BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2013

Position Statistics

Total Positions 88
New Positions 14
Increased Positions 31
Decreased Positions 21
Positions with Activity 52
Sold Out Positions 4
Total Mkt Value (in $ millions) 5,021

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.33%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.78%
Services
Technology
Transportation
Utilities

88 Positions as of 12/31/2013

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SYNAGEVA BIOPHARMA CORP COM 810,554 New 10,273,182
SEATTLE GENETICS INC COM 805,383 54,880 7.31 20,735,926
PHARMACYCLICS INC COM 782,550 -26,117 (3.23) 8,719,218
INCYTE CORP COM 659,662 New 14,810,559
ACADIA PHARMACEUTICALS COM 387,928 New 19,955,126
GENOMIC HEALTH INC COM 365,979 New 13,650,835
BIOMARIN PHARMACEUTICAL INC COM 118,206 70,510 147.83 1,941,304
XOMA CORP DEL COM 96,966 New 23,032,372
INTERCEPT PHARMACEUTICALS INC COM 87,120 New 362,847
VANDA PHARMACEUTICALS INC COM 65,064 New 4,791,179
QUESTCOR PHARMACEUTICALS INC COM 59,703 17,700 42.14 775,864
BIOCRYST PHARMACEUTICALS COM 55,878 New 6,699,979
HALOZYME THERAPEUTICS INC COM 47,668 -5,455 (10.27) 6,297,026
MIRATI THERAPEUTICS INC COM 45,459 7,640 20.20 2,380,074
REPROS THERAPEUTICS INC COM NEW 44,403 New 2,778,654
ARROWHEAD RESH CORP COM NEW 39,459 -639 (1.59) 3,090,000
GILEAD SCIENCES INC COM 38,928 -48,278 (55.36) 556,108
ANACOR PHARMACEUTICALS INC COM 38,775 25,181 185.24 2,500,000
CERUS CORP COM 38,049 New 8,455,306
CLOVIS ONCOLOGY INC COM 29,111 12,560 75.89 530,738