BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,677

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.89%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.73%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SYNAGEVA BIOPHARMA CORP COM 2,548,737 218,580 9.38 11,660,432
ABBVIE INC COM 2,412,775 -23,910 (0.98) 36,049,228
INCYTE CORP COM 1,628,261 New 14,845,559
SEATTLE GENETICS INC COM 1,252,961 44,041 3.64 28,876,712
ACADIA PHARMACEUTICALS COM 845,679 New 20,481,442
BIOMARIN PHARMACEUTICAL INC COM 520,983 60,341 13.10 4,200,456
GENOMIC HEALTH INC COM 367,235 17 .01 13,656,942
ANACOR PHARMACEUTICALS INC COM 291,554 New 4,204,702
DYAX CORP COM 152,886 -3,461 (2.21) 6,021,485
BIOCRYST PHARMACEUTICALS COM 124,376 -2,795 (2.2) 10,478,204
BELLICUM PHARMACEUTICALS INC COM 102,292 -2,273 (2.17) 4,190,594
SPARK THERAPEUTICS INC COM 98,457 98,457 New 1,327,451
INVITAE CORP COM 83,576 83,576 New 6,554,967
MIRATI THERAPEUTICS INC COM 75,372 11,420 17.86 2,805,074
CERUS CORP COM 69,528 9,493 15.81 13,553,275
HERON THERAPEUTICS INC COM 63,552 New 2,607,784
XOMA CORP DEL COM 51,480 -7,754 (13.09) 14,708,613
VERSARTIS INC COM 45,971 10,741 30.49 2,977,396
ARRAY BIOPHARMA INC COM 43,799 32,701 294.67 5,658,755
XENOPORT INC COM 40,549 -2,461 (5.72) 6,508,622


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