BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,641

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.05%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.57%
Services
Technology
Transportation
Utilities

59 DECREASED Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 2,567,787 -25,446 (0.98) 36,049,228
BIOCRYST PHARMACEUTICALS COM 164,717 -3,702 (2.2) 10,478,204
DYAX CORP COM 150,959 -3,417 (2.21) 6,021,485
BELLICUM PHARMACEUTICALS INC COM 84,105 -1,869 (2.17) 4,190,594
HALOZYME THERAPEUTICS INC COM 53,304 -12,519 (19.02) 2,248,152
XENOPORT INC COM 47,448 -2,880 (5.72) 6,508,622
PROGENICS PHARMACEUTICALS INC COM 40,985 -932 (2.23) 4,350,808
GILEAD SCIENCES INC COM 28,267 -691 (2.39) 249,995
NEUROCRINE BIOSCIENCES INC COM 28,153 -641 (2.23) 542,236
ACORDA THERAPEUTICS INC COM 25,574 -575 (2.2) 738,916
DERMA SCIENCES INC COM PAR $.01 24,205 -555 (2.24) 3,457,841
BLUEBIRD BIO INC COM 23,500 -548 (2.28) 146,581
VANDA PHARMACEUTICALS INC COM 19,498 -30,322 (60.86) 1,750,230
ULTRAGENYX PHARMACEUTICAL INC COM 17,957 -133 (0.74) 148,894
AGIOS PHARMACEUTICALS INC COM 16,777 -1,504 (8.23) 149,954
XOMA CORP DEL COM 12,885 -1,941 (13.09) 14,708,613
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 12,282 -287 (2.28) 412,008
MACROGENICS INC COM 11,387 -256 (2.2) 305,043
OSIRIS THERAPEUTICS INC NEW COM 10,733 -245 (2.24) 499,193
OMEROS CORP COM 10,429 -174 (1.64) 637,446