM NEW 8,875 New 484,156
AQUINOX PHARMACEUTICALS INC COM 8,616 New 1,211,851
INFINITY PHARMACEUTICALS INC COM 8,525 New 624,050
BLUEBIRD BIO INC COM 8,133 New 198,260
BIODELIVERY SCIENCES INTL INC COM 7,229 New 421,005