BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,571

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.13%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.63%
Services
Technology
Transportation
Utilities

101 Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
CELSUS THERAPEUTICS PLC SPONSORED ADR NE 3,811 3,811 New 673,887
LIGAND PHARMACEUTICALS INC COM NEW 3,756 New 73,400
BIOTA PHARMACEUTIALS INC COM 3,620 -76 (2.05) 1,106,910
ZOGENIX INC COM 3,408 -581 (14.56) 2,350,400
GALECTIN THERAPEUTICS INC COM NEW 3,300 2,636 397.02 500,000
ACHILLION PHARMACEUTICALS INC COM 3,191 -121 (3.66) 438,337
ENANTA PHARMACEUTICALS INC COM 3,132 -1,089 (25.79) 80,957
ISIS PHARMACEUTICALS INC COM 3,070 -4,805 (61.02) 96,303
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 2,263 2,263 New 221,631
RETROPHIN INC COM 2,189 2,189 New 197,178
AMICUS THERAPEUTICS INC COM 2,158 -150 (6.48) 481,697
KARYOPHARM THERAPEUTICS INC COM 2,126 -80 (3.64) 59,095
MACROGENICS INC COM 2,038 -81 (3.84) 96,165
SYNTA PHARMACEUTICALS CORP COM 2,005 New 500,000
ORASURE TECHNOLOGIES INC COM 1,971 -74 (3.62) 234,664
MAST THERAPEUTICS INC COM 1,800 1,800 New 3,000,000
RIGEL PHARMACEUTICALS INC COM NEW 1,644 -61 (3.61) 481,972
OPHTHOTECH CORP COM 1,502 -2,706 (64.31) 36,776
CATALYST PHARM PARTNERS INC COM 1,311 1,311 New 569,853
AUXILIUM PHARMACEUTICALS INC COM 1,190 1,190 New 58,544