BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 9,989

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.2%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.61%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
AGIOS PHARMACEUTICALS INC COM 16,522 -1,481 (8.23) 149,954
REPROS THERAPEUTICS INC COM NEW 14,800 New 2,000,000
ALCOBRA LTD SHS 13,227 11,085 517.47 1,789,871
SANGAMO BIOSCIENCES INC COM 12,852 4,110 47.02 1,404,544
THRESHOLD PHARMACEUTICAL INC COM NEW 12,638 3,326 35.72 2,925,519
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 12,525 -293 (2.28) 412,008
MACROGENICS INC COM 11,470 -257 (2.2) 305,043
LION BIOTECHNOLOGIES INC COM 11,342 11,342 New 1,325,000
XOMA CORP DEL COM 10,752 -1,619 (13.09) 14,708,613
OSIRIS THERAPEUTICS INC NEW COM 10,648 -243 (2.24) 499,193
OMEROS CORP COM 10,263 -172 (1.64) 637,446
CONCERT PHARMACEUTICALS INC COM 8,128 -156 (1.88) 495,908
ARROWHEAD RESH CORP COM NEW 7,973 367 4.83 1,290,187
LIGAND PHARMACEUTICALS INC COM NEW 7,945 -2 (0.02) 73,386
IGNYTA INC COM 7,914 New 571,000
AFFIMED N V COM 6,564 New 400,000
PROQR THRAPEUTICS N V SHS EURO 6,416 New 400,000
CHIMERIX INC COM 6,192 -3,074 (33.18) 115,216
LIPOCINE INC NEW COM 6,046 -134 (2.17) 489,175
ZOGENIX INC COM NEW 5,548 -125 (2.21) 287,308


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