BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 9,989

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.2%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.61%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company ▲ Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 1,053,026 -10,435 (0.98) 15,041,077
ACADIA PHARMACEUTICALS COM 999,699 New 20,481,442
ACCELERON PHARMA INC COM 824 New 28,765
ACHAOGEN INC COM 721 New 100,000
ACHILLION PHARMACEUTICALS INC COM 1,825 -1,909 (51.13) 214,237
ACORDA THERAPEUTICS INC COM 25,389 -571 (2.2) 738,916
AEGERION PHARMACEUTICALS INC COM 274 274 New 14,300
AERIE PHARMACEUTICALS INC COM 5,430 New 299,356
AFFIMED N V COM 6,564 New 400,000
AGIOS PHARMACEUTICALS INC COM 16,522 -1,481 (8.23) 149,954
ALCOBRA LTD SHS 13,227 11,085 517.47 1,789,871
ALDER BIOPHARMACEUTICALS INC COM 40,830 33,712 473.58 879,581
ALDEYRA THERAPEUTICS INC COM 1,262 1,262 New 142,000
ALEXION PHARMACEUTICALS INC COM 1,515,101 129,935 9.38 7,673,730
ALNYLAM PHARMACEUTICALS INC COM 1,445 -33 (2.24) 11,340
AMARIN CORP PLC SPONS ADR NEW 4,985 4,985 New 2,205,710
AMICUS THERAPEUTICS INC COM -8,280 Sold Out 0
ANACOR PHARMACEUTICALS INC COM 627,299 New 4,204,702
APTOSE BIOSCIENCES INC COM NEW 153 -2,038 (93.03) 33,397
AQUINOX PHARMACEUTICALS INC COM 2,185 -42 (1.87) 1,187,666