BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 9,989

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.2%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.61%
Services
Technology
Transportation
Utilities

17 New Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SPARK THERAPEUTICS INC COM 81,559 81,559 New 1,327,451
INVITAE CORP COM 65,484 65,484 New 6,554,967
IMMUNOGEN INC COM 18,011 18,011 New 999,496
LION BIOTECHNOLOGIES INC COM 11,342 11,342 New 1,325,000
AMARIN CORP PLC SPONS ADR NEW 4,985 4,985 New 2,205,710
ASSEMBLY BIOSCIENCES INC COM 3,750 3,750 New 250,000
ZAFGEN INC COM 3,597 3,597 New 94,745
INTRA CELLULAR THERAPIES INC COM 3,031 3,031 New 104,166
ASCENDIS PHARMA A S SPONSORED ADR 2,003 2,003 New 100,000
VITAE PHARMACEUTICALS INC COM 1,897 1,897 New 187,597
CELLECTIS S A SPONSORED ADS 1,787 1,787 New 50,000
TRANSITION THERAPEUTICS INC COM NEW 1,685 1,685 New 769,230
ALDEYRA THERAPEUTICS INC COM 1,262 1,262 New 142,000
BELLEROPHON THERAPEUTICS INC COM 1,215 1,215 New 350,000
OHR PHARMACEUTICAL INC COM NEW 1,137 1,137 New 370,370
AEGERION PHARMACEUTICALS INC COM 274 274 New 14,300
BIODEL INC COM NEW 30 30 New 30,179