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BAKER BROS ADVISORS LLC Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2013

Position Statistics:

Total Positions 67
New Positions 8
Increased Positions 20
Decreased Positions 16
Positions with Activity 36
Sold Out Positions 5
Total Mkt Value
(in $ millions)		 3,968

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.09%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 99.91%
Services
Technology
Transportation
Utilities

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

67 Positions as of 03/31/2013

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 927,324 -44,188 (4.55) 10,923,830
SEATTLE GENETICS INC COM 709,152 New 19,322,947
GENOMIC HEALTH INC COM 468,503 8,100 1.76 12,577,272
SYNAGEVA BIOPHARMA CORP COM 367,728 34,277 10.28 9,223,182
INCYTE CORP COM 341,235 New 14,810,559
VIROPHARMA INC COM 220,720 -12,854 (5.5) 8,528,603
ACADIA PHARMACEUTICALS COM 207,301 New 15,621,812
XOMA CORP DEL COM 85,559 New 20,274,581
AEGERION PHARMACEUTICALS INC COM 53,181 15,347 40.56 863,743
BIOMARIN PHARMACEUTICAL INC COM 50,140 37,310 290.81 783,311
REPROS THERAPEUTICS INC COM NEW 37,739 12,736 50.94 2,261,154
CLOVIS ONCOLOGY INC COM 36,953 -4,208 (10.22) 1,001,163
CERUS CORP COM 35,855 24,295 210.16 6,542,845
ARIAD PHARMACEUTICALS INC COM 35,841 349 .98 2,150,000
AUXILIUM PHARMACEUTICALS INC COM 31,650 -33,960 (51.76) 2,108,617
INFINITY PHARMACEUTICALS INC COM 29,356 New 1,178,485
MEDIVATION INC COM 25,425 -20,515 (44.66) 534,919
HALOZYME THERAPEUTICS INC COM 25,331 11,243 79.81 3,182,251
VERTEX PHARMACEUTICALS INC COM 20,063 20,063 New 252,400
DERMA SCIENCES INC COM PAR $.01 19,418 New 1,358,857