BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2015

Position Statistics

Total Positions 126
New Positions 12
Increased Positions 39
Decreased Positions 12
Positions with Activity 51
Sold Out Positions 4
Total Mkt Value (in $ millions) 8,350

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.77%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.24%
Services
Technology
Transportation
Utilities

126 Positions as of 09/30/2015

Company ▲ Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 815,842 New 14,373,538
ACADIA PHARMACEUTICALS COM 415,568 New 20,481,442
ACCELERON PHARMA INC COM 805 New 28,765
ACHAOGEN INC COM 383 New 100,000
ACHILLION PHARMACEUTICALS INC COM 13,400 3,191 31.26 2,000,000
ACORDA THERAPEUTICS INC COM 40,892 13,345 48.44 1,096,876
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 755 New 100,000
AERIE PHARMACEUTICALS INC COM 4,900 New 299,356
AFFIMED N V COM 1,328 New 400,000
AGIOS PHARMACEUTICALS INC COM 3,794 New 100,000
AIMMUNE THERAPEUTICS INC COM 4,018 4,018 New 250,000
AKARI THERAPEUTICS PLC SPONSORED ADR 4,927 4,927 New 395,882
ALCOBRA LTD SHS 8,544 -782 (8.38) 1,639,871
ALDER BIOPHARMACEUTICALS INC COM 12,369 -9,112 (42.42) 513,439
ALDEYRA THERAPEUTICS INC COM 611 New 142,000
ALEXION PHARMACEUTICALS INC COM 955,350 New 6,542,599
ALNYLAM PHARMACEUTICALS INC COM 766 New 11,340
AMARIN CORP PLC SPONS ADR NEW 3,198 New 2,205,710
ANACOR PHARMACEUTICALS INC COM 325,167 40,095 14.07 4,135,412
APTOSE BIOSCIENCES INC COM NEW 97 New 33,397


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