BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,030

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.08%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.63%
Services
Technology
Transportation
Utilities

28 INCREASED Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,136,982 101,193 9.77 9,591,546
SEATTLE GENETICS INC COM 955,070 73,644 8.36 22,472,229
SYNAGEVA BIOPHARMA CORP COM 748,576 860 .12 10,660,432
INCYTE CORP COM 745,099 502 .07 14,845,559
GENOMIC HEALTH INC COM 383,430 21 .01 13,654,902
INTERMUNE INC COM 251,304 21,179 9.20 4,722,869
BIOCRYST PHARMACEUTICALS COM 137,334 63,351 85.63 10,890,872
BIOMARIN PHARMACEUTICAL INC COM 132,374 1,734 1.33 1,908,230
AVANIR PHARMACEUTICALS INC CL A NEW 105,041 72,269 220.52 18,558,487
XOMA CORP DEL COM 96,416 35 .04 23,065,972
ANACOR PHARMACEUTICALS INC COM 65,513 3,080 4.93 3,248,043
DYAX CORP COM 54,227 30,062 124.40 5,681,237
CERUS CORP COM 37,298 6,520 21.19 10,246,591
CLOVIS ONCOLOGY INC COM 33,268 11,040 49.67 793,221
VERSARTIS INC COM 24,669 24,669 New 1,245,889
HERON THERAPEUTICS INC COM 22,948 3,872 20.30 2,607,784
SALIX PHARMACEUTICALS INC COM 21,168 20,595 3,592.93 133,721
ARROWHEAD RESH CORP COM NEW 18,200 8,888 95.45 1,430,802
NEUROCRINE BIOSCIENCES INC COM 8,363 1,609 23.83 554,590
OSIRIS THERAPEUTICS INC NEW COM 7,220 2,108 41.24 510,606