BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,716

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.92%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.62%
Services
Technology
Transportation
Utilities

17 New Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SPARK THERAPEUTICS INC COM 98,417 98,417 New 1,327,451
INVITAE CORP COM 85,477 85,477 New 6,554,967
LION BIOTECHNOLOGIES INC COM 14,204 14,204 New 1,325,000
IMMUNOGEN INC COM 14,023 14,023 New 999,496
TRANSITION THERAPEUTICS INC COM NEW 5,912 5,912 New 769,230
AMARIN CORP PLC SPONS ADR NEW 5,073 5,073 New 2,205,710
ASSEMBLY BIOSCIENCES INC COM 4,533 4,533 New 250,000
BELLEROPHON THERAPEUTICS INC COM 3,269 3,269 New 350,000
ZAFGEN INC COM 3,110 3,110 New 94,745
INTRA CELLULAR THERAPIES INC COM 2,789 2,789 New 104,166
VITAE PHARMACEUTICALS INC COM 2,266 2,266 New 187,597
CELLECTIS S A SPONSORED ADS 2,121 2,121 New 50,000
ASCENDIS PHARMA A S SPONSORED ADR 1,623 1,623 New 100,000
ALDEYRA THERAPEUTICS INC COM 1,079 1,079 New 142,000
OHR PHARMACEUTICAL INC COM NEW 1,011 1,011 New 370,370
AEGERION PHARMACEUTICALS INC COM 277 277 New 14,300
BIODEL INC COM NEW 33 33 New 30,179