BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 110
New Positions 14
Increased Positions 28
Decreased Positions 13
Positions with Activity 41
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,644

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.01%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 94.86%
Services
Technology
Transportation
Utilities

110 Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▲ Change in Value ($1,000s) Change (%) Shares Held
DAIICHI SANKYO CO LTD SPON ADR LEV 1 -17,242 Sold Out 0
BIOTIME INC WT EXP 100118 25 25 New 20,525
ASTERIAS BIOTHERAPEUTICS INC COM SER A 66 66 New 16,775
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 93 New 13,253
CHEMOCENTRYX INC COM 411 New 50,000
FIVE PRIME THERAPEUTICS INC COM 537 New 19,823
CELSUS THERAPEUTICS PLC SPONSORED ADR NE 561 New 673,887
UNIQURE NV SHS 664 New 30,672
ACHAOGEN INC COM 1,120 New 100,000
ACCELERON PHARMA INC COM 1,169 New 28,765
SYNTA PHARMACEUTICALS CORP COM 1,180 New 500,000
ALNYLAM PHARMACEUTICALS INC COM 1,237 New 11,600
GERON CORP COM 1,264 New 402,629
LOXO ONCOLOGY INC COM 1,292 New 100,000
RIGEL PHARMACEUTICALS INC COM NEW 1,518 New 481,972
TESARO INC COM 1,631 New 31,218
MEDIWOUND LTD ORD SHS 1,670 New 225,000
DERMIRA INC COM 1,691 1,691 New 100,000
ORASURE TECHNOLOGIES INC COM 1,788 New 234,664
PROTEON THERAPEUTICS INC COM 1,838 1,838 New 172,917


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