BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,595

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.13%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.51%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company ▲ Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 2,432,241 -24,102 (0.98) 36,049,228
ACADIA PHARMACEUTICALS COM 823,149 New 20,481,442
ACCELERON PHARMA INC COM 956 New 28,765
ACHAOGEN INC COM 611 New 100,000
ACHILLION PHARMACEUTICALS INC COM 2,001 -2,093 (51.13) 214,237
ACORDA THERAPEUTICS INC COM 22,522 -507 (2.2) 738,916
AEGERION PHARMACEUTICALS INC COM 281 281 New 14,300
AERIE PHARMACEUTICALS INC COM 3,350 New 299,356
AFFIMED N V COM 4,036 New 400,000
AGIOS PHARMACEUTICALS INC COM 18,624 -1,669 (8.23) 149,954
ALCOBRA LTD SHS 13,317 11,160 517.47 1,789,871
ALDER BIOPHARMACEUTICALS INC COM 37,154 30,676 473.58 879,581
ALDEYRA THERAPEUTICS INC COM 1,064 1,064 New 142,000
ALNYLAM PHARMACEUTICALS INC COM 1,457 -33 (2.24) 11,340
AMARIN CORP PLC SPONS ADR NEW 5,117 5,117 New 2,205,710
AMICUS THERAPEUTICS INC COM -5,872 Sold Out 0
ANACOR PHARMACEUTICALS INC COM 293,446 New 4,204,702
APTOSE BIOSCIENCES INC COM NEW 194 -2,585 (93.03) 33,397
AQUINOX PHARMACEUTICALS INC COM 8,639 -165 (1.87) 1,187,666
ARRAY BIOPHARMA INC COM 43,233 32,279 294.67 5,658,755