BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 110
New Positions 14
Increased Positions 28
Decreased Positions 13
Positions with Activity 41
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,544

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.02%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 94.87%
Services
Technology
Transportation
Utilities

14 New Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BELLICUM PHARMACEUTICALS INC COM 99,468 99,468 New 4,283,732
DBV TECHNOLOGIES S A SPONSORED ADR 32,922 32,922 New 1,519,229
CLOVIS ONCOLOGY INC COM 15,493 15,493 New 202,630
SUNESIS PHARMACEUTICALS INC COM NEW 7,104 7,104 New 3,200,000
CHIMERIX INC COM 6,979 6,979 New 172,414
JUNO THERAPEUTICS INC COM 4,692 4,692 New 100,000
NEURODERM LTD ORD SHS 3,458 3,458 New 250,000
APTOSE BIOSCIENCES INC COM NEW 2,381 2,381 New 479,164
ALCOBRA LTD SHS 2,183 2,183 New 289,871
PALATIN TECHNOLOGIES INC COM PAR $ .01 1,933 1,933 New 2,050,000
PROTEON THERAPEUTICS INC COM 1,869 1,869 New 172,917
DERMIRA INC COM 1,673 1,673 New 100,000
ASTERIAS BIOTHERAPEUTICS INC COM SER A 67 67 New 16,775
BIOTIME INC WT EXP 100118 27 27 New 20,525


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