BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,595

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.13%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.51%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
XENCOR INC COM 15,479 4,982 47.47 872,072
REPROS THERAPEUTICS INC COM NEW 14,520 New 2,000,000
LION BIOTECHNOLOGIES INC COM 13,899 13,899 New 1,325,000
ALCOBRA LTD SHS 13,317 11,160 517.47 1,789,871
ULTRAGENYX PHARMACEUTICAL INC COM 13,112 -97 (0.74) 148,894
OMEROS CORP COM 12,749 -213 (1.64) 637,446
THRESHOLD PHARMACEUTICAL INC COM NEW 11,293 2,972 35.72 2,925,519
MACROGENICS INC COM 9,752 -219 (2.2) 305,043
OSIRIS THERAPEUTICS INC NEW COM 9,325 -213 (2.24) 499,193
IMMUNOGEN INC COM 9,015 9,015 New 999,496
AQUINOX PHARMACEUTICALS INC COM 8,639 -165 (1.87) 1,187,666
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 8,302 -194 (2.28) 412,008
ARROWHEAD RESH CORP COM NEW 8,064 371 4.83 1,290,187
CONCERT PHARMACEUTICALS INC COM 7,820 -150 (1.88) 495,908
SUNESIS PHARMACEUTICALS INC COM NEW 7,456 New 3,200,000
PROQR THRAPEUTICS N V SHS EURO 7,452 New 400,000
LIGAND PHARMACEUTICALS INC COM NEW 6,469 -1 (0.02) 73,386
KARYOPHARM THERAPEUTICS INC COM 5,941 3,365 130.61 216,990
TRANSITION THERAPEUTICS INC COM NEW 5,900 5,900 New 769,230
SAGE THERAPEUTICS INC COM 5,485 New 75,000


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