BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 9,989

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.2%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.61%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
RECEPTOS INC COM 5,446 New 23,900
AERIE PHARMACEUTICALS INC COM 5,430 New 299,356
EPIZYME INC COM 5,187 681 15.11 232,481
SAGE THERAPEUTICS INC COM 5,127 New 75,000
AMARIN CORP PLC SPONS ADR NEW 4,985 4,985 New 2,205,710
JUNO THERAPEUTICS INC COM 4,892 New 100,000
NEURODERM LTD ORD SHS 4,748 New 250,000
SUNESIS PHARMACEUTICALS INC COM NEW 4,464 New 3,200,000
KARYOPHARM THERAPEUTICS INC COM 4,453 2,522 130.61 216,990
ENANTA PHARMACEUTICALS INC COM 3,817 New 75,357
ASSEMBLY BIOSCIENCES INC COM 3,750 3,750 New 250,000
ZAFGEN INC COM 3,597 3,597 New 94,745
CYTRX CORP COM PAR $.001 3,590 -82 (2.22) 1,319,989
STEMLINE THERAPEUTICS INC COM 3,578 -56 (1.53) 333,497
MARINUS PHARMACEUTICALS INC COM 3,298 -74 (2.19) 200,000
ISIS PHARMACEUTICALS INC COM 3,139 -2,151 (40.67) 57,140
INTRA CELLULAR THERAPIES INC COM 3,031 3,031 New 104,166
PROTEON THERAPEUTICS INC COM 2,988 New 172,917
INFINITY PHARMACEUTICALS INC COM 2,666 -61 (2.24) 305,037
AURINIA PHARMACEUTICALS INC COM 2,633 -60 (2.22) 711,499