BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,571

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.13%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.63%
Services
Technology
Transportation
Utilities

101 Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,078,430 2,304 .21 8,737,888
SYNAGEVA BIOPHARMA CORP COM 774,229 27,266 3.65 10,648,182
SEATTLE GENETICS INC COM 744,338 126 .02 20,739,426
INCYTE CORP COM 732,432 1,234 .17 14,835,559
ACADIA PHARMACEUTICALS COM 434,411 11,163 2.64 20,481,442
GENOMIC HEALTH INC COM 359,787 87 .02 13,654,150
INTERMUNE INC COM 197,732 190,874 2,783.23 4,324,843
BIOMARIN PHARMACEUTICAL INC COM 115,047 -3,548 (2.99) 1,883,230
XOMA CORP DEL COM 93,614 102 .11 23,057,572
BIOCRYST PHARMACEUTICALS COM 75,450 -10,712 (12.43) 5,867,031
QUESTCOR PHARMACEUTICALS INC COM 66,284 -5,367 (7.49) 717,745
VANDA PHARMACEUTICALS INC COM 65,530 -5,092 (7.21) 4,445,696
INTERCEPT PHARMACEUTICALS INC COM 61,671 -25,612 (29.34) 256,375
HALOZYME THERAPEUTICS INC COM 52,594 -5,528 (9.51) 5,698,139
GILEAD SCIENCES INC COM 52,157 New 556,108
ANACOR PHARMACEUTICALS INC COM 52,001 10,001 23.81 3,095,318
MIRATI THERAPEUTICS INC COM 44,698 New 2,380,074
REPROS THERAPEUTICS INC COM NEW 39,929 New 2,778,654
DERMA SCIENCES INC COM PAR $.01 35,619 9,851 38.23 3,537,137
AVANIR PHARMACEUTICALS INC CL A NEW 31,267 1,952 6.66 5,790,139