BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2015

Position Statistics

Total Positions 127
New Positions 5
Increased Positions 30
Decreased Positions 12
Positions with Activity 42
Sold Out Positions 7
Total Mkt Value (in $ millions) 9,143

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.69%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.16%
Services
Technology
Transportation
Utilities

127 Positions as of 12/31/2015

Company ▲ Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 876,786 New 14,373,538
ACADIA PHARMACEUTICALS COM 661,551 New 20,481,442
ACCELERON PHARMA INC COM 862 New 28,765
ACHAOGEN INC COM 339 New 100,000
ACHILLION PHARMACEUTICALS INC COM 17,100 New 2,000,000
ACORDA THERAPEUTICS INC COM 92,546 64,192 226.39 3,580,112
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 969 New 100,000
ADVANCED ACCELERATOR APPLIC SPONSORED ADS 19,702 19,702 New 567,454
AERIE PHARMACEUTICALS INC COM 4,748 New 299,356
AFFIMED N V COM 1,620 New 400,000
AGIOS PHARMACEUTICALS INC COM 4,895 New 100,000
AIMMUNE THERAPEUTICS INC COM 3,238 New 250,000
AKARI THERAPEUTICS PLC SPONSORED ADR 6,809 New 395,882
ALCOBRA LTD SHS 9,369 2,793 42.47 2,336,359
ALDER BIOPHARMACEUTICALS INC COM -13,632 Sold Out 0
ALDEYRA THERAPEUTICS INC COM 895 New 142,000
ALEXION PHARMACEUTICALS INC COM 911,253 New 6,542,599
ALKERMES PLC SHS 9,947 9,947 New 250,251
ALNYLAM PHARMACEUTICALS INC COM 760 New 11,340
AMARIN CORP PLC SPONS ADR NEW 4,036 New 2,205,710


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