BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 10,857

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.16%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.09%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▲ Change in Value ($1,000s) Change (%) Shares Held
AMICUS THERAPEUTICS INC COM -6,623 Sold Out 0
ASTERIAS BIOTHERAPEUTICS INC COM SER A -73 Sold Out 0
CELSUS THERAPEUTICS PLC SPONSORED ADR NE -418 Sold Out 0
GERON CORP COM -1,671 Sold Out 0
MALLINCKRODT PUB LTD CO SHS -5,575 Sold Out 0
QLT INC COM -6,589 Sold Out 0
SYNERGY PHARMACEUTICALS DEL COM NEW -9,032 Sold Out 0
TESARO INC COM -1,740 Sold Out 0
BIOTIME INC WT EXP 100118 26 -1 (2.15) 20,084
BIODEL INC COM NEW 30 30 New 30,179
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 85 New 13,253
APTOSE BIOSCIENCES INC COM NEW 167 -2,229 (93.03) 33,397
AEGERION PHARMACEUTICALS INC COM 266 266 New 14,300
CHEMOCENTRYX INC COM 393 -7 (1.87) 49,064
FIVE PRIME THERAPEUTICS INC COM 456 -14 (2.91) 19,247
CELLADON CORP COM 459 -10 (2.19) 366,806
ACHAOGEN INC COM 584 New 100,000
UNIQURE NV SHS 795 -18 (2.19) 30,000
ACCELERON PHARMA INC COM 857 New 28,765
OHR PHARMACEUTICAL INC COM NEW 919 919 New 370,370


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