BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,379

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.12%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.58%
Services
Technology
Transportation
Utilities

101 Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) ▲ Shares Held
CONTRAVIR PHARMACEUTICALS INC COM -352 Sold Out 0
FOUNDATION MEDICINE INC COM -560 Sold Out 0
GW PHARMACEUTICALS PLC ADS -8,163 Sold Out 0
MEDIVATION INC COM -31,002 Sold Out 0
PUMA BIOTECHNOLOGY INC COM -5,836 Sold Out 0
UNITED THERAPEUTICS CORP DEL COM -1,876 Sold Out 0
ARROWHEAD RESH CORP COM NEW 8,536 -27,494 (76.31) 732,062
RECEPTOS INC COM 933 -2,970 (76.1) 23,900
ASSEMBLY BIOSCIENCES INC COM 595 -1,137 (65.65) 83,538
OPHTHOTECH CORP COM 1,494 -2,692 (64.31) 36,776
ISIS PHARMACEUTICALS INC COM 3,023 -4,732 (61.02) 96,303
BIODELIVERY SCIENCES INTL INC COM 5,254 -5,304 (50.24) 421,005
STEMLINE THERAPEUTICS INC COM 4,200 -4,171 (49.83) 338,671
IDERA PHARMACEUTICALS INC COM NEW 4,452 -4,302 (49.14) 1,613,076
CYCLACEL PHARMACEUTICALS INC PFD CONV EX 6% 103 -60 (36.83) 13,253
SYNERGY PHARMACEUTICALS DEL COM NEW 6,699 -3,239 (32.59) 1,758,271
PROTHENA CORP PLC SHS 4,361 -2,023 (31.69) 230,142
INSMED INC COM PAR $.01 10,039 -4,391 (30.43) 554,050
INTERCEPT PHARMACEUTICALS INC COM 59,441 -24,686 (29.34) 256,375
ENANTA PHARMACEUTICALS INC COM 3,162 -1,099 (25.79) 80,957