BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 27
Decreased Positions 15
Positions with Activity 42
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,184

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.02%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.44%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,186,282 105,580 9.77 9,591,546
SYNAGEVA BIOPHARMA CORP COM 820,533 943 .12 10,660,432
INCYTE CORP COM 817,545 551 .07 14,845,559
SEATTLE GENETICS INC COM 807,877 62,294 8.36 22,472,229
ACADIA PHARMACEUTICALS COM 551,360 New 20,481,442
GENOMIC HEALTH INC COM 459,487 25 .01 13,654,902
AVANIR PHARMACEUTICALS INC CL A NEW 219,918 151,305 220.52 18,558,487
BIOMARIN PHARMACEUTICAL INC COM 154,624 2,026 1.33 1,908,230
BIOCRYST PHARMACEUTICALS COM 128,839 59,432 85.63 10,890,872
XOMA CORP DEL COM 99,184 36 .04 23,065,972
ANACOR PHARMACEUTICALS INC COM 92,114 4,331 4.93 3,248,043
DYAX CORP COM 61,414 34,046 124.40 5,681,237
VANDA PHARMACEUTICALS INC COM 48,575 -817 (1.65) 4,372,153
CLOVIS ONCOLOGY INC COM 44,087 14,630 49.67 793,221
CERUS CORP COM 42,421 7,416 21.19 10,246,591
MIRATI THERAPEUTICS INC COM 41,080 New 2,380,074
MALLINCKRODT PUB LTD CO SHS 40,800 -17,768 (30.34) 448,500
DERMA SCIENCES INC COM PAR $.01 31,374 New 3,537,137
ACORDA THERAPEUTICS INC COM 31,034 -3,216 (9.39) 906,091
GILEAD SCIENCES INC COM 28,354 -33,213 (53.95) 256,108


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