BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,361

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.05%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.54%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) ▲ Change (%) Shares Held
VANDA PHARMACEUTICALS INC COM 19,305 -30,023 (60.86) 1,750,230
ABBVIE INC COM 2,499,653 -24,770 (0.98) 36,049,228
HALOZYME THERAPEUTICS INC COM 51,258 -12,038 (19.02) 2,248,152
SYNERGY PHARMACEUTICALS DEL COM NEW -7,971 Sold Out 0
AMICUS THERAPEUTICS INC COM -7,606 Sold Out 0
QLT INC COM -5,990 Sold Out 0
MALLINCKRODT PUB LTD CO SHS -5,744 Sold Out 0
BIOCRYST PHARMACEUTICALS COM 157,802 -3,546 (2.2) 10,478,204
DYAX CORP COM 148,911 -3,371 (2.21) 6,021,485
TEKMIRA PHARMACEUTICALS CORP COM NEW 1,860 -3,127 (62.7) 180,582
CHIMERIX INC COM 5,928 -2,943 (33.18) 115,216
XENOPORT INC COM 47,318 -2,872 (5.72) 6,508,622
ISIS PHARMACEUTICALS INC COM 3,067 -2,102 (40.67) 57,140
APTOSE BIOSCIENCES INC COM NEW 149 -1,984 (93.03) 33,397
TESARO INC COM -1,892 Sold Out 0
ACHILLION PHARMACEUTICALS INC COM 1,774 -1,856 (51.13) 214,237
IRONWOOD PHARMACEUTICALS INC COM CL A 1,768 -1,850 (51.13) 169,163
XOMA CORP DEL COM 12,120 -1,825 (13.09) 14,708,613
BELLICUM PHARMACEUTICALS INC COM 79,537 -1,768 (2.17) 4,190,594
GERON CORP COM -1,643 Sold Out 0


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