BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 103
New Positions 8
Increased Positions 29
Decreased Positions 18
Positions with Activity 47
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,749

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.98%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.06%
Services
Technology
Transportation
Utilities

18 DECREASED Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BIOCRYST PHARMACEUTICALS COM 118,601 -1,961 (1.63) 10,713,686
TG THERAPEUTICS INC COM 32,190 -1,737 (5.12) 2,050,313
ACORDA THERAPEUTICS INC COM 28,930 -5,864 (16.85) 753,391
MALLINCKRODT PUB LTD CO SHS 19,808 -24,203 (54.99) 201,856
AGIOS PHARMACEUTICALS INC COM 18,216 -3,217 (15.01) 169,893
BLUEBIRD BIO INC COM 12,830 -4,128 (24.34) 150,000
ARROWHEAD RESH CORP COM NEW 7,723 -1,255 (13.98) 1,230,802
INFINITY PHARMACEUTICALS INC COM 5,080 -5,080 (50) 312,025
IRONWOOD PHARMACEUTICALS INC COM CL A 4,957 -1,432 (22.41) 346,160
SYNERGY PHARMACEUTICALS DEL COM NEW 2,881 -2,324 (44.65) 973,245
BIODELIVERY SCIENCES INTL INC COM 2,518 -2,530 (50.11) 210,021
SALIX PHARMACEUTICALS INC COM 1,001 -14,524 (93.55) 8,621
AEGERION PHARMACEUTICALS INC COM -9,048 Sold Out 0
ASTERIAS BIOTHERAPEUTICS INC COM SER A -54 Sold Out 0
BIOTIME INC WT EXP 100118 -18 Sold Out 0
CLOVIS ONCOLOGY INC COM -42,953 Sold Out 0
GALECTIN THERAPEUTICS INC COM NEW -969 Sold Out 0
REGADO BIOSCIENCES INC COM -356 Sold Out 0