BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,391

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.13%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.61%
Services
Technology
Transportation
Utilities

101 Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) ▲ Change (%) Shares Held
ARROWHEAD RESH CORP COM NEW 9,261 -29,828 (76.31) 732,062
MEDIVATION INC COM -29,568 Sold Out 0
INTERCEPT PHARMACEUTICALS INC COM 59,571 -24,740 (29.34) 256,375
BIOCRYST PHARMACEUTICALS COM 73,455 -10,429 (12.43) 5,867,031
GW PHARMACEUTICALS PLC ADS -7,967 Sold Out 0
HALOZYME THERAPEUTICS INC COM 55,500 -5,833 (9.51) 5,698,139
PUMA BIOTECHNOLOGY INC COM -5,543 Sold Out 0
BIODELIVERY SCIENCES INTL INC COM 5,368 -5,419 (50.24) 421,005
QUESTCOR PHARMACEUTICALS INC COM 64,576 -5,229 (7.49) 717,745
VANDA PHARMACEUTICALS INC COM 65,352 -5,079 (7.21) 4,445,696
ISIS PHARMACEUTICALS INC COM 2,984 -4,671 (61.02) 96,303
STEMLINE THERAPEUTICS INC COM 4,338 -4,309 (49.83) 338,671
INSMED INC COM PAR $.01 9,469 -4,141 (30.43) 554,050
IDERA PHARMACEUTICALS INC COM NEW 4,081 -3,943 (49.14) 1,613,076
BIOMARIN PHARMACEUTICAL INC COM 116,421 -3,590 (2.99) 1,883,230
RECEPTOS INC COM 990 -3,151 (76.1) 23,900
SYNERGY PHARMACEUTICALS DEL COM NEW 6,418 -3,103 (32.59) 1,758,271
OPHTHOTECH CORP COM 1,436 -2,588 (64.31) 36,776
PROTHENA CORP PLC SHS 3,995 -1,854 (31.69) 230,142
UNITED THERAPEUTICS CORP DEL COM -1,819 Sold Out 0


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