BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,620

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.14%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.49%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
CYTRX CORP COM PAR $.001 5,425 -123 (2.22) 1,319,989
JUNO THERAPEUTICS INC COM 5,264 New 100,000
IGNYTA INC COM 5,128 New 571,000
AMARIN CORP PLC SPONS ADR NEW 5,095 5,095 New 2,205,710
CHIMERIX INC COM 4,822 -2,394 (33.18) 115,216
STEMLINE THERAPEUTICS INC COM 4,592 -71 (1.53) 333,497
FOUNDATION MEDICINE INC COM 4,445 -68 (1.5) 124,255
EPIZYME INC COM 4,410 579 15.11 232,481
AFFIMED N V COM 4,172 New 400,000
ASSEMBLY BIOSCIENCES INC COM 4,165 4,165 New 250,000
INFINITY PHARMACEUTICALS INC COM 3,953 -91 (2.24) 305,037
RECEPTOS INC COM 3,941 New 23,900
ZOGENIX INC COM 3,907 -88 (2.21) 2,298,466
ISIS PHARMACEUTICALS INC COM 3,847 -2,636 (40.67) 57,140
LIPOCINE INC NEW COM 3,449 -76 (2.17) 489,175
NEURODERM LTD ORD SHS 3,410 New 250,000
AERIE PHARMACEUTICALS INC COM 3,332 New 299,356
BELLEROPHON THERAPEUTICS INC COM 3,248 3,248 New 350,000
ZAFGEN INC COM 3,085 3,085 New 94,745
ENANTA PHARMACEUTICALS INC COM 3,081 New 75,357