BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2013

Position Statistics

Total Positions 88
New Positions 14
Increased Positions 31
Decreased Positions 21
Positions with Activity 52
Sold Out Positions 4
Total Mkt Value (in $ millions) 4,894

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.25%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.87%
Services
Technology
Transportation
Utilities

88 Positions as of 12/31/2013

Company Class Value of Shares ($1,000s) Change in Value ($1,000s) ▲ Change (%) Shares Held
GILEAD SCIENCES INC COM 37,910 -47,016 (55.36) 556,108
PHARMACYCLICS INC COM 800,947 -26,731 (3.23) 8,719,218
AEGERION PHARMACEUTICALS INC COM 21,200 -13,580 (39.05) 500,000
ARIAD PHARMACEUTICALS INC COM -8,922 Sold Out 0
TARGACEPT INC COM -8,273 Sold Out 0
IDERA PHARMACEUTICALS INC COM NEW 8,437 -7,164 (45.92) 3,171,765
PUMA BIOTECHNOLOGY INC COM 1,807 -5,420 (75) 25,000
HALOZYME THERAPEUTICS INC COM 46,535 -5,325 (10.27) 6,297,026
UNITED THERAPEUTICS CORP DEL COM 1,922 -3,458 (64.28) 20,000
MEI PHARMA INC COM NEW -3,042 Sold Out 0
STEMLINE THERAPEUTICS INC COM 10,510 -1,952 (15.66) 675,042
INSMED INC COM PAR $.01 10,010 -1,878 (15.8) 796,378
PORTOLA PHARMACEUTICALS INC COM 5,014 -1,686 (25.17) 224,434
NOVAVAX INC COM 4,749 -1,587 (25.05) 1,286,913
GERON CORP COM 749 -1,111 (59.74) 402,629
PROTHENA CORP PLC SHS 8,847 -860 (8.86) 336,918
CHEMOCENTRYX INC COM 263 -788 (75) 50,000
ARROWHEAD RESH CORP COM NEW 35,288 -571 (1.59) 3,090,000
ENANTA PHARMACEUTICALS INC COM 3,642 -531 (12.72) 109,097
CUBIST PHARMACEUTICALS INC COM -316 Sold Out 0


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