BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,211

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.07%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.22%
Services
Technology
Transportation
Utilities

101 Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
CELSUS THERAPEUTICS PLC SPONSORED ADR NE 4,037 4,037 New 673,887
AMBIT BIOSCIENCES CORP COM 3,927 New 747,954
ZOGENIX INC COM 3,855 -657 (14.56) 2,350,400
STEMLINE THERAPEUTICS INC COM 3,820 -3,794 (49.83) 338,671
LIGAND PHARMACEUTICALS INC COM NEW 3,767 New 73,400
BIOTA PHARMACEUTIALS INC COM 3,332 -70 (2.05) 1,106,910
ENANTA PHARMACEUTICALS INC COM 3,102 -1,078 (25.79) 80,957
ACHILLION PHARMACEUTICALS INC COM 2,989 -114 (3.66) 438,337
ISIS PHARMACEUTICALS INC COM 2,768 -4,332 (61.02) 96,303
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 2,491 2,491 New 221,631
RETROPHIN INC COM 2,108 2,108 New 197,178
SYNTA PHARMACEUTICALS CORP COM 2,070 New 500,000
KARYOPHARM THERAPEUTICS INC COM 2,059 -78 (3.64) 59,095
ORASURE TECHNOLOGIES INC COM 1,920 -72 (3.62) 234,664
AMICUS THERAPEUTICS INC COM 1,826 -127 (6.48) 481,697
MACROGENICS INC COM 1,813 -72 (3.84) 96,165
MAST THERAPEUTICS INC COM 1,800 1,800 New 3,000,000
OPHTHOTECH CORP COM 1,519 -2,737 (64.31) 36,776
RIGEL PHARMACEUTICALS INC COM NEW 1,489 -56 (3.61) 481,972
CATALYST PHARM PARTNERS INC COM 1,242 1,242 New 569,853


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