BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2015

Position Statistics

Total Positions 124
New Positions 8
Increased Positions 32
Decreased Positions 28
Positions with Activity 60
Sold Out Positions 9
Total Mkt Value (in $ millions) 8,984

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.21%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92%
Services
Technology
Transportation
Utilities

32 INCREASED Positions as of 06/30/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
INCYTE CORP COM 1,727,229 2,324 .14 14,865,559
SEATTLE GENETICS INC COM 1,243,145 80,280 6.90 30,870,262
GENOMIC HEALTH INC COM 375,857 18 .01 13,657,598
DYAX CORP COM 182,471 43,856 31.64 7,926,630
BIOCRYST PHARMACEUTICALS COM 134,760 12,793 10.49 11,577,299
HERON THERAPEUTICS INC COM 107,987 7,692 7.67 2,807,784
DBV TECHNOLOGIES S A SPONSORED ADR 72,675 13,379 22.56 1,862,019
VERSARTIS INC COM 44,573 5,956 15.42 3,436,585
ALDER BIOPHARMACEUTICALS INC COM 34,553 469 1.38 891,688
ATYR PHARMA INC COM 33,813 33,813 New 2,335,125
IMMUNOGEN INC COM 31,233 17,780 132.16 2,320,424
KYTHERA BIOPHARMACEUTICALS INC COM 28,972 2,501 9.45 387,741
SANGAMO BIOSCIENCES INC COM 24,426 13,807 130.03 3,230,932
ZOGENIX INC COM NEW 24,094 18,572 336.32 1,253,571
GALAPAGOS NV SPON ADR 22,371 22,371 New 369,276
IDERA PHARMACEUTICALS INC COM NEW 21,052 17 .08 6,970,902
FOAMIX PHARMACEUTICALS LTD SHS 20,797 2,286 12.35 2,046,967
AQUINOX PHARMACEUTICALS INC COM 20,487 166 .82 1,197,366
BLUEBIRD BIO INC COM 20,108 602 3.09 151,105
PROQR THRAPEUTICS N V SHS EURO 17,216 10,248 147.08 988,299