BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,473

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.12%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.52%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company ▲ Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ACADIA PHARMACEUTICALS COM 491,145 New 20,481,442
ACCELERON PHARMA INC COM 773 New 28,765
ACHAOGEN INC COM 951 New 100,000
ACHILLION PHARMACEUTICALS INC COM 5,072 New 438,337
ACORDA THERAPEUTICS INC COM 29,520 -3,060 (9.39) 906,091
AEGERION PHARMACEUTICALS INC COM 12,645 -3,055 (19.46) 413,922
AERIE PHARMACEUTICALS INC COM 4,903 New 299,356
AGIOS PHARMACEUTICALS INC COM 9,239 New 199,893
ALDER BIOPHARMACEUTICALS INC COM 2,613 2,613 New 153,350
ALNYLAM PHARMACEUTICALS INC COM 808 New 11,600
AMBIT BIOSCIENCES CORP COM 5,662 New 747,954
AMICUS THERAPEUTICS INC COM 3,463 New 481,697
ANACOR PHARMACEUTICALS INC COM 75,647 3,557 4.93 3,248,043
AQUINOX PHARMACEUTICALS INC COM 9,949 New 1,211,851
ARRAY BIOPHARMA INC COM 5,663 New 1,433,797
ARROWHEAD RESH CORP COM NEW 20,847 10,181 95.45 1,430,802
ASSEMBLY BIOSCIENCES INC COM -606 Sold Out 0
ASTERIAS BIOTHERAPEUTICS INC COM SER A 60 New 16,774
AUXILIUM PHARMACEUTICALS INC COM -1,089 Sold Out 0
AVANIR PHARMACEUTICALS INC CL A NEW 115,434 79,419 220.52 18,558,487