BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2013

Position Statistics

Total Positions 88
New Positions 14
Increased Positions 31
Decreased Positions 21
Positions with Activity 52
Sold Out Positions 4
Total Mkt Value (in $ millions) 5,248

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.29%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.77%
Services
Technology
Transportation
Utilities

88 Positions as of 12/31/2013

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held ▲
ARIAD PHARMACEUTICALS INC COM -10,003 Sold Out 0
CUBIST PHARMACEUTICALS INC COM -332 Sold Out 0
MEI PHARMA INC COM NEW -3,132 Sold Out 0
TARGACEPT INC COM -8,790 Sold Out 0
SALIX PHARMACEUTICALS INC COM 398 New 3,621
FIVE PRIME THERAPEUTICS INC COM 290 290 New 19,823
FOUNDATION MEDICINE INC COM 532 532 New 20,000
UNITED THERAPEUTICS CORP DEL COM 1,873 -3,369 (64.28) 20,000
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 195 New 20,979
PUMA BIOTECHNOLOGY INC COM 1,946 -5,837 (75) 25,000
ACCELERON PHARMA INC COM 1,003 1,003 New 30,000
TESARO INC COM 792 New 31,218
CHEMOCENTRYX INC COM 290 -870 (75) 50,000
KARYOPHARM THERAPEUTICS INC COM 1,727 1,727 New 61,330
LIGAND PHARMACEUTICALS INC COM NEW 5,078 New 73,400
GW PHARMACEUTICALS PLC ADS 6,528 6,528 New 94,172
MACROGENICS INC COM 2,065 2,065 New 100,000
RECEPTOS INC COM 3,672 New 100,000
GALECTIN THERAPEUTICS INC COM NEW 1,217 1,217 New 100,600
OPHTHOTECH CORP COM 3,618 3,618 New 103,040