BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2015

Position Statistics

Total Positions 124
New Positions 8
Increased Positions 32
Decreased Positions 28
Positions with Activity 60
Sold Out Positions 9
Total Mkt Value (in $ millions) 8,799

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.25%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 91.93%
Services
Technology
Transportation
Utilities

124 Positions as of 06/30/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
INCYTE CORP COM 1,711,323 2,302 .14 14,865,559
SEATTLE GENETICS INC COM 1,213,819 78,386 6.90 30,870,262
ALEXION PHARMACEUTICALS INC COM 1,117,803 -193,254 (14.74) 6,542,599
ABBVIE INC COM 869,599 -40,386 (4.44) 14,373,538
ACADIA PHARMACEUTICALS COM 735,489 New 20,481,442
BIOMARIN PHARMACEUTICAL INC COM 510,391 -13,112 (2.51) 4,095,247
ANACOR PHARMACEUTICALS INC COM 467,689 -74,717 (13.78) 3,625,498
GENOMIC HEALTH INC COM 359,878 17 .01 13,657,598
DYAX CORP COM 174,703 41,989 31.64 7,926,630
BIOCRYST PHARMACEUTICALS COM 129,897 12,332 10.49 11,577,299
HERON THERAPEUTICS INC COM 100,378 7,150 7.67 2,807,784
MIRATI THERAPEUTICS INC COM 74,531 New 2,805,074
DBV TECHNOLOGIES S A SPONSORED ADR 71,595 13,180 22.56 1,862,019
BELLICUM PHARMACEUTICALS INC COM 69,061 New 4,190,594
INVITAE CORP COM 64,435 New 6,554,967
CERUS CORP COM 63,971 New 13,553,275
SPARK THERAPEUTICS INC COM 55,633 -2,868 (4.9) 1,262,382
XENOPORT INC COM 44,909 New 6,508,622
VERSARTIS INC COM 42,614 5,694 15.42 3,436,585
INSMED INC COM PAR $.01 37,038 New 1,583,490