BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 10,860

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.17%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.06%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 2,469,733 -24,474 (0.98) 36,049,228
INCYTE CORP COM 1,550,619 New 14,845,559
ALEXION PHARMACEUTICALS INC COM 1,410,892 120,998 9.38 7,673,730
SEATTLE GENETICS INC COM 1,380,884 48,537 3.64 28,876,712
ACADIA PHARMACEUTICALS COM 853,462 New 20,481,442
BIOMARIN PHARMACEUTICAL INC COM 574,328 66,520 13.10 4,200,456
GENOMIC HEALTH INC COM 373,381 17 .01 13,656,942
ANACOR PHARMACEUTICALS INC COM 335,493 New 4,204,702
DYAX CORP COM 160,412 -3,631 (2.21) 6,021,485
BIOCRYST PHARMACEUTICALS COM 152,563 -3,429 (2.2) 10,478,204
INVITAE CORP COM 98,652 98,652 New 6,554,967
MIRATI THERAPEUTICS INC COM 88,893 13,468 17.86 2,805,074
BELLICUM PHARMACEUTICALS INC COM 87,248 -1,939 (2.17) 4,190,594
HERON THERAPEUTICS INC COM 80,450 New 2,607,784
SPARK THERAPEUTICS INC COM 79,328 79,328 New 1,327,451
CERUS CORP COM 68,444 9,345 15.81 13,553,275
XOMA CORP DEL COM 55,157 -8,308 (13.09) 14,708,613
HALOZYME THERAPEUTICS INC COM 50,583 -11,880 (19.02) 2,248,152
DBV TECHNOLOGIES S A SPONSORED ADR 46,185 New 1,519,229
ALDER BIOPHARMACEUTICALS INC COM 44,797 36,987 473.58 879,581