BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 109
New Positions 14
Increased Positions 27
Decreased Positions 13
Positions with Activity 40
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,911

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.06%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 95.15%
Services
Technology
Transportation
Utilities

109 Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▲ Change in Value ($1,000s) Change (%) Shares Held
DAIICHI SANKYO CO LTD SPON ADR LEV 1 -19,265 Sold Out 0
BIOTIME INC WT EXP 100118 47 47 New 20,525
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 93 New 13,253
ASTERIAS BIOTHERAPEUTICS INC COM SER A 177 177 New 16,775
CHEMOCENTRYX INC COM 355 New 50,000
FIVE PRIME THERAPEUTICS INC COM 411 New 19,823
CELSUS THERAPEUTICS PLC SPONSORED ADR NE 505 New 673,887
ACHAOGEN INC COM 561 New 100,000
UNIQURE NV SHS 754 New 30,672
ACCELERON PHARMA INC COM 827 New 28,765
CELLADON CORP COM 983 New 375,000
LOXO ONCOLOGY INC COM 1,135 New 100,000
SYNTA PHARMACEUTICALS CORP COM 1,195 New 500,000
ALNYLAM PHARMACEUTICALS INC COM 1,240 New 11,600
MEDIWOUND LTD ORD SHS 1,350 New 225,000
DERMIRA INC COM 1,478 1,478 New 100,000
ORASURE TECHNOLOGIES INC COM 1,497 New 234,664
GERON CORP COM 1,582 New 402,629
TESARO INC COM 1,675 New 31,218
OPHTHOTECH CORP COM 1,691 New 36,776


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