BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,473

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.12%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.52%
Services
Technology
Transportation
Utilities

43 Activity Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,193,092 106,187 9.77 9,591,546
SEATTLE GENETICS INC COM 989,003 76,261 8.36 22,472,229
INCYTE CORP COM 804,629 542 .07 14,845,559
SYNAGEVA BIOPHARMA CORP COM 769,363 884 .12 10,660,432
GENOMIC HEALTH INC COM 405,824 22 .01 13,654,902
INTERMUNE INC COM 346,895 29,235 9.20 4,722,869
BIOCRYST PHARMACEUTICALS COM 147,027 67,822 85.63 10,890,872
BIOMARIN PHARMACEUTICAL INC COM 135,904 1,781 1.33 1,908,230
AVANIR PHARMACEUTICALS INC CL A NEW 115,434 79,419 220.52 18,558,487
XOMA CORP DEL COM 101,029 37 .04 23,065,972
ANACOR PHARMACEUTICALS INC COM 75,647 3,557 4.93 3,248,043
DYAX CORP COM 58,005 32,156 124.40 5,681,237
VANDA PHARMACEUTICALS INC COM 56,576 -952 (1.65) 4,372,153
CERUS CORP COM 38,527 6,735 21.19 10,246,591
CLOVIS ONCOLOGY INC COM 37,726 12,519 49.67 793,221
MALLINCKRODT PUB LTD CO SHS 36,548 -15,916 (30.34) 448,500
ACORDA THERAPEUTICS INC COM 29,520 -3,060 (9.39) 906,091
VERSARTIS INC COM 28,655 28,655 New 1,245,889
GILEAD SCIENCES INC COM 27,547 -32,268 (53.95) 256,108
HALOZYME THERAPEUTICS INC COM 26,373 -27,759 (51.28) 2,776,143