BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 103
New Positions 8
Increased Positions 29
Decreased Positions 18
Positions with Activity 47
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,808

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.88%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.57%
Services
Technology
Transportation
Utilities

103 Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) Change (%) ▲ Shares Held
AEGERION PHARMACEUTICALS INC COM -8,846 Sold Out 0
ASTERIAS BIOTHERAPEUTICS INC COM SER A -60 Sold Out 0
BIOTIME INC WT EXP 100118 -21 Sold Out 0
CLOVIS ONCOLOGY INC COM -38,551 Sold Out 0
GALECTIN THERAPEUTICS INC COM NEW -1,260 Sold Out 0
REGADO BIOSCIENCES INC COM -341 Sold Out 0
SALIX PHARMACEUTICALS INC COM 887 -12,873 (93.55) 8,621
MALLINCKRODT PUB LTD CO SHS 17,566 -21,463 (54.99) 201,856
BIODELIVERY SCIENCES INTL INC COM 3,001 -3,015 (50.11) 210,021
INFINITY PHARMACEUTICALS INC COM 4,434 -4,434 (50) 312,025
SYNERGY PHARMACEUTICALS DEL COM NEW 2,803 -2,261 (44.65) 973,245
BLUEBIRD BIO INC COM 6,197 -1,994 (24.34) 150,000
IRONWOOD PHARMACEUTICALS INC COM CL A 4,791 -1,384 (22.41) 346,160
ACORDA THERAPEUTICS INC COM 27,077 -5,488 (16.85) 753,391
AGIOS PHARMACEUTICALS INC COM 16,113 -2,845 (15.01) 169,893
ARROWHEAD RESH CORP COM NEW 7,262 -1,180 (13.98) 1,230,802
TG THERAPEUTICS INC COM 30,283 -1,634 (5.12) 2,050,313
BIOCRYST PHARMACEUTICALS COM 110,672 -1,830 (1.63) 10,713,686
ACADIA PHARMACEUTICALS COM 582,287 New 20,481,442
ACCELERON PHARMA INC COM 1,002 New 28,765


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