BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2013

Position Statistics

Total Positions 88
New Positions 14
Increased Positions 31
Decreased Positions 21
Positions with Activity 52
Sold Out Positions 4
Total Mkt Value (in $ millions) 5,103

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.34%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.79%
Services
Technology
Transportation
Utilities

88 Positions as of 12/31/2013

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SEATTLE GENETICS INC COM 818,862 55,799 7.31 20,735,926
SYNAGEVA BIOPHARMA CORP COM 799,767 New 10,273,182
PHARMACYCLICS INC COM 776,010 -25,898 (3.23) 8,719,218
INCYTE CORP COM 702,761 New 14,810,559
ACADIA PHARMACEUTICALS COM 397,506 New 19,955,126
GENOMIC HEALTH INC COM 366,661 New 13,650,835
BIOMARIN PHARMACEUTICAL INC COM 119,080 71,031 147.83 1,941,304
XOMA CORP DEL COM 99,615 New 23,032,372
INTERCEPT PHARMACEUTICALS INC COM 87,849 New 362,847
VANDA PHARMACEUTICALS INC COM 70,430 New 4,791,179
BIOCRYST PHARMACEUTICALS COM 60,568 New 6,699,979
QUESTCOR PHARMACEUTICALS INC COM 60,230 17,856 42.14 775,864
HALOZYME THERAPEUTICS INC COM 48,424 -5,541 (10.27) 6,297,026
REPROS THERAPEUTICS INC COM NEW 48,043 New 2,778,654
MIRATI THERAPEUTICS INC COM 45,602 7,664 20.20 2,380,074
ARROWHEAD RESH CORP COM NEW 40,603 -657 (1.59) 3,090,000
ANACOR PHARMACEUTICALS INC COM 40,263 26,147 185.24 2,500,000
GILEAD SCIENCES INC COM 39,817 -49,382 (55.36) 556,108
CERUS CORP COM 38,725 New 8,455,306
CLOVIS ONCOLOGY INC COM 28,946 12,489 75.89 530,738