BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 110
New Positions 14
Increased Positions 28
Decreased Positions 13
Positions with Activity 41
Sold Out Positions 1
Total Mkt Value (in $ millions) 9,038

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.1%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 95.01%
Services
Technology
Transportation
Utilities

110 Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held ▲
DAIICHI SANKYO CO LTD SPON ADR LEV 1 -17,717 Sold Out 0
ALNYLAM PHARMACEUTICALS INC COM 1,207 New 11,600
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 86 New 13,253
ASTERIAS BIOTHERAPEUTICS INC COM SER A 125 125 New 16,775
FIVE PRIME THERAPEUTICS INC COM 447 New 19,823
BIOTIME INC WT EXP 100118 42 42 New 20,525
RECEPTOS INC COM 3,524 New 23,900
ACCELERON PHARMA INC COM 1,080 New 28,765
UNIQURE NV SHS 770 New 30,672
TESARO INC COM 1,745 New 31,218
OPHTHOTECH CORP COM 1,805 New 36,776
MALLINCKRODT PUB LTD CO SHS 6,048 -20,114 (76.88) 46,666
CHEMOCENTRYX INC COM 362 New 50,000
LIGAND PHARMACEUTICALS INC COM NEW 5,355 New 73,400
SAGE THERAPEUTICS INC COM 3,803 New 75,000
ENANTA PHARMACEUTICALS INC COM 2,362 New 75,357
KARYOPHARM THERAPEUTICS INC COM 2,798 New 94,095
ISIS PHARMACEUTICALS INC COM 6,103 New 96,303
ACHAOGEN INC COM 970 New 100,000
DERMIRA INC COM 1,514 1,514 New 100,000