BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 103
New Positions 8
Increased Positions 29
Decreased Positions 18
Positions with Activity 47
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,642

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.89%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.51%
Services
Technology
Transportation
Utilities

103 Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ULTRAGENYX PHARMACEUTICAL INC COM 6,675 2,225 50 150,000
THRESHOLD PHARMACEUTICAL INC COM NEW 6,345 975 18.17 2,158,141
BLUEBIRD BIO INC COM 6,278 -2,020 (24.34) 150,000
QLT INC COM 6,128 New 1,535,863
NOVAVAX INC COM 5,921 New 1,223,362
XENCOR INC COM 5,847 New 542,363
CONCERT PHARMACEUTICALS INC COM 5,784 675 13.21 451,496
DISCOVERY LABORATORIES INC NEW COM NEW 5,734 New 3,652,117
ACHILLION PHARMACEUTICALS INC COM 5,659 New 438,337
FOAMIX PHARMACEUTICALS LTD SHS 5,455 5,455 New 1,021,600
PROQR THRAPEUTICS N V SHS EURO 5,188 5,188 New 400,000
ARRAY BIOPHARMA INC COM 5,061 New 1,433,797
ISIS PHARMACEUTICALS INC COM 4,821 New 96,303
EPIZYME INC COM 4,820 New 214,012
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 4,710 2,234 90.24 421,631
STEMLINE THERAPEUTICS INC COM 4,694 New 338,671
IRONWOOD PHARMACEUTICALS INC COM CL A 4,573 -1,321 (22.41) 346,160
CELLADON CORP COM 4,406 4,406 New 375,000
INFINITY PHARMACEUTICALS INC COM 4,240 -4,240 (50) 312,025
IDERA PHARMACEUTICALS INC COM NEW 4,129 16 .38 1,619,258