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BAKER BROS ADVISORS LLC Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2013

Position Statistics:

Total Positions 67
New Positions 8
Increased Positions 20
Decreased Positions 16
Positions with Activity 36
Sold Out Positions 5
Total Mkt Value
(in $ millions)		 3,968

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.09%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 99.91%
Services
Technology
Transportation
Utilities

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

67 Positions as of 03/31/2013

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
DURATA THERAPEUTICS INC COM -1,205 Sold Out 0
IDERA PHARMACEUTICALS INC COM NEW -62 Sold Out 0
SEQUENOM INC COM NEW -53 Sold Out 0
SPECTRUM PHARMACEUTICALS INC COM -12,210 Sold Out 0
TRANZYME INC COM -2,632 Sold Out 0
ARADIGM CORP COM NEW 10 New 100,000
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 147 New 20,979
CUBIST PHARMACEUTICALS INC COM 248 New 5,000
ZIOPHARM ONCOLOGY INC COM 425 New 254,199
CHEMOCENTRYX INC COM 681 New 50,000
LPATH INC COM NEW 998 New 200,000
GERON CORP COM 1,120 New 1,000,000
TESARO INC COM 1,121 1,121 New 31,218
DISCOVERY LABORATORIES INC NEW COM NEW 1,279 New 852,617
AVEO PHARMACEUTICALS INC COM 1,565 1,565 New 519,833
AMICUS THERAPEUTICS INC COM 1,767 -858 (32.68) 515,072
BIODEL INC COM NEW 1,771 New 540,000
PROTHENA CORP PLC SHS 1,890 1,890 New 191,696
LIGAND PHARMACEUTICALS INC COM NEW 2,056 New 73,400
CYTRX CORP COM PAR $.001 2,450 New 1,000,000