BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 28
Decreased Positions 15
Positions with Activity 43
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,198

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.09%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.64%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
OSIRIS THERAPEUTICS INC NEW COM 7,358 2,148 41.24 510,606
BLUEBIRD BIO INC COM 7,357 New 198,260
EPIZYME INC COM 7,296 New 214,012
INFINITY PHARMACEUTICALS INC COM 6,721 New 624,050
SYNERGY PHARMACEUTICALS DEL COM NEW 6,506 New 1,758,271
MACROGENICS INC COM 6,484 4,485 224.33 311,891
DISCOVERY LABORATORIES INC NEW COM NEW 6,391 New 3,652,117
BIODELIVERY SCIENCES INTL INC COM 5,898 New 421,005
IRONWOOD PHARMACEUTICALS INC COM CL A 5,885 New 446,160
ARRAY BIOPHARMA INC COM 5,635 New 1,433,797
NOVAVAX INC COM 5,627 New 1,223,362
ULTRAGENYX PHARMACEUTICAL INC COM 5,588 New 100,000
XENCOR INC COM 5,538 New 542,363
AERIE PHARMACEUTICALS INC COM 5,320 New 299,356
CATALYST PHARM PARTNERS INC COM 5,046 3,753 290.11 2,223,053
AMBIT BIOSCIENCES CORP COM 4,465 New 747,954
CYTRX CORP COM PAR $.001 4,374 New 1,350,000
ACHILLION PHARMACEUTICALS INC COM 4,326 New 438,337
IGNYTA INC COM 4,311 New 571,000
LIPOCINE INC NEW COM 4,295 4,295 New 500,000