BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,513

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.08%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.67%
Services
Technology
Transportation
Utilities

101 Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SYNERGY PHARMACEUTICALS DEL COM NEW 6,594 -3,188 (32.59) 1,758,271
SANGAMO BIOSCIENCES INC COM 6,498 1,224 23.20 522,764
NEUROCRINE BIOSCIENCES INC COM 6,136 6,136 New 447,874
ARRAY BIOPHARMA INC COM 5,893 -272 (4.41) 1,433,797
INFINITY PHARMACEUTICALS INC COM 5,829 -179 (2.99) 624,050
DISCOVERY LABORATORIES INC NEW COM NEW 5,807 -106 (1.79) 3,652,117
AERIE PHARMACEUTICALS INC COM 5,778 -12 (0.22) 299,356
NOVAVAX INC COM 5,505 -286 (4.94) 1,223,362
BIODELIVERY SCIENCES INTL INC COM 5,494 -5,546 (50.24) 421,005
OSIRIS THERAPEUTICS INC NEW COM 5,401 -205 (3.66) 361,530
TEKMIRA PHARMACEUTICALS CORP COM NEW 5,369 -176 (3.17) 484,156
XENCOR INC COM 5,196 -73 (1.39) 542,363
IGNYTA INC COM 4,682 4,682 New 571,000
PORTOLA PHARMACEUTICALS INC COM 4,676 -1,072 (18.64) 182,591
CYTRX CORP COM PAR $.001 4,617 4,617 New 1,350,000
STEMLINE THERAPEUTICS INC COM 4,335 -4,306 (49.83) 338,671
IDERA PHARMACEUTICALS INC COM NEW 4,259 -4,115 (49.14) 1,613,076
ULTRAGENYX PHARMACEUTICAL INC COM 4,152 4,152 New 100,000
PROTHENA CORP PLC SHS 4,094 -1,900 (31.69) 230,142
AMBIT BIOSCIENCES CORP COM 4,069 New 747,954