BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 109
New Positions 14
Increased Positions 27
Decreased Positions 13
Positions with Activity 40
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,911

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.06%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 95.15%
Services
Technology
Transportation
Utilities

27 INCREASED Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SEATTLE GENETICS INC COM 948,134 183,285 23.96 27,861,720
BIOMARIN PHARMACEUTICAL INC COM 430,521 155,737 56.68 3,713,950
GENOMIC HEALTH INC COM 386,201 20 .01 13,656,318
BELLICUM PHARMACEUTICALS INC COM 98,869 98,869 New 4,283,732
VANDA PHARMACEUTICALS INC COM 42,307 946 2.29 4,472,153
XENOPORT INC COM 41,974 534 1.29 6,903,628
VERSARTIS INC COM 39,908 18,114 83.11 2,281,744
DBV TECHNOLOGIES S A SPONSORED ADR 38,376 38,376 New 1,519,229
ACORDA THERAPEUTICS INC COM 22,492 64 .28 755,534
CLOVIS ONCOLOGY INC COM 16,634 16,634 New 202,630
SANGAMO BIOSCIENCES INC COM 12,238 1,159 10.46 955,332
XENCOR INC COM 8,640 716 9.04 591,371
CONCERT PHARMACEUTICALS INC COM 7,495 800 11.94 505,418
SUNESIS PHARMACEUTICALS INC COM NEW 7,232 7,232 New 3,200,000
CHIMERIX INC COM 6,093 6,093 New 172,414
FOUNDATION MEDICINE INC COM 5,743 2,185 61.39 126,147
IDERA PHARMACEUTICALS INC COM NEW 4,738 26 .55 1,628,172
JUNO THERAPEUTICS INC COM 4,482 4,482 New 100,000
NEURODERM LTD ORD SHS 3,020 3,020 New 250,000
APTOSE BIOSCIENCES INC COM NEW 2,669 2,669 New 479,164