BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 9,989

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.2%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.61%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) ▲ Shares Held
AMICUS THERAPEUTICS INC COM -8,280 Sold Out 0
ASTERIAS BIOTHERAPEUTICS INC COM SER A -83 Sold Out 0
CELSUS THERAPEUTICS PLC SPONSORED ADR NE -384 Sold Out 0
GERON CORP COM -1,631 Sold Out 0
MALLINCKRODT PUB LTD CO SHS -5,785 Sold Out 0
QLT INC COM -5,790 Sold Out 0
SYNERGY PHARMACEUTICALS DEL COM NEW -8,876 Sold Out 0
TESARO INC COM -1,811 Sold Out 0
APTOSE BIOSCIENCES INC COM NEW 153 -2,038 (93.03) 33,397
TEKMIRA PHARMACEUTICALS CORP COM NEW 1,956 -3,288 (62.7) 180,582
VANDA PHARMACEUTICALS INC COM 21,423 -33,316 (60.86) 1,750,230
IRONWOOD PHARMACEUTICALS INC COM CL A 1,768 -1,850 (51.13) 169,163
ACHILLION PHARMACEUTICALS INC COM 1,825 -1,909 (51.13) 214,237
ISIS PHARMACEUTICALS INC COM 3,139 -2,151 (40.67) 57,140
CHIMERIX INC COM 6,192 -3,074 (33.18) 115,216
RIGEL PHARMACEUTICALS INC COM NEW 1,064 -372 (25.89) 357,187
BIOTA PHARMACEUTIALS INC COM 2,037 -575 (22.02) 863,184
HALOZYME THERAPEUTICS INC COM 52,472 -12,323 (19.02) 2,248,152
XOMA CORP DEL COM 10,752 -1,619 (13.09) 14,708,613
AGIOS PHARMACEUTICALS INC COM 16,522 -1,481 (8.23) 149,954


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