BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 27
Decreased Positions 15
Positions with Activity 42
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,103

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.06%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.4%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BIODELIVERY SCIENCES INTL INC COM 6,896 New 421,005
OSIRIS THERAPEUTICS INC NEW COM 6,786 1,981 41.24 510,606
AERIE PHARMACEUTICALS INC COM 6,780 New 299,356
EPIZYME INC COM 6,395 New 214,012
QLT INC COM 6,143 New 1,535,863
MACROGENICS INC COM 6,141 4,248 224.33 311,891
NOVAVAX INC COM 6,105 New 1,223,362
CATALYST PHARM PARTNERS INC COM 5,958 4,431 290.11 2,223,053
IRONWOOD PHARMACEUTICALS INC COM CL A 5,934 New 446,160
SANGAMO BIOSCIENCES INC COM 5,881 New 522,764
XENCOR INC COM 5,695 New 542,363
CONCERT PHARMACEUTICALS INC COM 5,487 5,487 New 398,800
THRESHOLD PHARMACEUTICAL INC COM NEW 5,443 New 1,826,358
ARRAY BIOPHARMA INC COM 5,018 New 1,433,797
ULTRAGENYX PHARMACEUTICAL INC COM 4,973 New 100,000
ACHILLION PHARMACEUTICALS INC COM 4,918 New 438,337
SYNERGY PHARMACEUTICALS DEL COM NEW 4,888 New 1,758,271
STEMLINE THERAPEUTICS INC COM 4,426 New 338,671
INSMED INC COM PAR $.01 4,357 -3,583 (45.12) 304,050
ISIS PHARMACEUTICALS INC COM 4,080 New 96,303


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