BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,473

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.12%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.52%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held ▲
ASSEMBLY BIOSCIENCES INC COM -606 Sold Out 0
AUXILIUM PHARMACEUTICALS INC COM -1,089 Sold Out 0
INTERCEPT PHARMACEUTICALS INC COM -74,277 Sold Out 0
PORTOLA PHARMACEUTICALS INC COM -5,092 Sold Out 0
PROTHENA CORP PLC SHS -5,270 Sold Out 0
RETROPHIN INC COM -2,697 Sold Out 0
ALNYLAM PHARMACEUTICALS INC COM 808 New 11,600
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 106 New 13,253
ASTERIAS BIOTHERAPEUTICS INC COM SER A 60 New 16,774
FIVE PRIME THERAPEUTICS INC COM 231 New 19,823
RECEPTOS INC COM 1,222 New 23,900
ACCELERON PHARMA INC COM 773 New 28,765
UNIQURE NV SHS 353 New 30,672
TESARO INC COM 923 New 31,218
OPHTHOTECH CORP COM 1,433 New 36,776
CHEMOCENTRYX INC COM 256 New 50,000
LIGAND PHARMACEUTICALS INC COM NEW 3,820 New 73,400
ENANTA PHARMACEUTICALS INC COM 3,162 -235 (6.92) 75,357
FOUNDATION MEDICINE INC COM 1,819 1,819 New 78,162
KARYOPHARM THERAPEUTICS INC COM 3,387 1,260 59.23 94,095