BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 103
New Positions 8
Increased Positions 29
Decreased Positions 18
Positions with Activity 47
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,749

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.98%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.06%
Services
Technology
Transportation
Utilities

103 Positions as of 09/30/2014

Company Class ▲ Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) Shares Held
AVANIR PHARMACEUTICALS INC CL A NEW 354,472 40,834 13.02 20,974,677
ACADIA PHARMACEUTICALS COM 617,925 New 20,481,442
ACCELERON PHARMA INC COM 1,093 New 28,765
ACHAOGEN INC COM 1,299 New 100,000
ACHILLION PHARMACEUTICALS INC COM 5,190 New 438,337
ACORDA THERAPEUTICS INC COM 28,930 -5,864 (16.85) 753,391
AEGERION PHARMACEUTICALS INC COM -9,048 Sold Out 0
AERIE PHARMACEUTICALS INC COM 8,460 New 299,356
AFFIMED N V COM 2,466 2,466 New 400,000
AGIOS PHARMACEUTICALS INC COM 18,216 -3,217 (15.01) 169,893
ALDER BIOPHARMACEUTICALS INC COM 3,871 New 153,350
ALNYLAM PHARMACEUTICALS INC COM 1,074 New 11,600
AMICUS THERAPEUTICS INC COM 3,796 New 481,697
ANACOR PHARMACEUTICALS INC COM 127,907 29,102 29.45 4,204,702
AQUINOX PHARMACEUTICALS INC COM 7,986 New 1,211,851
ARRAY BIOPHARMA INC COM 6,552 New 1,433,797
AURINIA PHARMACEUTICALS INC COM 2,663 2,663 New 727,669
BIOCRYST PHARMACEUTICALS COM 118,601 -1,961 (1.63) 10,713,686
BIODELIVERY SCIENCES INTL INC COM 2,518 -2,530 (50.11) 210,021
BIOMARIN PHARMACEUTICAL INC COM 206,918 40,348 24.22 2,370,464