BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,198

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.09%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.64%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,151,081 102,447 9.77 9,591,546
SEATTLE GENETICS INC COM 972,149 74,961 8.36 22,472,229
SYNAGEVA BIOPHARMA CORP COM 801,664 921 .12 10,660,432
INCYTE CORP COM 773,751 521 .07 14,845,559
ACADIA PHARMACEUTICALS COM 462,266 New 20,481,442
GENOMIC HEALTH INC COM 381,791 21 .01 13,654,902
INTERMUNE INC COM 257,538 21,704 9.20 4,722,869
BIOCRYST PHARMACEUTICALS COM 145,938 67,319 85.63 10,890,872
BIOMARIN PHARMACEUTICAL INC COM 131,859 1,728 1.33 1,908,230
AVANIR PHARMACEUTICALS INC CL A NEW 107,825 74,184 220.52 18,558,487
XOMA CORP DEL COM 101,260 37 .04 23,065,972
ANACOR PHARMACEUTICALS INC COM 68,566 3,224 4.93 3,248,043
VANDA PHARMACEUTICALS INC COM 56,138 -944 (1.65) 4,372,153
DYAX CORP COM 55,847 30,959 124.40 5,681,237
MIRATI THERAPEUTICS INC COM 46,649 New 2,380,074
REPROS THERAPEUTICS INC COM NEW 41,207 New 2,778,654
CERUS CORP COM 38,527 6,735 21.19 10,246,591
CLOVIS ONCOLOGY INC COM 34,537 11,461 49.67 793,221
MALLINCKRODT PUB LTD CO SHS 31,175 -13,576 (30.34) 448,500
DERMA SCIENCES INC COM PAR $.01 31,091 New 3,537,137


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