BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,591

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.07%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.6%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SYNAGEVA BIOPHARMA CORP COM 2,515,971 215,770 9.38 11,660,432
ABBVIE INC COM 2,428,997 -24,070 (0.98) 36,049,228
INCYTE CORP COM 1,602,133 New 14,845,559
SEATTLE GENETICS INC COM 1,227,260 43,137 3.64 28,876,712
ACADIA PHARMACEUTICALS COM 836,052 New 20,481,442
BIOMARIN PHARMACEUTICAL INC COM 544,127 63,022 13.10 4,200,456
GENOMIC HEALTH INC COM 374,064 17 .01 13,656,942
ANACOR PHARMACEUTICALS INC COM 290,335 New 4,204,702
DYAX CORP COM 160,894 -3,642 (2.21) 6,021,485
BIOCRYST PHARMACEUTICALS COM 118,613 -2,666 (2.2) 10,478,204
BELLICUM PHARMACEUTICALS INC COM 103,131 -2,292 (2.17) 4,190,594
MIRATI THERAPEUTICS INC COM 94,671 14,344 17.86 2,805,074
SPARK THERAPEUTICS INC COM 91,435 91,435 New 1,327,451
INVITAE CORP COM 85,411 85,411 New 6,554,967
CERUS CORP COM 63,294 8,642 15.81 13,553,275
XOMA CORP DEL COM 48,833 -7,355 (13.09) 14,708,613
VERSARTIS INC COM 44,899 10,490 30.49 2,977,396
ARRAY BIOPHARMA INC COM 43,799 32,701 294.67 5,658,755
XENOPORT INC COM 40,939 -2,485 (5.72) 6,508,622
HALOZYME THERAPEUTICS INC COM 40,062 -9,409 (19.02) 2,248,152