BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 100
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,443

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.07%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.61%
Services
Technology
Transportation
Utilities

17 New Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ACORDA THERAPEUTICS INC COM 31,310 31,310 New 1,000,000
HERON THERAPEUTICS INC COM 22,285 22,285 New 2,167,784
AQUINOX PHARMACEUTICALS INC COM 10,773 10,773 New 1,211,851
NEUROCRINE BIOSCIENCES INC COM 6,342 6,342 New 447,874
IGNYTA INC COM 5,139 5,139 New 571,000
CYTRX CORP COM PAR $.001 4,752 4,752 New 1,350,000
CELSUS THERAPEUTICS PLC SPONSORED ADR NE 4,117 4,117 New 673,887
ULTRAGENYX PHARMACEUTICAL INC COM 4,037 4,037 New 100,000
RETROPHIN INC COM 2,155 2,155 New 197,178
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 1,984 1,984 New 221,631
MAST THERAPEUTICS INC COM 1,824 1,824 New 3,000,000
CATALYST PHARM PARTNERS INC COM 1,288 1,288 New 569,853
ACHAOGEN INC COM 1,225 1,225 New 100,000
AUXILIUM PHARMACEUTICALS INC COM 1,129 1,129 New 58,544
REGADO BIOSCIENCES INC COM 1,004 1,004 New 400,000
ALNYLAM PHARMACEUTICALS INC COM 671 671 New 11,600
UNIQURE NV SHS 399 399 New 30,672