BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 110
New Positions 14
Increased Positions 28
Decreased Positions 13
Positions with Activity 41
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,988

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.15%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 94.91%
Services
Technology
Transportation
Utilities

14 New Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BELLICUM PHARMACEUTICALS INC COM 99,254 99,254 New 4,283,732
DBV TECHNOLOGIES S A SPONSORED ADR 35,489 35,489 New 1,519,229
CLOVIS ONCOLOGY INC COM 15,041 15,041 New 202,630
SUNESIS PHARMACEUTICALS INC COM NEW 7,840 7,840 New 3,200,000
CHIMERIX INC COM 6,498 6,498 New 172,414
JUNO THERAPEUTICS INC COM 6,066 6,066 New 100,000
NEURODERM LTD ORD SHS 3,355 3,355 New 250,000
APTOSE BIOSCIENCES INC COM NEW 2,597 2,597 New 479,164
PALATIN TECHNOLOGIES INC COM PAR $ .01 2,091 2,091 New 2,050,000
PROTEON THERAPEUTICS INC COM 2,011 2,011 New 172,917
ALCOBRA LTD SHS 1,632 1,632 New 289,871
DERMIRA INC COM 1,535 1,535 New 100,000
ASTERIAS BIOTHERAPEUTICS INC COM SER A 113 113 New 16,775
BIOTIME INC WT EXP 100118 41 41 New 20,525


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