BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2013

Position Statistics

Total Positions 88
New Positions 14
Increased Positions 31
Decreased Positions 21
Positions with Activity 52
Sold Out Positions 4
Total Mkt Value (in $ millions) 5,014

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.33%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.8%
Services
Technology
Transportation
Utilities

88 Positions as of 12/31/2013

Company Class Value of Shares ($1,000s) ▲ Change in Value ($1,000s) Change (%) Shares Held
ARIAD PHARMACEUTICALS INC COM -9,463 Sold Out 0
CUBIST PHARMACEUTICALS INC COM -320 Sold Out 0
MEI PHARMA INC COM NEW -2,987 Sold Out 0
TARGACEPT INC COM -8,438 Sold Out 0
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 192 New 20,979
CHEMOCENTRYX INC COM 265 -795 (75) 50,000
FIVE PRIME THERAPEUTICS INC COM 290 290 New 19,823
SALIX PHARMACEUTICALS INC COM 364 New 3,621
CONTRAVIR PHARMACEUTICALS INC COM 509 New 257,176
FOUNDATION MEDICINE INC COM 544 544 New 20,000
GERON CORP COM 793 -1,177 (59.74) 402,629
TESARO INC COM 798 New 31,218
ZIOPHARM ONCOLOGY INC COM 859 New 254,199
AMICUS THERAPEUTICS INC COM 937 New 515,072
GALECTIN THERAPEUTICS INC COM NEW 1,034 1,034 New 100,600
ACCELERON PHARMA INC COM 1,134 1,134 New 30,000
ACHILLION PHARMACEUTICALS INC COM 1,269 New 455,000
VENTRUS BIOSCIENCES INC COM 1,301 New 1,215,840
RIGEL PHARMACEUTICALS INC COM NEW 1,600 New 500,000
ORASURE TECHNOLOGIES INC COM 1,624 New 243,467


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