BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 100
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,485

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.07%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.6%
Services
Technology
Transportation
Utilities

100 Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SYNAGEVA BIOPHARMA CORP COM 845,040 29,760 3.65 10,648,182
PHARMACYCLICS INC COM 836,129 1,787 .21 8,737,888
SEATTLE GENETICS INC COM 775,655 131 .02 20,739,426
INCYTE CORP COM 754,017 1,271 .17 14,835,559
ACADIA PHARMACEUTICALS COM 456,736 11,737 2.64 20,481,442
GENOMIC HEALTH INC COM 364,566 89 .02 13,654,150
INTERMUNE INC COM 185,233 178,809 2,783.23 4,324,843
BIOMARIN PHARMACEUTICAL INC COM 111,657 -3,443 (2.99) 1,883,230
XOMA CORP DEL COM 97,995 107 .11 23,057,572
BIOCRYST PHARMACEUTICALS COM 71,460 -10,145 (12.43) 5,867,031
QUESTCOR PHARMACEUTICALS INC COM 66,722 -5,403 (7.49) 717,745
VANDA PHARMACEUTICALS INC COM 63,440 -4,930 (7.21) 4,445,696
INTERCEPT PHARMACEUTICALS INC COM 56,967 -23,658 (29.34) 256,375
HALOZYME THERAPEUTICS INC COM 55,659 -5,850 (9.51) 5,698,139
ANACOR PHARMACEUTICALS INC COM 53,642 10,317 23.81 3,095,318
GILEAD SCIENCES INC COM 49,343 New 556,108
REPROS THERAPEUTICS INC COM NEW 46,265 New 2,778,654
MIRATI THERAPEUTICS INC COM 42,389 New 2,380,074
DERMA SCIENCES INC COM PAR $.01 39,404 10,898 38.23 3,537,137
CERUS CORP COM 34,836 New 8,455,306


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