BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,106

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.07%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.64%
Services
Technology
Transportation
Utilities

15 DECREASED Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
VANDA PHARMACEUTICALS INC COM 54,696 -920 (1.65) 4,372,153
MALLINCKRODT PUB LTD CO SHS 32,714 -14,246 (30.34) 448,500
ACORDA THERAPEUTICS INC COM 28,542 -2,958 (9.39) 906,091
GILEAD SCIENCES INC COM 26,625 -31,188 (53.95) 256,108
HALOZYME THERAPEUTICS INC COM 26,318 -27,701 (51.28) 2,776,143
AEGERION PHARMACEUTICALS INC COM 12,476 -3,014 (19.46) 413,922
INSMED INC COM PAR $.01 3,998 -3,288 (45.12) 304,050
ENANTA PHARMACEUTICALS INC COM 2,980 -221 (6.92) 75,357
GALECTIN THERAPEUTICS INC COM NEW 1,566 -1,044 (40) 300,000
ASSEMBLY BIOSCIENCES INC COM -574 Sold Out 0
AUXILIUM PHARMACEUTICALS INC COM -1,081 Sold Out 0
INTERCEPT PHARMACEUTICALS INC COM -73,608 Sold Out 0
PORTOLA PHARMACEUTICALS INC COM -4,567 Sold Out 0
PROTHENA CORP PLC SHS -4,946 Sold Out 0
RETROPHIN INC COM -2,423 Sold Out 0