BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2015

Position Statistics

Total Positions 127
New Positions 5
Increased Positions 30
Decreased Positions 12
Positions with Activity 42
Sold Out Positions 7
Total Mkt Value (in $ millions) 9,143

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.69%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.16%
Services
Technology
Transportation
Utilities

30 INCREASED Positions as of 12/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SHIRE PLC SPONSORED ADR 1,557,463 140,291 9.90 8,310,017
INCYTE CORP COM 1,407,481 25 .00 19,475,316
SEATTLE GENETICS INC COM 1,323,181 44,846 3.51 37,293,728
GENOMIC HEALTH INC COM 358,965 25 .01 13,659,264
BIOMARIN PHARMACEUTICAL INC COM 348,465 3,280 .95 4,115,083
ANACOR PHARMACEUTICALS INC COM 263,415 3,959 1.53 4,198,520
ACORDA THERAPEUTICS INC COM 92,546 64,192 226.39 3,580,112
BELLICUM PHARMACEUTICALS INC COM 49,338 6,845 16.11 4,865,647
BIOCRYST PHARMACEUTICALS COM 46,350 351 .76 14,217,779
NEUROCRINE BIOSCIENCES INC COM 38,777 4,558 13.32 850,739
IMMUNOGEN INC COM 30,499 6,195 25.49 4,452,445
SANGAMO BIOSCIENCES INC COM 25,552 1,890 7.99 4,055,876
ADVANCED ACCELERATOR APPLIC SPONSORED ADS 19,702 19,702 New 567,454
DERMA SCIENCES INC COM PAR $.01 13,058 1,025 8.52 3,752,390
IDERA PHARMACEUTICALS INC COM NEW 11,592 12 .10 6,983,107
ALKERMES PLC SHS 9,947 9,947 New 250,251
ALCOBRA LTD SHS 9,369 2,793 42.47 2,336,359
DIMENSION THERAPEUTICS INC COM 8,777 8,777 New 1,234,481
ASCENDIS PHARMA A S SPONSORED ADR 8,528 1,181 16.07 505,521
GLOBAL BLOOD THERAPEUTICS INC COM 8,068 4,034 100 400,000