BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2015

Position Statistics

Total Positions 124
New Positions 8
Increased Positions 32
Decreased Positions 28
Positions with Activity 60
Sold Out Positions 9
Total Mkt Value (in $ millions) 8,928

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.21%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.13%
Services
Technology
Transportation
Utilities

124 Positions as of 06/30/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) ▲ Shares Held
AEGERION PHARMACEUTICALS INC COM -253 Sold Out 0
BIODEL INC COM NEW -22 Sold Out 0
CELLADON CORP COM -440 Sold Out 0
INFINITY PHARMACEUTICALS INC COM -2,639 Sold Out 0
LIPOCINE INC NEW COM -8,336 Sold Out 0
ORASURE TECHNOLOGIES INC COM -1,181 Sold Out 0
RIGEL PHARMACEUTICALS INC COM NEW -1,064 Sold Out 0
SYNTA PHARMACEUTICALS CORP COM -993 Sold Out 0
TRANSITION THERAPEUTICS INC COM NEW -1,654 Sold Out 0
FOUNDATION MEDICINE INC COM 487 -2,410 (83.19) 20,892
VANDA PHARMACEUTICALS INC COM 4,964 -16,232 (76.58) 409,881
AGIOS PHARMACEUTICALS INC COM 8,461 -4,227 (33.31) 100,000
ARROWHEAD RESH CORP COM NEW 5,572 -1,549 (21.76) 1,009,509
JUNO THERAPEUTICS INC COM 2,874 -718 (20) 80,000
BIODELIVERY SCIENCES INTL INC COM 1,338 -292 (17.92) 210,021
ULTRAGENYX PHARMACEUTICAL INC COM 14,408 -2,907 (16.79) 123,894
ALEXION PHARMACEUTICALS INC COM 1,125,196 -194,532 (14.74) 6,542,599
HALOZYME THERAPEUTICS INC COM 32,616 -5,356 (14.11) 1,931,057
ANACOR PHARMACEUTICALS INC COM 482,010 -77,005 (13.78) 3,625,498
SPARK THERAPEUTICS INC COM 51,328 -2,646 (4.9) 1,262,382