BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 10,909

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.16%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.12%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 2,540,029 -25,171 (0.98) 36,049,228
INCYTE CORP COM 1,544,680 New 14,845,559
ALEXION PHARMACEUTICALS INC COM 1,415,419 121,387 9.38 7,673,730
SEATTLE GENETICS INC COM 1,370,200 48,161 3.64 28,876,712
ACADIA PHARMACEUTICALS COM 858,787 New 20,481,442
BIOMARIN PHARMACEUTICAL INC COM 566,389 65,600 13.10 4,200,456
GENOMIC HEALTH INC COM 380,756 17 .01 13,656,942
ANACOR PHARMACEUTICALS INC COM 321,534 New 4,204,702
DYAX CORP COM 156,679 -3,547 (2.21) 6,021,485
BIOCRYST PHARMACEUTICALS COM 153,191 -3,443 (2.2) 10,478,204
INVITAE CORP COM 98,456 98,456 New 6,554,967
BELLICUM PHARMACEUTICALS INC COM 89,637 -1,992 (2.17) 4,190,594
MIRATI THERAPEUTICS INC COM 87,434 13,247 17.86 2,805,074
SPARK THERAPEUTICS INC COM 79,474 79,474 New 1,327,451
HERON THERAPEUTICS INC COM 78,938 New 2,607,784
CERUS CORP COM 73,323 10,011 15.81 13,553,275
XOMA CORP DEL COM 57,658 -8,684 (13.09) 14,708,613
HALOZYME THERAPEUTICS INC COM 47,526 -11,162 (19.02) 2,248,152
VERSARTIS INC COM 47,400 11,075 30.49 2,977,396
DBV TECHNOLOGIES S A SPONSORED ADR 44,635 New 1,519,229