BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2016

Position Statistics

Total Positions 125
New Positions 5
Increased Positions 34
Decreased Positions 13
Positions with Activity 47
Sold Out Positions 5
Total Mkt Value (in $ millions) 8,881

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.25%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 91.33%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2016

Company ▲ Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 881,242 New 14,373,538
ACADIA PHARMACEUTICALS COM 811,164 125,035 18.22 24,213,838
ACCELERON PHARMA INC COM 1,008 New 28,765
ACHAOGEN INC COM 399 New 100,000
ACHILLION PHARMACEUTICALS INC COM 21,562 4,142 23.78 2,475,515
ACORDA THERAPEUTICS INC COM 96,323 2,130 2.26 3,661,082
ADAMAS PHARMACEUTICALS INC COM 2,804 2,804 New 172,630
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 923 New 100,000
ADVANCED ACCELERATOR APPLIC SPONSORED ADS 17,750 1,373 8.39 615,033
AERIE PHARMACEUTICALS INC COM 5,442 New 299,356
AFFIMED N V COM 1,308 New 400,000
AGIOS PHARMACEUTICALS INC COM 14,934 10,084 207.92 307,915
AIMMUNE THERAPEUTICS INC COM 3,078 New 250,000
AKARI THERAPEUTICS PLC SPONSORED ADR 5,562 New 395,882
ALCOBRA LTD SHS 9,579 New 2,336,359
ALDEYRA THERAPEUTICS INC COM 730 New 142,000
ALEXION PHARMACEUTICALS INC COM 808,469 New 6,542,599
ALKERMES PLC SHS 10,948 New 250,251
ALNYLAM PHARMACEUTICALS INC COM 646 New 11,340
AMARIN CORP PLC SPONS ADR NEW 1,684 -2,948 (63.65) 801,860