BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,176

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.07%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.57%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,150,410 102,388 9.77 9,591,546
SEATTLE GENETICS INC COM 899,563 69,364 8.36 22,472,229
INCYTE CORP COM 703,828 474 .07 14,845,559
SYNAGEVA BIOPHARMA CORP COM 669,049 769 .12 10,660,432
ACADIA PHARMACEUTICALS COM 535,590 New 20,481,442
GENOMIC HEALTH INC COM 402,615 22 .01 13,654,902
INTERMUNE INC COM 348,264 29,350 9.20 4,722,869
AVANIR PHARMACEUTICALS INC CL A NEW 208,041 143,133 220.52 18,558,487
BIOMARIN PHARMACEUTICAL INC COM 131,821 1,727 1.33 1,908,230
BIOCRYST PHARMACEUTICALS COM 113,701 52,449 85.63 10,890,872
XOMA CORP DEL COM 102,182 37 .04 23,065,972
ANACOR PHARMACEUTICALS INC COM 80,227 3,772 4.93 3,248,043
DYAX CORP COM 59,369 32,912 124.40 5,681,237
VANDA PHARMACEUTICALS INC COM 50,455 -849 (1.65) 4,372,153
MIRATI THERAPEUTICS INC COM 42,603 New 2,380,074
CERUS CORP COM 40,679 7,111 21.19 10,246,591
MALLINCKRODT PUB LTD CO SHS 39,894 -17,373 (30.34) 448,500
CLOVIS ONCOLOGY INC COM 33,529 11,127 49.67 793,221
DERMA SCIENCES INC COM PAR $.01 29,853 New 3,537,137
GILEAD SCIENCES INC COM 27,012 -31,641 (53.95) 256,108