BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 9,957

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.17%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.67%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
INSMED INC COM PAR $.01 42,533 12,776 42.93 1,583,490
ALDER BIOPHARMACEUTICALS INC COM 40,452 33,399 473.58 879,581
CATALYST PHARMACEUTICALS INC COM 37,222 4,182 12.66 7,565,462
PROGENICS PHARMACEUTICALS INC COM 36,677 -834 (2.23) 4,350,808
TG THERAPEUTICS INC COM 35,081 New 2,050,313
ARRAY BIOPHARMA INC COM 32,594 24,336 294.67 5,658,755
GILEAD SCIENCES INC COM 28,927 -707 (2.39) 249,995
NEUROCRINE BIOSCIENCES INC COM 27,470 -626 (2.23) 542,236
KYTHERA BIOPHARMACEUTICALS INC COM 26,357 5,060 23.76 354,265
ACORDA THERAPEUTICS INC COM 24,961 -561 (2.2) 738,916
DERMA SCIENCES INC COM PAR $.01 24,032 -551 (2.24) 3,457,841
IDERA PHARMACEUTICALS INC COM NEW 23,961 18,360 327.81 6,965,432
BLUEBIRD BIO INC COM 23,309 -544 (2.28) 146,581
NOVAVAX INC COM 23,232 8,625 59.04 1,945,687
XENCOR INC COM 19,752 6,358 47.47 872,072
VANDA PHARMACEUTICALS INC COM 19,498 -30,322 (60.86) 1,750,230
FOAMIX PHARMACEUTICALS LTD SHS 19,240 8,452 78.34 1,821,967
IMMUNOGEN INC COM 17,851 17,851 New 999,496
ULTRAGENYX PHARMACEUTICAL INC COM 17,337 -129 (0.74) 148,894
CLOVIS ONCOLOGY INC COM 17,333 New 202,630