BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 100
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,443

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.07%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.61%
Services
Technology
Transportation
Utilities

51 DECREASED Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BIOMARIN PHARMACEUTICAL INC COM 111,224 -3,430 (2.99) 1,883,230
BIOCRYST PHARMACEUTICALS COM 69,231 -9,829 (12.43) 5,867,031
QUESTCOR PHARMACEUTICALS INC COM 67,102 -5,434 (7.49) 717,745
VANDA PHARMACEUTICALS INC COM 64,107 -4,982 (7.21) 4,445,696
INTERCEPT PHARMACEUTICALS INC COM 57,274 -23,786 (29.34) 256,375
HALOZYME THERAPEUTICS INC COM 52,936 -5,564 (9.51) 5,698,139
TG THERAPEUTICS INC COM 21,545 -386 (1.76) 2,160,965
CLOVIS ONCOLOGY INC COM 20,368 -29 (0.14) 529,990
KYTHERA BIOPHARMACEUTICALS INC COM 10,779 -67 (0.62) 311,255
INSMED INC COM PAR $.01 10,433 -4,563 (30.43) 554,050
ARROWHEAD RESH CORP COM NEW 8,946 -28,814 (76.31) 732,062
AGIOS PHARMACEUTICALS INC COM 7,654 -224 (2.85) 199,893
AERIE PHARMACEUTICALS INC COM 7,610 -16 (0.22) 299,356
THRESHOLD PHARMACEUTICAL INC COM NEW 7,525 -107 (1.41) 1,826,358
INFINITY PHARMACEUTICALS INC COM 7,108 -219 (2.99) 624,050
DISCOVERY LABORATORIES INC NEW COM NEW 7,049 -128 (1.79) 3,652,117
SYNERGY PHARMACEUTICALS DEL COM NEW 6,769 -3,273 (32.59) 1,758,271
EPIZYME INC COM 6,656 -186 (2.72) 214,012
IRONWOOD PHARMACEUTICALS INC COM CL A 6,429 -1,441 (18.31) 446,160
ARRAY BIOPHARMA INC COM 5,821 -269 (4.41) 1,433,797


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