BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 27
Decreased Positions 15
Positions with Activity 42
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,103

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.06%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.4%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) ▲ Shares Held
ASSEMBLY BIOSCIENCES INC COM -707 Sold Out 0
AUXILIUM PHARMACEUTICALS INC COM -1,828 Sold Out 0
INTERCEPT PHARMACEUTICALS INC COM -58,835 Sold Out 0
PORTOLA PHARMACEUTICALS INC COM -4,983 Sold Out 0
PROTHENA CORP PLC SHS -4,734 Sold Out 0
RETROPHIN INC COM -1,855 Sold Out 0
GILEAD SCIENCES INC COM 27,450 -32,154 (53.95) 256,108
HALOZYME THERAPEUTICS INC COM 25,707 -27,058 (51.28) 2,776,143
INSMED INC COM PAR $.01 4,357 -3,583 (45.12) 304,050
GALECTIN THERAPEUTICS INC COM NEW 1,422 -948 (40) 300,000
MALLINCKRODT PUB LTD CO SHS 40,029 -17,432 (30.34) 448,500
AEGERION PHARMACEUTICALS INC COM 13,759 -3,324 (19.46) 413,922
ACORDA THERAPEUTICS INC COM 31,740 -3,290 (9.39) 906,091
ENANTA PHARMACEUTICALS INC COM 3,389 -252 (6.92) 75,357
VANDA PHARMACEUTICALS INC COM 45,164 -760 (1.65) 4,372,153
ACADIA PHARMACEUTICALS COM 537,638 New 20,481,442
ACCELERON PHARMA INC COM 921 New 28,765
ACHAOGEN INC COM 936 New 100,000
ACHILLION PHARMACEUTICALS INC COM 4,918 New 438,337
AERIE PHARMACEUTICALS INC COM 6,780 New 299,356