BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,571

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.13%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.63%
Services
Technology
Transportation
Utilities

101 Positions as of 03/31/2014

Company Class ▲ Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
GW PHARMACEUTICALS PLC ADS -8,257 Sold Out 0
AVANIR PHARMACEUTICALS INC CL A NEW 31,267 1,952 6.66 5,790,139
ACADIA PHARMACEUTICALS COM 434,411 11,163 2.64 20,481,442
ACCELERON PHARMA INC COM 882 -38 (4.12) 28,765
ACHAOGEN INC COM 1,122 1,122 New 100,000
ACHILLION PHARMACEUTICALS INC COM 3,191 -121 (3.66) 438,337
ACORDA THERAPEUTICS INC COM 29,820 29,820 New 1,000,000
AEGERION PHARMACEUTICALS INC COM 18,321 496 2.78 513,922
AERIE PHARMACEUTICALS INC COM 5,682 -12 (0.22) 299,356
AGIOS PHARMACEUTICALS INC COM 8,014 -235 (2.85) 199,893
ALNYLAM PHARMACEUTICALS INC COM 644 644 New 11,600
AMBIT BIOSCIENCES CORP COM 4,263 New 747,954
AMICUS THERAPEUTICS INC COM 2,158 -150 (6.48) 481,697
ANACOR PHARMACEUTICALS INC COM 52,001 10,001 23.81 3,095,318
AQUINOX PHARMACEUTICALS INC COM 9,404 9,404 New 1,211,851
ARRAY BIOPHARMA INC COM 6,079 -281 (4.41) 1,433,797
ASSEMBLY BIOSCIENCES INC COM 548 -1,047 (65.65) 83,538
AUXILIUM PHARMACEUTICALS INC COM 1,190 1,190 New 58,544
BIOCRYST PHARMACEUTICALS COM 75,450 -10,712 (12.43) 5,867,031
BIODELIVERY SCIENCES INTL INC COM 5,650 -5,704 (50.24) 421,005