BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2015

Position Statistics

Total Positions 127
New Positions 5
Increased Positions 30
Decreased Positions 12
Positions with Activity 42
Sold Out Positions 7
Total Mkt Value (in $ millions) 9,143

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.69%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.16%
Services
Technology
Transportation
Utilities

12 DECREASED Positions as of 12/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
XENOPORT INC COM 15,293 -13,345 (46.6) 3,475,672
INSMED INC COM PAR $.01 12,150 -7,089 (36.85) 1,000,000
ZOGENIX INC COM NEW 10,250 -8,183 (44.39) 1,000,000
CYTRX CORP COM PAR $.001 2,152 -2,152 (50) 659,995
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 254 -7,372 (96.66) 13,746
ALDER BIOPHARMACEUTICALS INC COM -13,632 Sold Out 0
BELLEROPHON THERAPEUTICS INC COM -695 Sold Out 0
CLOVIS ONCOLOGY INC COM -2,819 Sold Out 0
REPROS THERAPEUTICS INC COM NEW -4,636 Sold Out 0
SYNERGY PHARMACEUTICALS DEL COM NEW -211 Sold Out 0
THRESHOLD PHARMACEUTICAL INC COM NEW -1,287 Sold Out 0
ZAFGEN INC COM -2,487 Sold Out 0