BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,315

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.12%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.59%
Services
Technology
Transportation
Utilities

101 Positions as of 03/31/2014

Company ▲ Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ACADIA PHARMACEUTICALS COM 422,327 10,853 2.64 20,481,442
ACCELERON PHARMA INC COM 809 -35 (4.12) 28,765
ACHAOGEN INC COM 1,110 1,110 New 100,000
ACHILLION PHARMACEUTICALS INC COM 3,165 -120 (3.66) 438,337
ACORDA THERAPEUTICS INC COM 29,510 29,510 New 1,000,000
AEGERION PHARMACEUTICALS INC COM 15,418 418 2.78 513,922
AERIE PHARMACEUTICALS INC COM 5,870 -13 (0.22) 299,356
AGIOS PHARMACEUTICALS INC COM 7,638 -224 (2.85) 199,893
ALNYLAM PHARMACEUTICALS INC COM 636 636 New 11,600
AMBIT BIOSCIENCES CORP COM 4,106 New 747,954
AMICUS THERAPEUTICS INC COM 2,144 -149 (6.48) 481,697
ANACOR PHARMACEUTICALS INC COM 51,599 9,924 23.81 3,095,318
AQUINOX PHARMACEUTICALS INC COM 9,695 9,695 New 1,211,851
ARRAY BIOPHARMA INC COM 5,993 -277 (4.41) 1,433,797
ARROWHEAD RESH CORP COM NEW 8,228 -26,503 (76.31) 732,062
ASSEMBLY BIOSCIENCES INC COM 591 -1,129 (65.65) 83,538
ASTERIAS BIOTHERAPEUTICS INC COM SER A 46 New 16,774
AUXILIUM PHARMACEUTICALS INC COM 1,108 1,108 New 58,544
AVANIR PHARMACEUTICALS INC CL A NEW 30,225 1,887 6.66 5,790,139
BIOCRYST PHARMACEUTICALS COM 68,996 -9,795 (12.43) 5,867,031