BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 9,989

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.2%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.61%
Services
Technology
Transportation
Utilities

99 Activity Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ALEXION PHARMACEUTICALS INC COM 1,515,101 129,935 9.38 7,673,730
SEATTLE GENETICS INC COM 1,382,328 48,588 3.64 28,876,712
ABBVIE INC COM 1,053,026 -10,435 (0.98) 15,041,077
BIOMARIN PHARMACEUTICAL INC COM 614,401 71,161 13.10 4,200,456
GENOMIC HEALTH INC COM 369,830 17 .01 13,656,942
BIOCRYST PHARMACEUTICALS COM 162,203 -3,645 (2.2) 10,478,204
DYAX CORP COM 148,189 -3,354 (2.21) 6,021,485
BELLICUM PHARMACEUTICALS INC COM 85,279 -1,895 (2.17) 4,190,594
SPARK THERAPEUTICS INC COM 81,559 81,559 New 1,327,451
MIRATI THERAPEUTICS INC COM 80,253 12,159 17.86 2,805,074
CERUS CORP COM 73,594 10,048 15.81 13,553,275
INVITAE CORP COM 65,484 65,484 New 6,554,967
VERSARTIS INC COM 53,891 12,591 30.49 2,977,396
HALOZYME THERAPEUTICS INC COM 52,472 -12,323 (19.02) 2,248,152
XENOPORT INC COM 47,513 -2,884 (5.72) 6,508,622
INSMED INC COM PAR $.01 42,913 12,890 42.93 1,583,490
ALDER BIOPHARMACEUTICALS INC COM 40,830 33,712 473.58 879,581
PROGENICS PHARMACEUTICALS INC COM 37,678 -857 (2.23) 4,350,808
CATALYST PHARMACEUTICALS INC COM 37,373 4,199 12.66 7,565,462
ARRAY BIOPHARMA INC COM 32,877 24,547 294.67 5,658,755


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